Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,651–12,675 of 27,380 studies, newest first · page 507 of 1096.
July 2019 25
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2019-07-17
Effects of Anserine/Carnosine Supplementation on Mild Cognitive Impairment with APOE4
73/100 ✓ Peer-reviewed Clinical trials Nutrients
Key finding: The score improvement in the global Clinical Dementia Rating (gloCDR) was superior in the active group than placebo (p = 0.023). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-17
Insights into Computational Drug Repurposing for Neurodegenerative Disease
39/100 ✓ Peer-reviewed Drug development Trends in pharmacological sciences
Key finding: Computational drug repurposing has the ability to remarkably reduce drug development time and cost in an era where these factors are prohibitively high. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-17
Liver Dysfunction as a Novel Player in Alzheimer's Progression: Looking Outside the Brain
41/100 ✓ Peer-reviewed Disease mechanisms Frontiers in aging neuroscience
Key finding: The effect of BBB impairment on Aβ, and whether BBB function is affected by non-neurological pathologies that impair peripheral clearance requires further investigation. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-17
Cerebrospinal Fluid Markers of Synaptic Injury and Functional Connectivity in Alzheimer Disease: Protocol for a Cross-Sectional Study
37/100 ✓ Peer-reviewed Tau biomarkers JMIR research protocols
Key finding: Synaptic loss is the best surrogate for cognitive decline in Alzheimer disease (AD) and is more closely associated with cognitive function than amyloid or tau pathologies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-17
The Emerging Role of Triggering Receptor Expressed on Myeloid Cells 2 as a Target for Immunomodulation in Ischemic Stroke
42/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in immunology
Key finding: It is characterized by loss of neural tissue in which inflammation plays a crucial role in both the acute contribution to ischemic damage as in the late-stage impact on post-ischemic tissue regeneration. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-16
Care Home Life and Identity: A Qualitative Case Study
39/100 ✓ Peer-reviewed Health systems and care delivery The Gerontologist
Key finding: Four themes were identified: (a) changing with age, (b) independence and autonomy, (c) bounded identity, and (d) social comparison. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-16
Targeting Synaptic Plasticity in Experimental Models of Alzheimer's Disease
39/100 ✓ Peer-reviewed Disease mechanisms Frontiers in pharmacology
Key finding: Alterations of synaptic plasticity are observed in several neurodegenerative disorders, including Alzheimer's disease (AD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-16
Attitudes toward advance care planning among persons with dementia and their caregivers
45/100 ✓ Peer-reviewed End-of-life care International psychogeriatrics
Key finding: Educational programs may be useful in reducing racial differences in attitudes towards ACP. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-07-16
Validation of neuropsychological tests for the China Health and Retirement Longitudinal Study Harmonized Cognitive Assessment Protocol
61/100 ✓ Peer-reviewed Cognitive tests and assessment International psychogeriatrics
Key finding: We recruited 825 individuals from the CHARLS sample and 766 subjects from hospitals in six provinces and cities in China. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-16
In vivo Prevalence of Alzheimer Biomarkers in Dementia with Lewy Bodies
42/100 ✓ Peer-reviewed Tau biomarkers Dementia and geriatric cognitive disorders
Key finding: Neuropathological studies indicate concomitant Alzheimer's disease (AD) pathology in patients with dementia with Lewy bodies (DLB). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-16
A Novel Ensemble-Based Machine Learning Algorithm to Predict the Conversion From Mild Cognitive Impairment to Alzheimer's Disease Using Socio-Demographic Characteristics, Clinical Information, and Neuropsychological Measures
51/100 ✓ Peer-reviewed Digital health tools Frontiers in neurology
Key finding: The final algorithm demonstrated an AUROC of 0.88, sensitivity of 77.7%, and a specificity of 79.9% on excluded test data. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-13
In search of pathogenic amyloid β-peptide in familial Alzheimer's disease
39/100 ✓ Peer-reviewed Risk genes beyond APOE Progress in molecular biology and translational science
Key finding: Early-onset familial Alzheimer's disease (FAD) is pathologically and clinically similar to the more common late-onset sporadic form of the disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-13
Transcriptional regulation of homeostatic and disease-associated-microglial genes by IRF1, LXRβ, and CEBPα
39/100 ✓ Peer-reviewed TREM2 and immune genetics Glia
Key finding: Within DAM, we recently identified distinct pro-inflammatory and anti-inflammatory sub-profiles although transcriptional regulators of homeostatic and distinct DAM profiles remain unclear. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-12
Geographical Variation in Opioid Use in Elderly Patients with Dementia: A Nationwide Study
53/100 ✓ Peer-reviewed Risk factors Journal of Alzheimer s Disease
Key finding: 32.5% of elderly with dementia and 16.9% without were treated with an opioid in 2015. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-11
Epidemiology of Vascular Dementia
53/100 ✓ Peer-reviewed Prevention and risk Arteriosclerosis, thrombosis, and vascular biology
Key finding: The consequent limitations of nosology may be alleviated by addition of a vascular component to the recently introduced amyloid/tau/neurodegeneration etiological classification system for dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-10
[Breathing: Ambient Air Pollution and Health - Part III]
39/100 ✓ Peer-reviewed Risk factors Pneumologie (Stuttgart, Germany)
Key finding: The third part of the DGP statement introduces the current body of knowledge on less studied health outcomes associated with exposure to ambient air pollution: the negative impact on metabolism leading to impaired glucose tolerance and diabetes as well as contribution to the development of neurodegenerative disorders and delayed cognitive function in children. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-10
Alzheimer's disease medication and risk of all-cause mortality and all-cause hospitalization: A retrospective cohort study
71/100 ✓ Peer-reviewed Treatments Alzheimer's & dementia (New York, N. Y.)
Key finding: In our final study sample (N = 21,558), significant difference in survival among index AD medication groups were observed with donepezil being associated with better survival than memantine, and oral and transdermal forms of rivastigmine for both ITT and as-treated analysis. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-10
Functional and/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements - a systematic review
69/100 ✓ Peer-reviewed Prevention trials European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity
Key finding: During the aging process, physical capabilities (e.g., muscular strength) and cognitive functions (e.g., memory) gradually decrease. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-07-10
The Nutritional Components of Beer and Its Relationship with Neurodegeneration and Alzheimer's Disease
41/100 ✓ Peer-reviewed Prevention trials Nutrients
Key finding: Growing evidence suggests that demenia and other cognition affectations are associated with ambient factors including specific nutrients, food ingredients or specific dietary patterns. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-10
Computer-based cognitive training for older adults: Determinants of adherence
78/100 ✓ Peer-reviewed Prevention trials PloS one
Key finding: Our aim is to investigate older adults´ adherence to a long-term CCT program, and which participant characteristics are associated with adherence to the CCT. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-10
A Review of the Molecular Mechanisms of Traumatic Brain Injury
42/100 ✓ Peer-reviewed Inflammation and the immune system World neurosurgery
Key finding: Secondary damage is often linked to the molecular mechanisms that occur post TBI and result in excitotoxicity, neuroinflammation and cytokine damage, oxidative damage, and eventual cell death as prominent mechanisms of cell damage. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-10
TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease
56/100 ✓ Peer-reviewed TREM2 and immune genetics Neuron
Key finding: Here, we investigated crosstalk between CD33 and TREM2. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-09
Alzheimer's disease drug development pipeline: 2019
45/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (New York, N. Y.)
Key finding: Drug development continues robustly at all phases despite setbacks in several programs in the recent past. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-07-09
Heart Rate Variability and Cognitive Function: A Systematic Review
81/100 ✓ Peer-reviewed Vascular contributions Frontiers in neuroscience
Key finding: Both increased sympathetic activity and decreased parasympathetic activity seem to be associated with a worse performance in the cognitive domains considered, in the absence of dementia and severe cardiovascular diseases or other medical and psychiatric diseases. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-09
Interventions to optimize prescribing for older people in care homes
34/100 ✓ Peer-reviewed Health systems and care delivery International Journal of Nursing Practice
Key finding: Within this projection, the number of persons aged 80 years or over will increase more than threefold, increasing from 137 million to 425 million (United Nations, 2017). \n \nGrowing old is often accompanied by a higher prevalence of medical conditions which can result in the development of moderate to severe functional and/or cognitive impairments to the extent that long‐term accommodation and care is needed.
Full summary, score breakdown and related studies → Original source
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