Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 7,401–7,425 of 27,380 studies, newest first · page 297 of 1096.
September 2023 2
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2023-09-01
Vegetarian and vegan diets: benefits and drawbacks
60/100 ✓ Peer-reviewed Prevention and risk European heart journal
Key finding: Prospective studies suggest that consuming vegetarian diets is associated with a reduced risk of developing cardiovascular disease (CVD), diabetes, hypertension, dementia, and cancer.
Full summary, score breakdown and related studies → Original source
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2023-09-01
Association of Plasma Phosphorylated Tau With the Response to Neflamapimod Treatment in Patients With Dementia With Lewy Bodies
71/100 ✓ Peer-reviewed Treatments Neurology
Key finding: In a proportion of patients, dementia with Lewy bodies (DLB) is associated with Alzheimer disease (AD) copathology, which is linked to accelerated cognitive decline and more extensive cortical atrophy. +4 more findings
Full summary, score breakdown and related studies → Original source
August 2023 23
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2023-08-31
Crosstalk between NLRP3 inflammasome and calpain in Alzheimer's disease
41/100 ✓ Peer-reviewed Inflammation and the immune system The European journal of neuroscience
Key finding: Further, calpain hyperactivation is also associated with calcium homeostasis that acts as one of the triggers in the activation of NLRP3 inflammasome. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-08-31
Stroke Prevention
41/100 ✓ Peer-reviewed Prevention and risk Delaware journal of public health
Key finding: In addition to stroke prevention, these strategies help with overall brain health, which may also have an impact on neurological degenerative diseases such as Alzheimer's disease.
Full summary, score breakdown and related studies → Original source
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2023-08-31
Alzheimer's Disease: Causal Effect between Obesity and APOE Gene Polymorphisms
41/100 ✓ Peer-reviewed Genetics International journal of molecular sciences
Key finding: Bioinformatics analysis revealed Apolipoprotein E (APOE) as the key target of obesity-induced AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-31
Artificial intelligence for biomarker discovery in Alzheimer's disease and dementia
56/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Overcoming these challenges will involve collecting data from underrepresented populations, developing more powerful AI approaches, validating the use of noninvasive biomarkers, and adhering to reporting guidelines. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-31
A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases
77/100 ✓ Peer-reviewed Biomarkers Nature Aging
Key finding: Depending on whether lenient, moderate or stringent thresholds were used in step 1, the two-step workflow overall accuracy for detecting Aβ-PET status was 88.2%, 90.5% and 92.0%, respectively, while reducing the number of necessary CSF tests by 85.9%, 72.7% and 61.2%, respectively. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-08-30
GLP-1 receptor agonists effect on cognitive function in patients with and without type 2 diabetes
40/100 ✓ Peer-reviewed Drug development Diabetes & metabolism
Key finding: Glucagon-like peptide 1 (GLP-1) is a hormone of the incretin family, secreted in response to nutrient ingestion, and plays a role in metabolic homeostasis. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-08-30
Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer's disease mice
43/100 ✓ Peer-reviewed Treatments Molecular neurodegeneration
Key finding: Our study establishes a connection between Aβ antibodies engaged at CAA deposits, the activation of perivascular macrophages, and the upregulation of genes involved in vascular permeability. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-30
Evaluation of Neighborhood-Level Disadvantage and Cognition in Mexican American and Non-Hispanic White Adults 50 Years and Older in the US
60/100 ✓ Peer-reviewed Risk factors JAMA Network Open
Key finding: Among 1614 older adults (mean [SD] age, 66.3 [8.7] years; 980 women [60.7%]), 853 were Mexican American (mean [SD] age, 63.9 [7.9] years; 566 women [66.4%]), and 761 were non-Hispanic White (mean [SD] age, 69.1 [8.7] years; 414 women [54.4%]). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-29
Microbiota-gut-brain axis and ketogenic diet: how close are we to tackling epilepsy?
41/100 ✓ Peer-reviewed Disease mechanisms Microbiome research reports
Key finding: This axis has been suggested to play a role in several neurological disorders, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, and epilepsy, paving the way for microbiome-based intervention strategies for the mitigation and treatment of symptoms. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-29
Key variants via Alzheimer's Disease Sequencing Project whole genome sequence data
45/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Seventeen variants were significantly associated with AD within five genomic regions implicating the genes OARD1/NFYA/TREML1, JAZF1, FERMT2, and SLC24A4. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-29
Randomized Phase II Study of the Safety and Efficacy of Semorinemab in Participants With Mild-to-Moderate Alzheimer Disease: Lauriet
74/100 ✓ Peer-reviewed Treatments Neurology
Key finding: Based on the results of the prespecified coprimary endpoints, this study was negative. +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-28
α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies
48/100 ✓ Peer-reviewed Brain tissue and pathology NPJ Parkinson's disease
Key finding: Specific protein aggregates associated with neurodegenerative diseases are present in the retina and could be visualised in a non-invasive way. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-08-28
Highly functionalized diaminocyclopentanes: A new route to potent and selective inhibitors of human O-GlcNAcase
41/100 ✓ Peer-reviewed Drug development Bioorganic chemistry
Key finding: A new class of compounds inhibiting de-O-glycosylation of proteins has been identified. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-28
Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults
69/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Plasma p-tau217 may capture earlier Alzheimer's disease (AD)-related cognitive and brain atrophy hallmarks in females compared to males, possibly reflective of increased susceptibility to AD pathophysiology. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-08-25
Vascular cognitive impairment - Past, present, and future challenges
41/100 ✓ Peer-reviewed Vascular contributions Ageing research reviews
Key finding: However, little is known about the pathological processes underlying VCI and the temporal dynamics between risk factors and disease mechanisms (biochemical and structural brain changes). +4 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-24
Primary retinal tauopathy: A tauopathy with a distinct molecular pattern
61/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Retinal p-tau pathology showed a consistent pattern with four stages and a molecular composition distinct from that of cerebral tauopathies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-24
Obstructive sleep apnea and dementia: A role to play?
41/100 ✓ Peer-reviewed Risk factors Revue neurologique
Key finding: Among sleep disorders, obstructive sleep apnea (OSA) appears to be a potentially interesting comorbidity, as it is highly prevalent in the middle-aged and elderly population, often associated with some cognitive impairment, associated with an increased risk of developing cognitive decline and dementia including AD, and indeed treatable. +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-08-24
Racially fair pupillometry measurements for RGB smartphone cameras using the far red spectrum
52/100 ✓ Peer-reviewed Cognitive tests and assessment Scientific reports
Key finding: Prior work have demonstrated the potential for pupillometry in screening or diagnosing a number of neurological disorders including Alzheimer's Disease, Schizophrenia, and Traumatic Brain Injury.
Full summary, score breakdown and related studies → Original source
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2023-08-24
Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer's disease
41/100 ✓ Peer-reviewed Biomarkers Scientific reports
Key finding: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of Aβ plaques and neurofibrillary tangles, resulting in synaptic loss and neurodegeneration. +2 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-22
HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent
45/100 ✓ Peer-reviewed Brain tissue and pathology Nature communications
Key finding: HtrA1 is a PDZ serine protease that degrades fibrillar tau, which is associated with Alzheimer disease (AD). +1 more finding
Full summary, score breakdown and related studies → Original source
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2023-08-22
Gastrointestinal Dysfunction in Neurological and Neurodegenerative Disorders
41/100 ✓ Peer-reviewed Disease mechanisms Seminars in neurology
Key finding: Because healthier cognitive phenotypes are observed in individuals with more distinct microbiomes, increased efforts are warranted to develop therapeutic strategies for those at increased risk of developing neurological disorders and patients diagnosed with those disorders.
Full summary, score breakdown and related studies → Original source
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2023-08-22
Evaluating the Clinical Significance of Diazepam Binding Inhibitor in Alzheimer's Disease: A Comparison with Inflammatory, Oxidative, and Neurodegenerative Biomarkers
39/100 ✓ Peer-reviewed Tau biomarkers Gerontology
Key finding: Alzheimer's disease (AD) is one of the pathologies that the scientific world is still desperate for. +3 more findings
Full summary, score breakdown and related studies → Original source
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2023-08-21
Elevated amyloid beta peptides and total tau in cerebrospinal fluid in individuals with Creatine transporter deficiency
42/100 ✓ Peer-reviewed Tau biomarkers Molecular genetics and metabolism reports
Key finding: Creatine transporter deficiency (CTD) is a rare X-linked disorder of creatine transport caused by pathogenic variants in SLC6A8 (Xq28). +3 more findings
Full summary, score breakdown and related studies → Original source
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