Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,901–12,925 of 27,380 studies, newest first · page 517 of 1096.
April 2019 25
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2019-04-24
Insulin Signaling Impairment in the Brain as a Risk Factor in Alzheimer's Disease
41/100 ✓ Peer-reviewed Drug development Frontiers in aging neuroscience
Key finding: The first clinical trials show promising results and are a proof of concept that utilizing such treatments is valid.
Full summary, score breakdown and related studies → Original source
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2019-04-24
Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies
41/100 ✓ Peer-reviewed Biomarkers Frontiers in nutrition
Key finding: Interestingly, several observations indicate that the calibrated assumption of correct doses of vitamins such as folic acid, vitamin B6, vitamin B12, and betaine may control HHCys-related conditions.
Full summary, score breakdown and related studies → Original source
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2019-04-24
Cognitive outcomes following coronary artery bypass grafting: A systematic review and meta-analysis of 91,829 patients
81/100 ✓ Peer-reviewed Clinical safety International journal of cardiology
Key finding: The results of this meta-analysis demonstrate that cognitive impairment and delirium are major issues in CABG patients which require specific attention. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-04-24
Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review
57/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in neurology
Key finding: The results should, however, be interpreted cautiously due to the limited number of studies.
Full summary, score breakdown and related studies → Original source
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2019-04-24
Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease
53/100 ✓ Peer-reviewed Biomarkers Frontiers in neurology
Key finding: The failure to find an association between PET amyloid deposition and cognitive impairment in a moderately large sample, particularly given that it was enriched with PD-MCI patients at risk of dementia, suggests that amyloid pathology is not the primary driver of cognitive impairment and dementia in most patients with PD.
Full summary, score breakdown and related studies → Original source
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2019-04-23
Smartphone-Based Interventions to Foster Simple Activity and Personal Satisfaction in People With Advanced Alzheimer's Disease
39/100 ✓ Peer-reviewed Cognitive tests and assessment American journal of Alzheimer's disease and other dementias
Key finding: All participants had significant increases in independent response frequencies, level of personal satisfaction, and heart rates during program sessions as opposed to baseline or control sessions. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-04-23
Obesity, Brain Volume, and White Matter Microstructure at MRI: A Cross-sectional UK Biobank Study
55/100 ✓ Peer-reviewed Long-term cohort studies Radiology
Key finding: Obesity has been associated with increased risk of accelerated cognitive decline and dementia, which suggests underlying neurobiological changes. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-22
Structured Genome-Wide Association Studies with Bayesian Hierarchical Variable Selection
39/100 ✓ Peer-reviewed Genetics Genetics
Key finding: It becomes increasingly important in using genome-wide association studies (GWAS) to select important genetic information associated with qualitative or quantitative traits. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-04-22
Oxidative Stress: A Key Modulator in Neurodegenerative Diseases
41/100 ✓ Peer-reviewed Disease mechanisms Molecules (Basel, Switzerland)
Key finding: Various neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), among others, can be the result of biochemical alteration (due to oxidative stress) in bimolecular components.
Full summary, score breakdown and related studies → Original source
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2019-04-22
Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer's Disease
57/100 ✓ Peer-reviewed Getting a diagnosis Alzheimer's research & therapy
Key finding: The cerebrospinal fluid (CSF) biochemical markers (biomarkers) Amyloidβ 42 (Aβ 42 ), total Tau (T-tau) and Tau phosphorylated at threonine 181 (P-tau 181 ) have proven diagnostic accuracy for mild cognitive impairment and dementia due to Alzheimer's Disease (AD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-21
Associations between sleep duration and cognitive impairment in mild cognitive impairment
50/100 ✓ Peer-reviewed Risk factors Journal of sleep research
Key finding: The prevalence of mild cognitive impairment (MCI) increases among elderly people and is associated with a high risk of dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-21
An Old Man's Love
27/100 ✓ Peer-reviewed Risk factors Academic Emergency Medicine
Key finding: She's waiting for me to come home, I heard again. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-21
Natural Language Processing for the Identification of Silent Brain Infarcts From Neuroimaging Reports
42/100 ✓ Peer-reviewed Digital health tools JMIR medical informatics
Key finding: Features for rule-based systems, including significant words and patterns related to SBI, were generated using pointwise mutual information. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-20
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease
56/100 ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica
Key finding: One of the key molecules involved in microglial activation is galectin-3 (gal3), and we demonstrate here for the first time a key role of gal3 in AD pathology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-19
Formaldehyde, Epigenetics, and Alzheimer's Disease
39/100 ✓ Peer-reviewed Drug development Chemical research in toxicology
Key finding: Recent studies suggest that elevation of FA in the body by endogenous and/or exogenous exposure may play important roles in AD development. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-04-19
GBA , Gaucher Disease, and Parkinson's Disease: From Genetic to Clinic to New Therapeutic Approaches
41/100 ✓ Peer-reviewed Brain scans and imaging Cells
Key finding: GBA mutations are the most common genetic risk factor of the disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-19
Taking Care of the Dyad: Frequency of Caregiver Assessment Among Veterans with Dementia
56/100 ✓ Peer-reviewed Treatments Journal of the American Geriatrics Society
Key finding: Healthcare providers identified caregivers in most of the sample, but less than 50% assessed their well-being and needs. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-04-18
Exercise as a prescription for patients with various diseases
41/100 ✓ Peer-reviewed Prevention trials Journal of sport and health science
Key finding: Because each sport has its own set of characteristics and physiological complications that tend to occur during exercise training, the effects and underlying mechanisms of exercise remain unclear. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-18
A Single-Channel EEG-Based Approach to Detect Mild Cognitive Impairment via Speech-Evoked Brain Responses
48/100 ✓ Peer-reviewed Digital health tools IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Key finding: Best results (leave-one-out cross-validation accuracy 87.9%, sensitivity 84.8%, specificity 95%, and F score 85%) were obtained using support vector machine (SVM) method with radial basis kernel (RBF) (sigma = 10/cost = 10 2 ). +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-17
Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model
39/100 ✓ Peer-reviewed Disease mechanisms Free radical biology & medicine
Key finding: Nevertheless, molecular mechanisms by which VLCFA result in toxicity remain unclear.
Full summary, score breakdown and related studies → Original source
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2019-04-17
Management of Dysphagia in Patients with Parkinson's Disease and Related Disorders
41/100 ✓ Peer-reviewed Clinical safety Internal medicine (Tokyo, Japan)
Key finding: Nutrition combined with nasogastric tube feeding or percutaneous endoscopic gastrostomy feeding should be considered owing to the increased risk of aspiration and difficulty administrating oral nutrition.
Full summary, score breakdown and related studies → Original source
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2019-04-17
Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis
81/100 ✓ Peer-reviewed Risk factors BMJ (Clinical research ed.)
Key finding: In analyses that addressed bias due to reverse causation, physical inactivity was not associated with all-cause dementia or Alzheimer's disease, although an indication of excess dementia risk was observed in a subgroup of physically inactive individuals who developed cardiometabolic disease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-04-17
The silent epidemic of chronic pain in older adults
48/100 ✓ Peer-reviewed Caregiving Progress in neuro-psychopharmacology & biological psychiatry
Key finding: Chronic pain is highly prevalent among older adults where it is associated with significant suffering, disability, social isolation, and greater costs and burden to health care systems. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-04-16
Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer's Disease Through Activation of BDNF-TrkB Signaling Pathway
41/100 ✓ Peer-reviewed Biomarkers Frontiers in pharmacology
Key finding: Alzheimer's disease (AD), a progressive neurodegenerative disease characterized by impairments of cognitive function as a result of synaptic deficits and neuronal loss, is associated with inflammation. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-04-15
The role of gut microbiota in pathogenesis of Alzheimer's disease
39/100 ✓ Peer-reviewed Disease mechanisms Journal of applied microbiology
Key finding: The diversity of the gut microbiota declines in the elderly and in patients with Alzheimer's disease (AD). +4 more findings
Full summary, score breakdown and related studies → Original source
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