Newest studies

Practice Guidelines for the Management of Community-Acquired Pneumonia in Adults

70/100 ✓ Peer-reviewed Risk factors Clinical Infectious Diseases

Key finding: The of establishing the diagnosis of pneumonia and cause is with the antibiotic studies for of community-acquired studies for of community-acquired The diagnosis of is based on a of clinical and laboratory The diagnosis of is and and as well as disease, congestive heart failure, with pneumonia and cases of and are of do not require and are the of antibiotic antimicrobial is usually for and a chest radiography is usually to establish the diagnosis of examination to or is for detecting pneumonia Chest radiography is considered is for the etiologic the and or conditions. +4 more findings

• Clinical Trials

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Hippocampal volume in geriatric depression

58/100 ✓ Peer-reviewed Brain tissue and pathology Biological psychiatry

Key finding: There is a growing literature on the importance of hippocampal volume in geriatric depression. +3 more findings

• Brain Scans

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

55/100 ✓ Peer-reviewed Risk genes beyond APOE Nature medicine

Key finding: Mice transgenic for an amyloid beta precursor protein (APP) mini-gene driven by a platelet-derived (PD) growth factor promoter (PDAPP mice), which overexpress one of the disease-linked mutant forms of the human amyloid precursor protein, show many of the pathological features of Alzheimer disease, including extensive deposition of extracellular amyloid plaques, astrocytosis and neuritic dystrophy. +3 more findings

• Brain Biology

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Neuropathology in mice expressing human alpha-synuclein

47/100 ✓ Peer-reviewed Lewy body dementia The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: Motor neuron pathology included axonal damage and denervation of neuromuscular junctions in several muscles examined, suggesting that alpha-synuclein interfered with a universal mechanism of synapse maintenance.

• Brain Biology
• Other Dementias
• Genetics

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The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

46/100 ✓ Peer-reviewed Lewy body dementia The Journal of neuroscience : the official journal of the Society for Neuroscience

Key finding: The mechanisms underlying PD are unknown, but the discoveries that mutations in alpha-synuclein can cause familial PD and that alpha-synuclein accumulates in Lewy bodies suggest that alpha-synuclein participates in the pathophysiology of PD.

• Genetics
• Other Dementias
• Side Effects

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Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

56/100 ✓ Peer-reviewed Lewy body dementia Nature genetics

Key finding: Mutations in the gene (Mtapt) encoding tau protein cause frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), thereby proving that tau dysfunction can directly result in neurodegeneration. +1 more finding

• Brain Biology
• Other Dementias

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Tau protein isoforms, phosphorylation and role in neurodegenerative disorders

54/100 ✓ Peer-reviewed Lewy body dementia Brain research. Brain research reviews

Key finding: Molecular analysis has revealed that an abnormal phosphorylation might be one of the important events in the process leading to their aggregation. +1 more finding

• Other Dementias
• Brain Biology

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Association between presenilin-1 polymorphism and maternal meiosis II errors in Down syndrome

41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of medical genetics

Key finding: A genetic association between a polymorphism in intron 8 of the PS-1 gene and AD has been described in some series, and an increased risk of AD has been reported in mothers of DS probands. +1 more finding

• Down Syndrome
• Genetics

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Patterns of brain activation in people at risk for Alzheimer's disease

62/100 ✓ Peer-reviewed Risk factors The New England journal of medicine

Key finding: Both the magnitude and the extent of brain activation during memory-activation tasks in regions affected by Alzheimer's disease, including the left hippocampal, parietal, and prefrontal regions, were greater among the carriers of the APOE epsilon4 allele than among the carriers of the APOE epsilon3 allele.

• Risk Factors
• Brain Scans
• Genetics

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Motor impairment in PD: relationship to incident dementia and age

56/100 ✓ Peer-reviewed Digital health tools Neurology

Key finding: Of 173 patients followed for at least 1 year, 50 became demented according to the Diagnostic and Statistical Manual of Mental Disorders, revised 3rd edition (DSM III-R) criteria (mean follow-up, 3.6 +/- 2. 2 years). +4 more findings

• Risk Factors

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The therapeutic design of environments for people with dementia: a review of the empirical research

44/100 ✓ Peer-reviewed Caregiving The Gerontologist

Key finding: Design of the physical environment is increasingly recognized as an important aid in caring for people with dementia. +2 more findings

• Caregiving

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Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease?

53/100 ✓ Peer-reviewed Getting a diagnosis Journal of neurology, neurosurgery, and psychiatry

Key finding: Factor analysis showed four robust and meaningful symptom clusters: factor 1-stereotypic and eating behaviour; factor 2-executive dysfunction and self care; factor 3-mood changes; factor 4-loss of social awareness. +3 more findings

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Pharmacologic Therapy for Type 2 Diabetes Mellitus

66/100 ✓ Peer-reviewed Drug development Annals of Internal Medicine

DeFronzo Metrics Cited ByDiscovery of α-Glucosidase Inhibitors from Marine Microorganisms: Optimization of Culture Conditions and Medium CompositionBurdock fructooligosaccharide as an α-glucosidase inhibitor and its antidiabetic effect on high-fat diet and streptozotocin-induced diabetic miceThe antioxidant and antidiabetic potentials of polyphenolic-rich extracts of Cyperus rotundus (Linn.)From Pharmacogenetics to Gene Expression: Implications for Precision Medicine in DiabetesA narrative review of current trends in liraglutide: insights into the unmet needs in management of type 2 diabetes and obesitySynthesis, antidiabetic, antioxidant and anti-inflammatory activities of novel hydroxytriazenes based on sulpha drugsRNA-Seq Analysis of the Liver Transcriptome Reveals the Networks Regulating Treatment of Sitagliptin Phosphate plus Fuzhujiangtang Granule in the Zucker Diabetic Fatty RatsEverestmab, a novel long-acting GLP-1/anti GLP-1R nanobody fusion protein, exerts potent anti-diabetic effectsSPION‐Decorated Exosome Delivered BAY55‐9837 Targeting the Pancreas through Magnetism to Improve the Blood GLC ResponseA novel self-sufficient biocatalyst based on transaminase and pyridoxal 5′-phosphate covalent co-immobilization and its application in continuous biosynthesis of sitagliptinShared Pathological Mechanisms Between Diabetes Mellitus and Neurodegenerative DiseasesEffects of Lifestyle Modification and Anti-diabetic Medicine on Prediabetes Progress: A Systematic Review and Meta-AnalysisGlibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 PolarizationNaringin enhances reverse cholesterol transport in high fat/low streptozocin induced diabetic ratsA novel strategy to prepare the precursor peptide of liraglutideImpact of metformin on patients with advanced head and neck cancer undergoing concurrent chemoradiotherapyEffects of Different Doses of Metformin on Serum Fatty Acid Composition in Type 2 Diabetic RatsInsulin resistance and cognitive performance in type 2 diabetes — The Maastricht studyDesign and synthesis of novel thiazolidine-2,4-diones as hypoglycemic agentsMetformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical TrialMetformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysisGlibenclamide reduces pro-inflammatory cytokine production by neutrophils of diabetes patients in response to bacterial infectionNa + /H

• Treatments
• Risk Factors

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The quality of residential and nursing-home care for people with dementia

38/100 ✓ Peer-reviewed Health systems and care delivery Age and ageing

Key finding: over 90% of the homes had high quality scores on at least two measures. +3 more findings

• Care Services

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Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases

36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neurobiology of aging

Key finding: It was not associated with tau-containing inclusions in astroglia and oligodendroglia in PPND, PSP, and PDC. +1 more finding

• Other Dementias
• Brain Biology

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DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Human molecular genetics

Key finding: Together, these results suggest that members of this newly described family of human proteins are endogenous regulators of calcineurin-mediated signaling pathways and as such, they may be involved in many physiological processes.

• Down Syndrome

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Oxidative stress in Alzheimer's disease

36/100 ✓ Peer-reviewed Genetics Biochimica et biophysica acta

Key finding: Examination of Alzheimer's disease brain has demonstrated a great deal of oxidative damage, associated with both hallmark pathologies (senile plaques and neurofibrillary tangles) as well as in normal appearing pyramidal neurons. +1 more finding

• Brain Biology
• Genetics

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Poststroke dementia : clinical features and risk factors

41/100 ✓ Peer-reviewed Vascular contributions Stroke

Key finding: Dementia is frequent after ischemic or hemorrhagic stroke. +1 more finding

• Risk Factors
• Diagnosis

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Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype

55/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology

Key finding: The epsilon4 allele of the apolipoprotein E (APOE) gene confers an increased risk for the development of AD. +2 more findings

• Genetics
• Brain Scans

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Survival in end-stage dementia following acute illness

64/100 ✓ Peer-reviewed End-of-life care JAMA

Key finding: In this study, patients with advanced dementia and hip fracture or pneumonia had a very poor prognosis. +2 more findings

• End-of-Life Care

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Psychiatric illness predicts poor outcome after surgery for hip fracture: a prospective cohort study

52/100 ✓ Peer-reviewed Clinical safety Psychological medicine

Key finding: Psychiatric illness is common after hip fracture, and has significant effects on important outcomes. +2 more findings

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Alpha-synuclein inclusions in amygdala in the brains of patients with the parkinsonism-dementia complex of Guam

36/100 ✓ Peer-reviewed Disease mechanisms Journal of neuropathology and experimental neurology

Key finding: Thus, the present study suggests that a common mechanism may govern aggregation of alpha-synuclein and tau in the amygdala, and that aggregation of alpha-synuclein may play some role in the neurodegenerative process of a tauopathy (i.e.

• Brain Biology
• Other Dementias

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Lewy Bodies in Alzheimer's Disease: A Neuropathological Review of 145 Cases Using α‐Synuclein Immunohistochemistry

47/100 ✓ Peer-reviewed Brain tissue and pathology Brain Pathology

Antibodies to alpha-synuclein (AS) now provide a sensitive and specific method for the detection of Lewy bodies (LBs) and their use will allow a more accurate determination of the prevalence of LBs in Alzheimer's Disease (AD).

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Gene-expression profile of the ageing brain in mice

53/100 ✓ Peer-reviewed Inflammation and the immune system Nature genetics

Key finding: Recent studies suggest that normal brain ageing is associated with subtle morphological and functional alterations in specific neuronal circuits, as opposed to large-scale neuronal loss. +3 more findings

• Brain Biology

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Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

45/100 ✓ Peer-reviewed Brain tissue and pathology Proceedings of the National Academy of Sciences of the United States of America

Key finding: HD is one of a number of diseases caused by expression of an expanded polyglutamine repeat. +3 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source