Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 15,401–15,425 of 27,380 studies, newest first · page 617 of 1096.
January 2017 25
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2017-01-18
Cerebrospinal fluid levels of orexin-A and histamine, and sleep profile within the Alzheimer process
51/100 ✓ Peer-reviewed Tau biomarkers Neurobiology of aging
Key finding: We determined the relationships between these biomarkers, the CSF AD biomarkers concentrations, and the clinical sleep profile. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-18
Post-stroke dementia - a comprehensive review
57/100 ✓ Peer-reviewed Prevention and risk BMC medicine
Key finding: Quantitative imaging of cerebral blood flow and metabolism by positron emission tomography can differentiate between vascular dementia and degenerative dementia and show the interaction between vascular and metabolic changes. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-17
Diagnostic impact of [18F]flutemetamol PET in early-onset dementia
49/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's research & therapy
Key finding: [18F]flutemetamol PET scans were positive in 133 out of 211 (63%) patients, of whom 110 out of 144 (76%) patients had a pre-PET Alzheimer's disease (AD) diagnosis and 23 out of 67 (34%) patients had a non-AD diagnosis. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-17
Factors predicting incidence of post-operative delirium in older people following hip fracture surgery: a systematic review and meta-analysis
64/100 ✓ Peer-reviewed Disparities International journal of geriatric psychiatry
Key finding: Clinicians treating people with a hip fracture should be vigilant towards post-operative delirium if their patients are older, have pre-existing cognitive impairment and poorer overall general health. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-17
Long-term hormone therapy for perimenopausal and postmenopausal women
71/100 ✓ Peer-reviewed Prevention and risk The Cochrane database of systematic reviews
Key finding: We included 22 studies involving 43,637 women. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-17
Nutritional Considerations for Healthy Aging and Reduction in Age-Related Chronic Disease
52/100 ✓ Peer-reviewed Prevention and risk Advances in nutrition (Bethesda, Md.)
Key finding: Burdens of unhealthy aging associated with chronic noncommunicable and other age-related diseases may be largely preventable with lifestyle modification, including diet.
Full summary, score breakdown and related studies → Original source
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2017-01-16
Technologies to Support Community-Dwelling Persons With Dementia: A Position Paper on Issues Regarding Development, Usability, Effectiveness and Cost-Effectiveness, Deployment, and Ethics
41/100 ✓ Peer-reviewed Costs and economics JMIR rehabilitation and assistive technologies
Key finding: Based on these findings, various actions are recommended for development, usability, effectiveness and cost-effectiveness, deployment, and ethics of assistive and health technologies across Europe. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-01-16
The role of peripheral immune cells in the CNS in steady state and disease
41/100 ✓ Peer-reviewed Vascular contributions Nature neuroscience
Key finding: The CNS is protected by the immune system, including cells that reside directly within the CNS and help to ensure proper neural function, as well as cells that traffic into the CNS with disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-16
Interactions between the microbiota, immune and nervous systems in health and disease
41/100 ✓ Peer-reviewed Risk factors Nature neuroscience
Key finding: Studies investigating the gut-brain axis demonstrate a critical role for the gut microbiota in orchestrating brain development and behavior, and the immune system is emerging as an important regulator of these interactions. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-16
Case-control association mapping by proxy using family history of disease
81/100 ✓ Peer-reviewed Genetics Nature genetics
Key finding: In addition to informing disease biology, our results demonstrate the utility of association mapping without directly observing cases.
Full summary, score breakdown and related studies → Original source
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2017-01-14
Enhancing Cognitive Functioning in Healthly Older Adults: a Systematic Review of the Clinical Significance of Commercially Available Computerized Cognitive Training in Preventing Cognitive Decline
66/100 ✓ Peer-reviewed Prevention trials Neuropsychology review
Key finding: Two programs were identified as possessing Level I evidence, three programs demonstrated Level II evidence and an additional two programs demonstrated Level III evidence. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-01-13
Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons
38/100 ✓ Peer-reviewed Risk factors Neurobiology of aging
Key finding: Traffic-related air pollution (TRAP) is associated with lower cognition and reduced white matter volume in older adults, specifically for particulate matter <2.5-μm diameter (PM 2.5 ).
Full summary, score breakdown and related studies → Original source
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2017-01-13
Urinary incontinence and its association with functional physical and cognitive health among female nursing home residents in Switzerland
60/100 ✓ Peer-reviewed Prevention trials BMC geriatrics
Key finding: The study indicated that impairment in ADL performance is strongly associated with UI, more than CPS performance and comorbidities. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-12
Finding the imposter: brain connectivity of lesions causing delusional misidentifications
69/100 ✓ Peer-reviewed Clinical safety Brain : a journal of neurology
Key finding: We found that all 17 lesion locations were functionally connected to the left retrosplenial cortex, the region most activated in functional magnetic resonance imaging studies of familiarity. +2 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-11
Tunicamycin impairs olfactory learning and synaptic plasticity in the olfactory bulb
39/100 ✓ Peer-reviewed Disease mechanisms Neuroscience
Key finding: ER stress is associated with neuronal death in neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease, and most patients complain of the impairment of olfactory recognition. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-11
Overlay of Late-Life Depression and Cognitive Impairment
39/100 ✓ Peer-reviewed Risk factors Focus (American Psychiatric Publishing)
Key finding: Articles included are seminal articles from the field as well as representative, heuristic studies. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-11
TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway
52/100 ✓ Peer-reviewed TREM2 and immune genetics The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: TREM2 transmits intracellular signals through its transmembrane binding partner DNAX-activating protein 12 (DAP12). +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-10
Metabolic syndrome, hypertension, and nervous system injury: Epidemiological correlates
39/100 ✓ Peer-reviewed Risk factors Clinical and experimental hypertension (New York, N.Y. : 1993)
Key finding: Metabolic syndrome (MetS) is a common and complex disorder combining hypertension, obesity, dyslipidemia, and insulin resistance. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-01-10
Tau passive immunization inhibits not only tau but also Aβ pathology
41/100 ✓ Peer-reviewed Drug development Alzheimer's research & therapy
Key finding: These findings suggest the potential of passive immunization targeting proximal N-terminal domain tau 6-18 as a disease-modifying approach to AD and related tauopathies. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-01-09
PRagmatic trial Of Video Education in Nursing homes: The design and rationale for a pragmatic cluster randomized trial in the nursing home setting
74/100 ✓ Peer-reviewed End-of-life care Clinical trials (London, England)
Key finding: The large number of well-characterized candidate facilities enabled several unique design features including stratification on historical hospitalization rates, randomization prior to recruitment, and 2:1 control to intervention facilities ratio.
Full summary, score breakdown and related studies → Original source
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2017-01-09
Behavioural and psychological symptoms in general hospital patients with dementia, distress for nursing staff and complications in care: results of the General Hospital Study
55/100 ✓ Peer-reviewed Clinical safety Epidemiology and psychiatric sciences
Key finding: BPSD are common in older hospital patients with dementia and associated with considerable distress in nursing staff, as well as a wide range of special treatments needs and additional behavioural and medical complications. +4 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-09
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network
48/100 ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica
Key finding: Genetic studies demonstrate an association of the common GRN rs5848 variant that results in reduced PGRN levels with increased risk for AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-09
The Built Environment and Cognitive Disorders: Results From the Cognitive Function and Ageing Study II
58/100 ✓ Peer-reviewed Disparities American journal of preventive medicine
Key finding: Non-linear associations between features of land use and cognitive impairment were confirmed in this new cohort of older people in England. +3 more findings
Full summary, score breakdown and related studies → Original source
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2017-01-05
Derivation and Internal Validation of a Clinical Prediction Tool for 30-Day Mortality in Lower Gastrointestinal Bleeding
52/100 ✓ Peer-reviewed Digital health tools The American journal of medicine
Key finding: A clinical tool can be used to predict 30-day mortality in patients hospitalized with lower gastrointestinal bleeding. +1 more finding
Full summary, score breakdown and related studies → Original source
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2017-01-05
Living near major roads and the incidence of dementia, Parkinson's disease, and multiple sclerosis: a population-based cohort study
70/100 ✓ Peer-reviewed How common it is Lancet (London, England)
Key finding: Between 2001, and 2012, we identified 243 611 incident cases of dementia, 31 577 cases of Parkinson's disease, and 9247 cases of multiple sclerosis. +2 more findings
Full summary, score breakdown and related studies → Original source
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