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Associations between sleep duration and cognitive impairment in mild cognitive impairment
Maria Basta, Panagiotis Simos, Alexandros Vgontzas, Eirini Koutentaki, Sophia Tziraki, Ioannis Zaganas, Symeon Panagiotakis, Stefania Kapetanaki et al.. Journal of sleep research, 2019-04-21
Topic: Brain imaging, connectivity and assessment
The prevalence of mild cognitive impairment (MCI) increases among elderly people and is associated with a high risk of dementia. Identifying factors that may contribute to the progress of MCI to dementia is critical. The objective of this study was to examine the association of objective sleep with cognitive performance in MCI patients. A subsample of 271 participants with a diagnosis of probable Alzheimer's disease (AD; N = 50) or mild cognitive impairment (MCI; N = 121) and 100 persons who were not cognitively impaired (NI) were recruited from a large population-based cohort in the island of Crete, Greece (3140 older adults aged >60 years). All participants underwent extensive neuropsychiatric/neuropsychological evaluation and a 3-day 24-hr actigraphy. Objective sleep variables and their association with neuropsychological performance were examined across the three groups, controlling for demographics, body mass index, depression, sleep apnea symptoms and psychotropic medications. Patients with AD had significantly longer 24-hr total sleep time (TST) compared to the MCI and NI groups. Long 24-hr TST was associated with reduced performance on tasks that placed significant demands on attention and processing speed in the MCI group and the AD group. Elderly patients with MCI have similar objective sleep duration to normal controls, whereas AD patients sleep longer. Long sleep duration in patients with multidomain subtypes of MCI is associated with critical non-memory cognitive domains. It appears that within the MCI group those that sleep longer have more severe cognitive impairment.
Key findings
- The prevalence of mild cognitive impairment (MCI) increases among elderly people and is associated with a high risk of dementia.
- Patients with AD had significantly longer 24-hr total sleep time (TST) compared to the MCI and NI groups.
- Long 24-hr TST was associated with reduced performance on tasks that placed significant demands on attention and processing speed in the MCI group and the AD group.
- Long sleep duration in patients with multidomain subtypes of MCI is associated with critical non-memory cognitive domains.
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Study details
- Participants50
- Evidence strengthModerate
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 28 of the 56 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of sleep research) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 50 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31006940) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 28 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 28 of the 56 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
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APA 7th
Basta, M., Simos, P., Vgontzas, A., Koutentaki, E., Tziraki, S., Zaganas, I., et al. (2019). Associations between sleep duration and cognitive impairment in mild cognitive impairment. Journal of sleep research. https://doi.org/10.1111/jsr.12864
Vancouver
Basta M, Simos P, Vgontzas A, Koutentaki E, Tziraki S, Zaganas I, et al. Associations between sleep duration and cognitive impairment in mild cognitive impairment. Journal of sleep research. 2019. doi:10.1111/jsr.12864. PMID: 31006940.
BibTeX
@article{basta2019-31006940,
author = {Basta, Maria and Simos, Panagiotis and Vgontzas, Alexandros and Koutentaki, Eirini and Tziraki, Sophia and Zaganas, Ioannis and Panagiotakis, Symeon and Kapetanaki, Stefania and others},
title = {{Associations between sleep duration and cognitive impairment in mild cognitive impairment}},
journal = {Journal of sleep research},
year = {2019},
doi = {10.1111/jsr.12864},
pmid = {31006940},
url = {https://doi.org/10.1111/jsr.12864}
}