alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 11,151–11,175 of 27,380 studies, newest first · page 447 of 1096.

September 2020 25

  1. 2020-09-29

    Measurement of CSF core Alzheimer disease biomarkers for routine clinical diagnosis: do fresh vs frozen samples differ?

    ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy

    Key finding: Cerebrospinal fluid (CSF) amyloid-beta (Aβ) 42/40 ratio, threonine-181-phosphorylated-tau (p-tau), and total-tau (t-tau) represent core biomarkers of Alzheimer disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2020-09-29

    Remote Blood Biomarkers of Longitudinal Cognitive Outcomes in a Population Study

    ✓ Peer-reviewed Biomarkers Annals of neurology

    Key finding: Higher concentrations of serum biomarkers were associated with the development of clinical AD; especially, the time-specific associations were notable: t-tau 8 to 16 years, and Nf-L and GFAP 4 to 8 years prior to clinical AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2020-09-28

    Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

    ✓ Peer-reviewed Treatments Nature structural & molecular biology

    Key finding: Our results reveal that, uniquely among these four antibodies, aducanumab dramatically reduces the flux of Aβ oligomers.

    Full summary, score breakdown and related studies → Original source

  4. 2020-09-28

    An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease

    ✓ Peer-reviewed Genetics Nature genetics

    Key finding: RNA sequencing analysis revealed upregulation of transcription- and chromatin-related genes, including the histone acetyltransferases for H3K27ac and H3K9ac. +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2020-09-28

    Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease

    ✓ Peer-reviewed Genetics Proceedings of the National Academy of Sciences of the United States of America

    Key finding: Differential analysis shows that the cell type-specific transcriptomic changes in AD are associated with the disruption of biological processes including angiogenesis, immune activation, synaptic signaling, and myelination. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2020-09-28

    Combination of plasma amyloid beta (1-42/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology

    ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

    Key finding: Abeta (1-42/1-40) and GFAP independently associated with amyloid PET status (p = 0.009 and p < 0.001 respectively), and GFAP and NfL independently associated with syndrome diagnosis (p = 0.001 and p = 0.048 respectively). +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2020-09-28

    Enhancing cognitive training effects in Alzheimer's disease: rTMS as an add-on treatment

    ✓ Peer-reviewed Prevention trials Brain stimulation

    Key finding: The results showed that the improvement in the trained associative memory induced with rTMS was superior to that obtained with CT alone. +1 more finding

    Full summary, score breakdown and related studies → Original source

  8. 2020-09-28

    Association of midlife vascular risk and AD biomarkers with subsequent cognitive decline

    ✓ Peer-reviewed Tau biomarkers Neurology

    Key finding: At baseline, participants (n = 168) were cognitively normal and primarily middle-aged (mean 56.4 years, SD 10.9 years) and had both vascular risk factor status and proximal CSF biomarkers available. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2020-09-28

    Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

    ✓ Peer-reviewed TREM2 and immune genetics Circulation research

    Key finding: Atherosclerotic lesions are known for their cellular heterogeneity, yet the molecular complexity within the cells of human plaques has not been fully assessed. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2020-09-28

    β-Amyloid and tau biomarkers and clinical phenotype in dementia with Lewy bodies

    ✓ Peer-reviewed Genetics Neurology

    Key finding: Alzheimer disease pathologic changes are common in DLB and are associated with the clinical phenotype. β-Amyloid is associated with cognitive impairment, and tau pathology is associated with lower frequency of clinical features of DLB. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2020-09-25

    Social factors that predict cognitive decline in older African American adults

    ✓ Peer-reviewed Risk factors International journal of geriatric psychiatry

    Key finding: Social activity was associated with global cognition, perceptual speed, perceptual orientation, and episodic memory over time. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2020-09-25

    Selective Aberrant Functional-Structural Coupling of Multiscale Brain Networks in Subcortical Vascular Mild Cognitive Impairment

    ✓ Peer-reviewed Brain scans and imaging Neuroscience bulletin

    Key finding: We found no significant intergroup differences in the functional-structural coupling within the whole brain; however, there was significantly increased functional-structural coupling within the dorsal attention module and decreased functional-structural coupling within the ventral attention module in the svMCI group. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2020-09-25

    Exploring the genetic relationship between hearing impairment and Alzheimer's disease

    ✓ Peer-reviewed Genetics Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: We found a significant genetic overlap between hearing impairment and AD and a polygenic risk score for AD was able to significantly predict hearing loss in an independent cohort. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2020-09-25

    Plasma NT1 Tau is a Specific and Early Marker of Alzheimer's Disease

    ✓ Peer-reviewed Biomarkers Annals of neurology

    Key finding: Plasma NT1 tau was specifically elevated in AD, but not in non-AD dementia compared with controls, whereas NfL was increased in both AD and non-AD dementias. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2020-09-24

    Amyloid PET imaging in clinical practice

    ✓ Peer-reviewed Brain scans and imaging Practical neurology

    Key finding: There is increasing evidence to support its clinical utility, with major studies showing that amyloid PET imaging improves diagnostic accuracy, increases diagnostic certainty and results in therapeutic changes.

    Full summary, score breakdown and related studies → Original source

  16. 2020-09-24

    Plasma amyloid, tau, and neurodegeneration biomarker profiles predict Alzheimer's disease pathology and clinical progression in older adults without dementia

    ✓ Peer-reviewed Long-term cohort studies Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: Plasma markers have been reported to be associated with brain amyloid burden, tau pathology, or neurodegeneration. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2020-09-24

    Evaluation of a novel immunoassay to detect p-tau Thr217 in the CSF to distinguish Alzheimer disease from other dementias

    ✓ Peer-reviewed Tau biomarkers Neurology

    Key finding: We developed and validated a novel Simoa immunoassay to detect p-tau T217 in CSF. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2020-09-24

    Telemedicine and the rural dementia population: A systematic review

    ✓ Peer-reviewed Digital health tools Maturitas

    Key finding: The testing conditions and the accessibility of telemedicine yield inconclusive results as to whether telemedicine can improve the management of dementia in geriatric individuals. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2020-09-24

    An Internet-Based Intervention Augmented With a Diet and Physical Activity Consultation to Decrease the Risk of Dementia in At-Risk Adults in a Primary Care Setting: Pragmatic Randomized Controlled Trial

    ✓ Peer-reviewed Treatments Journal of medical Internet research

    Key finding: Baseline assessments were conducted on 128 participants. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2020-09-23

    Change in Social Engagement among Incident Caregivers and Controls: Findings from the Caregiving Transitions Study

    ✓ Peer-reviewed Risk factors Journal of aging and health

    Key finding: Incident caregivers reported lower satisfaction with social activities and greater decline in social network size than controls. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2020-09-23

    Role of metformin in various pathologies: state-of-the-art microcapsules for improving its pharmacokinetics

    ✓ Peer-reviewed Drug development Therapeutic delivery

    Key finding: In the last century, metformin was discovered twice for its antiglycemic properties in addition to its antimalarial and anti-influenza effects. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2020-09-23

    The Impact of Amyloid-Beta Positivity with 18F-Florbetaben PET on Neuropsychological Aspects in Parkinson's Disease Dementia

    ✓ Peer-reviewed Brain scans and imaging Metabolites

    Key finding: The results of cognitive tests, neuropsychiatric symptoms, and motor symptoms were analyzed between the positive and negative 18F-florbetaben PET groups. +1 more finding

    Full summary, score breakdown and related studies → Original source

  23. 2020-09-23

    Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture

    ✓ Peer-reviewed Genetics Nature communications

    Key finding: Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer's disease (LOAD). +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2020-09-23

    Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study

    ✓ Peer-reviewed Vascular contributions Diabetes care

    Key finding: Older people with diabetes receiving metformin have slower cognitive decline and lower dementia risk. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2020-09-23

    Prevalence and clinical associations of tau in Lewy body dementias: A systematic review and meta-analysis

    ✓ Peer-reviewed Disease mechanisms Parkinsonism & related disorders

    Key finding: Tau is common in LBD and may reduce clinical diagnostic accuracy in people with DLB. +1 more finding

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →