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45/100

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Long-term cohort studies

Topic: Risk, prevention and care in population studies

Objective To investigate optimal cutoff scores and the effects of normative adjustments on the performance of the Montreal Cognitive Assessment (MoCA) as a screening instrument for Mild Cognitive Impairment (MCI) and dementia due to Alzheimer's disease (AD-dementia). Methods 499 adults 48 to 91 years-old enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI) and were administered the MoCA during baseline. Participants were classified as either cognitively normal (CN), MCI, or AD-dementia by clinical assessment.

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APA 7th

Pugh, E. A., Kemp, E. C., van Dyck, C. H., Mecca, A. P., Sharp, E. S., & Alzheimer's Disease Neuroimaging Initiative. (2018). Effects of Normative Adjustments to the Montreal Cognitive Assessment. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. https://doi.org/10.1016/j.jagp.2018.09.009

Vancouver

Pugh EA, Kemp EC, van Dyck CH, Mecca AP, Sharp ES, Alzheimer's Disease Neuroimaging Initiative. Effects of Normative Adjustments to the Montreal Cognitive Assessment. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2018. doi:10.1016/j.jagp.2018.09.009. PMID: 30314940.

BibTeX

@article{pugh2018-30314940,
  author  = {Pugh, E. A. and Kemp, E. C. and van Dyck, C. H. and Mecca, A. P. and Sharp, E. S. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Effects of Normative Adjustments to the Montreal Cognitive Assessment}},
  journal = {The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year    = {2018},
  doi     = {10.1016/j.jagp.2018.09.009},
  pmid    = {30314940},
  url     = {https://doi.org/10.1016/j.jagp.2018.09.009}
}

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Key findings

Methods 499 adults 48 to 91 years-old enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI) and were administered the MoCA during baseline.
Participants were classified as either cognitively normal (CN), MCI, or AD-dementia by clinical assessment.
Receiver operating characteristic (ROC) analyses were performed using raw MoCA scores, education-adjusted MoCA scores, and a regression-based adjustment derived from the National Alzheimer's Coordinating Center data (NACC).
Test performance characteristics were calculated for various cutoffs after each normative correction method.

Why it matters

This study tested whether adjusting Montreal Cognitive Assessment scores for education and other norms improves screening for mild cognitive impairment and Alzheimer's dementia in 499 adults. It addresses how memory screening is scored, not how Alzheimer's is treated, cured, or prevented.

Study details

Participants499
Evidence strengthLow

How this study scored 45/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry)
Journal's citation record	2 / 4	American Journal of Geriatric Psychiatry: journal h-index 178 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2018 — within 10 year(s) of the newest study here
Sample size	2 / 4	499 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	4 / 7	Cited 60 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	6.0 citations a year over 10 year(s) since 2018
Impact for its field and year	2 / 6	Cited 2.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 3 other studies in this library
Still being cited	2 / 4	Cited 33 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Emily Schoenhofen Sharp: h-index 10 (OpenAlex, whole career)
Institution's track record	2 / 3	Yale University: institution h-index 1,927 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 30314940)
Free to read	0 / 2	Behind a paywall — scores zero
Total	45 / 100	—

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