Newest studies

Nonpharmacological multicomponent intervention for mild cognitive impairment with a family-patient approach: protocol for the pilot clinical trial—INTERCOG study

43/100 ✓ Peer-reviewed Mild cognitive impairment PubMed Central

Key finding: Multicomponent and transdisciplinary interventions focused on the family member–patient dyad have the potential to optimize cognitive outcomes and quality of life.

• Clinical Trials
• Early Stage
• Caregiving

Full summary, score breakdown and related studies → Original source

Lewy Bodies Are Not Associated With Neuronal or Synaptic Loss in Dementia With Lewy Bodies

43/100 ✓ Peer-reviewed Lewy body dementia Neuropathology and Applied Neurobiology

Key finding: Across both regions, no evidence of reduced total neuronal density was observed, but a modest reduction in parvalbumin interneurons was observed in the cingulate gyrus, and there were only modest reductions in some synaptic markers in DLB. +3 more findings

• Other Dementias
• Brain Biology

Full summary, score breakdown and related studies → Original source

Dementia etiology classification using NULISA plasma biomarkers and machine learning

62/100 ✓ Peer-reviewed Digital health tools Alzheimer s & Dementia

Key finding: NULISA plasma biomarkers revealed disease-specific protein patterns. +4 more findings

• Biomarkers
• Digital Tools

Full summary, score breakdown and related studies → Original source

From Hearing Aid Uptake to Hearing Aid Effectiveness: Rethinking Dementia Risk Reduction in Adults With Hearing Loss

52/100 ✓ Peer-reviewed Prevention and risk Sensory Neuroscience

Key finding: Hearing aid use was associated with a modestly lower risk of probable dementia overall (Hazard Ratios, HR, 0.91), but the association was confined to participants reporting improvements in hearing (HR 0.86), with no apparent benefit among those reporting poor improvement in hearing (HR 0.98). +1 more finding

• Risk Factors
• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Lecanemab: Wirksamkeit beruht auf dem Fc-Fragment des Antikörpers

26/100 ✓ Peer-reviewed Treatments Fortschritte der Neurologie · Psychiatrie

Key finding: Lecanemab ist eine Anti-Amyloid-Antikörper-Therapie, die entwickelt wurde, um toxische Amyloid-Plaques zu beseitigen und das Fortschreiten der Alzheimer-Krankheit zu verlangsamen. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Evaluation of the relationships between inflammatory markers and processing speed in recent-onset and chronic schizophrenia: a polygenic risk score study

35/100 ✓ Peer-reviewed Genetics European Psychiatry

Key finding: Hierarchical linear regression was used to assess an incremental contribution of the set of inflammatory markers’ PRS to explaining VF variance compared to the null model. +4 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

Porphyromonas gingivalis disrupts hippocampal circadian clock via PI3K/AKT pathway, exacerbating Alzheimer‐like pathology

36/100 ✓ Peer-reviewed Biomarkers Alzheimer s & Dementia

Key finding: P. gingivalis-induced periodontitis dampened hippocampal Bmal1 rhythms, lowered p-AKT, activated glia, and elevated Aβ and interleukin 1β (IL-1β). +3 more findings

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Variability in Clinical Performance of the FDA-Cleared Lumipulse P-Tau217/β-Amyloid 1-42 Plasma Ratio

54/100 ✓ Peer-reviewed Biomarkers JAMA Neurology

Key finding: This cross-sectional study evaluates the performance of the US Food and Drug Administration–cleared phosphorylated tau 217 (p-tau217) to β-amyloid 42 ratio cut points used to detect amyloid pathology associated with Alzheimer disease.

• Biomarkers

Full summary, score breakdown and related studies → Original source

Meeting the mental health needs of people with the complex neurodevelopment condition, Prader-Willi syndrome: a major challenge for mental health services

30/100 ✓ Peer-reviewed Risk factors European Psychiatry

Key finding: The behavioural and mental health needs of people with PWS result from the interactions between biological vulnerabilities associated with having PWS and living in a changing and demanding environment. +3 more findings

• Risk Factors

Full summary, score breakdown and related studies → Original source

Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study

48/100 ✓ Peer-reviewed Tau biomarkers The Lancet. Neurology

Key finding: Individuals with autosomal dominant Alzheimer's disease (ADAD) arising from mutations in PSEN1, PSEN2, or APP exhibit variability in clinical presentation. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Imaging and plasma biomarkers for pathological accumulation in Down syndrome

59/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Brain : a journal of neurology

Key finding: These results suggest that all adults with Down syndrome should be screened for Alzheimer's disease pathology starting shortly before age 40 years and considered for clinical trials.

• Down Syndrome
• Biomarkers

Full summary, score breakdown and related studies → Original source

Cost utility and cost-effectiveness of the APPLE-Tree programme: Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce: economic evaluation embedded within a randomised controlled trial

61/100 ✓ Peer-reviewed Costs and economics Age and ageing

Key finding: APPLE-Tree has a high probability of being cost-effective for a 1-point NTB gain, a difference previously associated with a three-fold reduction in 5-year dementia risk. +2 more findings

• Clinical Trials
• Policy
• Risk Factors

Full summary, score breakdown and related studies → Original source

Efficacy of a language-concordant community health worker intervention to improve community-to-clinic linkage for dementia care: results of the randomized trial PLAN

60/100 ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: Longer follow-up and testing across diverse LEP communities are needed to assess diagnosis, treatment initiation, and caregiver trajectories.

• Clinical Trials
• Health Equity

Full summary, score breakdown and related studies → Original source

Diet Quality and Dementia Risk in Older Adults With Alzheimer Pathology

60/100 ✓ Peer-reviewed Prevention and risk JAMA Network Open

Key finding: Over a mean follow-up of 8.4 years (range, Conclusions and relevance This cohort study of older adults found that adherence to a dietary pattern with lower inflammatory potential was associated with lower dementia risk among individuals with AD pathology and broader neurobiological risk. +2 more findings

• Risk Factors
• Lifestyle
• Biomarkers

Full summary, score breakdown and related studies → Original source

Brain Imaging Biomarkers and Cognitive Outcomes in a Multidomain Lifestyle Intervention: The POINTER Imaging Ancillary Study

65/100 ✓ Peer-reviewed Prevention and risk JAMA Neurology

Key finding: This study found that a high-intensity multidomain lifestyle intervention did not affect brain biomarker trajectories and was not associated with Aβ pathology, but older adults with specific at-risk brain characteristics, including lower baseline HC volume, showed a greater cognitive benefit of the structured intervention. +3 more findings

• Brain Scans
• Clinical Trials
• Biomarkers

Full summary, score breakdown and related studies → Original source

Benefits and Harms of Dementia Screening for Family Members of Older Adults: A Randomized Clinical Trial

60/100 ✓ Peer-reviewed Getting a diagnosis JAMA Internal Medicine

Key finding: This randomized clinical trial found that ADRD screening in PC was not associated with improvement in family member health-related quality of life, caregiver preparedness, or caregiving self-efficacy. +4 more findings

• Clinical Trials
• Diagnosis
• Caregiving

Full summary, score breakdown and related studies → Original source

Neighborhood disadvantage and cognitive function in older adults: The moderating role of young adult general cognitive ability

36/100 ✓ Peer-reviewed Risk factors Health & Place

Key finding: Neighborhood disadvantage in later life is associated with poorer cognition and increased vulnerability to dementia. +1 more finding

• Health Equity

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Institutional Special Needs Plans and End-of-Life Outcomes for Nursing Home Residents With Dementia

50/100 ✓ Peer-reviewed Health systems and care delivery JAMA Health Forum

Key finding: The study cohort included 1 415 265 long-stay nursing home residents with dementia who died between 2013 and 2022. +4 more findings

• Care Services
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

Association of plasma glial fibrillary acidic protein and neurofilament light chain with retinal cell layer thickness: A cross-sectional study of ophthalmic surgical patients

59/100 ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease : JAD

Key finding: BackgroundRetinal thickness has been associated with neurocognitive conditions such as Alzheimer's disease (AD).ObjectiveRetinal cell layer thickness was evaluated for associations with neurodegenerative protein biomarkers glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) in plasma, vitreous humor, and aqueous humor. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Combating cognitive decline in a rat model of Alzheimer’s disease: The role of high-intensity interval training and cannabidiol administration in modulating microRNA-124, BACE1, and nestin

30/100 ✓ Peer-reviewed Risk genes beyond APOE Current Journal of Neurology

Key finding: HIIT alone and in combination with CBD treatment significantly improved cognitive impairment induced by AD. +3 more findings

Full summary, score breakdown and related studies → Original source

Dementia diagnostic deserts: workforce and geographic inequities in the diagnostic pathway for cognitive impairment

43/100 ✓ Peer-reviewed Health systems and care delivery Health affairs scholar

Key finding: Nurse practitioners and physician assistants are frontline providers in these underserved regions but face significant training gaps and practice-level infrastructure barriers.

• Health Equity
• Diagnosis

Full summary, score breakdown and related studies → Original source

Convergence of neuroinflammation across major neurotropic viral exposomes in AD and ADRD

39/100 ✓ Peer-reviewed Inflammation and the immune system Journal of Neuroinflammation

Key finding: Across diverse viral infections, strong convergence was observed in innate immune activation pathways, including microglial priming and NLRP3 inflammasome signaling, accompanied by chronic production of proinflammatory cytokines (IL-1β, TNF-α, IFN-γ). +4 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Assessing the de novo paradigm in sporadic early-onset Alzheimer disease trios

41/100 ✓ Peer-reviewed Genetics Molecular Psychiatry

Key finding: No significant burden of rare coding variants in exome/genome data from 5643 EOAD cases and 16097 controls was identified using nested windows centered on each DNM position, at the transcript level. +1 more finding

• Genetics

Full summary, score breakdown and related studies → Original source

Associations between Alzheimer's disease blood biomarkers and neighborhood disadvantage: A HABS-HD community cohort study

32/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease

Key finding: BackgroundNeighborhood disadvantage has been associated with reduced cognitive reserve, increased risk for cognitive impairment, and greater Alzheimer's disease (AD) neuropathology, with particularly pronounced effects among Black and Hispanic/Latino older adults. +3 more findings

• Biomarkers
• Health Equity

Full summary, score breakdown and related studies → Original source

Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals

33/100 ✓ Peer-reviewed Risk factors Carolina Digital Repository (University of North Carolina at Chapel Hill)

Key finding: Among 15,346 White, 829 Latino, 637 Black/African American, and 321 Asian individuals, 51% were female, mean age was 75.7 years, 535 (3.8%) resided in ADI 91 to 100 decile, and 61.6% were amyloid PET positive. +2 more findings

• Health Equity
• Brain Scans

Full summary, score breakdown and related studies → Original source