Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 19,901–19,925 of 27,380 studies, newest first · page 797 of 1096.
September 2011 25
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2011-09-28
From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment
36/100 ✓ Peer-reviewed Clinical safety Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Key finding: Reduced NMDAR activity on inhibitory neurons leads to disinhibition of glutamate neurons increasing synaptic activity of glutamate, especially in the prefrontal cortex. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-28
Slower gait, slower information processing and smaller prefrontal area in older adults
60/100 ✓ Peer-reviewed Vascular contributions Age and ageing
Key finding: We conclude that smaller PFAv may contribute to slower gait through slower information processing. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-28
Dysregulated phosphorylation of Ca(2+) /calmodulin-dependent protein kinase II-α in the hippocampus of subjects with mild cognitive impairment and Alzheimer's disease
36/100 ✓ Peer-reviewed Disease mechanisms Journal of neurochemistry
Key finding: Studies in cell culture and rodents have shown that oligomers increase intracellular calcium (Ca(2+)), impairing synaptic plasticity. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-28
TREM‐2, triggering receptor expressed on myeloid cell‐2, negatively regulates TLR responses in dendritic cells
46/100 ✓ Peer-reviewed TREM2 and immune genetics European Journal of Immunology
DCs play a key role in defense against infections and also in preventing inflammatory and autoimmune diseases.
Full summary, score breakdown and related studies → Original source
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2011-09-27
Visual symptoms in Parkinson's disease and Parkinson's disease dementia
36/100 ✓ Peer-reviewed Risk factors Movement disorders : official journal of the Movement Disorder Society
Key finding: Dementia subjects reported illusions (65%) and presence (62%) more frequently than PD or control subjects, but the frequency of passage hallucinations in PD and PD dementia groups was equivalent (48% versus 69%, respectively; P = 0.102). +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-09-26
Aging and mental health in the decade ahead: what psychologists need to know
36/100 ✓ Peer-reviewed End-of-life care The American psychologist
Key finding: To meet the needs of the aging population, psychologists need to increase awareness of competencies for geropsychology practice and knowledge regarding dementia diagnosis, screening, and services. +4 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-25
Cognitive and memory training in adults at risk of dementia: a systematic review
67/100 ✓ Peer-reviewed Mild cognitive impairment BMC geriatrics
Key finding: Previous conclusions of a lack of efficacy for cognitive training in MCI may have been influenced by not clearly defining the intervention.
Full summary, score breakdown and related studies → Original source
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2011-09-23
Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease
46/100 ✓ Peer-reviewed Mild cognitive impairment The American journal of pathology
Key finding: Stereologic evaluation of NB tissue immunostained for pS422 and TauC3 revealed an increase in neurons expressing these tau epitopes during disease progression. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-23
Long-term consequences: effects on normal development profile after concussion
43/100 ✓ Peer-reviewed Caregiving Physical medicine and rehabilitation clinics of North America
Key finding: Alzheimer-like dementia, Parkinsonism, and motor neuron disease are also associated with repetitive brain trauma.
Full summary, score breakdown and related studies → Original source
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2011-09-22
Gait assessment in mild cognitive impairment and Alzheimer's disease: the effect of dual-task challenges across the cognitive spectrum
36/100 ✓ Peer-reviewed Digital health tools Gait & posture
Key finding: Gait velocity and stride time variability were not significantly different between the three groups under the single-task condition. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-09-22
Dying well with dementia: qualitative examination of end-of-life care
36/100 ✓ Peer-reviewed End-of-life care The British journal of psychiatry : the journal of mental science
Key finding: The quality of end-of-life care exists on a continuum across care settings.
Full summary, score breakdown and related studies → Original source
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2011-09-21
Stages of granulovacuolar degeneration: their relation to Alzheimer's disease and chronic stress response
40/100 ✓ Peer-reviewed Disease mechanisms Acta neuropathologica
Key finding: Our results showed five stages of GVD based on its distribution pattern: GVD began in the hippocampal subfields CA1, CA2, and the subiculum. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-09-21
Nurses will sign up to improve care in RCN dementia campaign
24/100 ✓ Peer-reviewed Health systems and care delivery Nursing Standard
Key finding: A five-point action plan designed to drive up the quality of hospital care for people with dementia is to be issued by the RCN this week.
Full summary, score breakdown and related studies → Original source
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2011-09-21
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
63/100 ✓ Peer-reviewed Lewy body dementia Neuron
Key finding: We have previously shown that a founder haplotype, covering the MOBKL2b, IFNK, and C9ORF72 genes, is present in the majority of cases linked to this region. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-09-21
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
62/100 ✓ Peer-reviewed Lewy body dementia Neuron
Key finding: Here, we report an expansion of a noncoding GGGGCC hexanucleotide repeat in the gene C9ORF72 that is strongly associated with disease in a large FTD/ALS kindred, previously reported to be conclusively linked to chromosome 9p. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-09-20
Functions of the APP gene family in the nervous system: insights from mouse models
41/100 ✓ Peer-reviewed Risk genes beyond APOE Experimental brain research
Key finding: During the past years, intense research efforts have been directed at elucidating the physiological function(s) of APP and the question of whether a perturbation of these functions contributes to AD pathogenesis. +2 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-20
Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial
66/100 ✓ Peer-reviewed Prevention and risk The British journal of nutrition
Key finding: Compared with the LA group, GDS scores improved in the EPA (P=0·04) and DHA (P=0·01) groups and verbal fluency (Initial Letter Fluency) in the DHA group (P=0·04). +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-09-17
A multidisciplinary intervention program improved the outcome after hip fracture for people with dementia--subgroup analyses of a randomized controlled trial
64/100 ✓ Peer-reviewed Clinical safety Archives of gerontology and geriatrics
Key finding: This study demonstrates that patients with dementia who suffer a hip fracture can benefit from multidisciplinary geriatric assessment and rehabilitation and should not be excluded from rehabilitation programs.
Full summary, score breakdown and related studies → Original source
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2011-09-17
Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease
47/100 ✓ Peer-reviewed Risk genes beyond APOE Free radical biology & medicine
Key finding: In addition, a growing number of flavonoids have been shown to inhibit the development of Alzheimer disease (AD)-like pathology and to reverse deficits in cognition in rodent models, suggestive of potential therapeutic utility in dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-16
BEaST: brain extraction based on nonlocal segmentation technique
36/100 ✓ Peer-reviewed Long-term cohort studies NeuroImage
Key finding: Robustness of BEaST is demonstrated on all baseline ADNI data, resulting in a very low failure rate. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-09-15
Improving decision-making for feeding options in advanced dementia: a randomized, controlled trial
69/100 ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society
Key finding: A decision aid about feeding options in advanced dementia reduced decisional conflict for surrogates and increased their knowledge and communication about feeding options with providers.
Full summary, score breakdown and related studies → Original source
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2011-09-15
Cost of disorders of the brain in Europe 2010
72/100 ✓ Peer-reviewed Caregiving European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Key finding: The total cost of disorders of the brain was estimated at €798 billion in 2010. +3 more findings
Full summary, score breakdown and related studies → Original source
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2011-09-15
Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers
45/100 ✓ Peer-reviewed Brain scans and imaging Lab on a chip
Key finding: The activation of striatal differentiation by cortical axons, and the synchronization of neural activity were demonstrated.
Full summary, score breakdown and related studies → Original source
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2011-09-14
Addressing the ethical, policy, and social challenges of preclinical Alzheimer disease
40/100 ✓ Peer-reviewed Clinical safety Neurology
Key finding: Research suggests that Alzheimer disease (AD) pathophysiology begins prior to the clinical expression of the disease and that biomarker measures may provide direct evidence of this process. +1 more finding
Full summary, score breakdown and related studies → Original source
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2011-09-14
Amygdala atrophy is prominent in early Alzheimer's disease and relates to symptom severity
55/100 ✓ Peer-reviewed Cognitive tests and assessment Psychiatry research
Key finding: In this study, we used magnetic resonance imaging (MRI) to compare the level of amygdala atrophy to that of the hippocampus in very mild and mild AD subjects in two large samples (Sample 1 n=90; Sample 2 n=174). +3 more findings
Full summary, score breakdown and related studies → Original source
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