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Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review
Nascimento PC, Castro MML, Magno MB, Almeida APCPSC, Fagundes NCF, Maia LC, Lima RR.. Frontiers in neurology, 2019-04-24
Topic: Risk, prevention and care in population studies
Periodontitis is an oral inflammatory disease and may contribute to low-grade systemic inflammation. Based on the contribution of periodontitis to systemic inflammation and the potential role of systemic inflammation in neuroinflammation, many epidemiological studies have investigated a possible association between periodontitis and mild cognitive impairment or dementia. The purpose of this study was to evaluate the clinical/epidemiological evidence regarding the association between periodontitis and cognitive decline in adult patients. A search conducted between September and October 2018 was performed in the electronic databases PubMed, Scopus, Web of Science, The Cochrane Library, LILACS, OpenGrey, and Google Scholar, with no publication date or language restrictions. Analytical observational studies in adults (P-Participants), with (E-Exposure) and without periodontitis (C-Comparison) were included in order to determine the association between periodontitis and cognitive decline (O-Outcome). The search identified 509 references, of which eight observational studies were accorded with the eligibility criteria and evaluated. The results should, however, be interpreted cautiously due to the limited number of studies. This systematic review points to the need for further well-designed studies, such as longitudinal observational studies with control of modifiable variables, as diagnostic criteria and time since diagnosis of periodontitis and cognitive impairment, to confirm the proposed association.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Nascimento, P. C., Castro, M. M. L., Magno, M. B., APCPSC, A., Fagundes, N. C. F., Maia, L. C., et al. (2019). Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review. Frontiers in neurology. https://doi.org/10.3389/fneur.2019.00323
Vancouver
Nascimento PC, Castro MML, Magno MB, APCPSC A, Fagundes NCF, Maia LC, et al. Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review. Frontiers in neurology. 2019. doi:10.3389/fneur.2019.00323. PMID: 31105630.
BibTeX
@article{nascimento2019-31105630,
author = {Nascimento, P. C. and Castro, M. M. L. and Magno, M. B. and APCPSC, Almeida and Fagundes, N. C. F. and Maia, L. C. and Lima, R. R.},
title = {{Association Between Periodontitis and Cognitive Impairment in Adults: A Systematic Review}},
journal = {Frontiers in neurology},
year = {2019},
doi = {10.3389/fneur.2019.00323},
pmid = {31105630},
url = {https://doi.org/10.3389/fneur.2019.00323}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- The results should, however, be interpreted cautiously due to the limited number of studies.
Why it matters
Screening 509 references, this review found eight observational studies on whether periodontitis, an inflammatory gum disease, is linked to cognitive decline in adults. The authors caution that the results must be read carefully because so few studies exist, and call for better-designed long-term studies to confirm the proposed association.
Study details
- Study designsystematic review
- Evidence strengthHigh
How this study scored 57/100
Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for sample size, effect reported and studied in people because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in neurology) |
| Journal's citation record | 2 / 4 | Frontiers in Neurology: journal h-index 162 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A systematic review of all the studies on the question |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | 4 / 7 | Cited 52 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.8 citations a year over 9 year(s) since 2019 |
| Impact for its field and year | 2 / 6 | Cited 1.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 2 / 4 | Cited 22 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Rafael Rodrigues Lima: h-index 44 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Alberta: institution h-index 1,174 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31105630) |
| Free to read | 2 / 2 | Free to read |
| Total | 57 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3389/fneur.2019.00323
- PubMed: 31105630
- Original source →
- Free full text: Frontiers in Neurology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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