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Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model
Margaux Doria, Thomas Nury, Dominique Delmas, Thibault Moreau, Gérard Lizard, Anne Vejux. Free radical biology & medicine, 2019-04-17
Topic: Disease mechanisms in lab and animal studies
In recent years, a particular interest has focused on the accumulation of fatty acids with very long chains (VLCFA) in the occurrence of neurodegenerative diseases such as Alzheimer's disease, multiple sclerosis or dementia. Indeed, it seems increasingly clear that this accumulation of VLCFA in the central nervous system is accompanied by a progressive demyelination resulting in death of neuronal cells. Nevertheless, molecular mechanisms by which VLCFA result in toxicity remain unclear. This study highlights for the first time in 3 different cellular models (oligodendrocytes 158 N, primary mouse brain culture, and patient fibroblasts) the types of cell death involved where VLCFA-induced ROS production leads to autophagy. The autophagic process protects the cell from this VLCFA-induced toxicity. Thus, autophagy in addition to oxidative stress can offer new therapeutic approaches.
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APA 7th
Doria, M., Nury, T., Delmas, D., Moreau, T., Lizard, G., & Vejux, A. (2019). Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model. Free radical biology & medicine. https://doi.org/10.1016/j.freeradbiomed.2019.04.016
Vancouver
Doria M, Nury T, Delmas D, Moreau T, Lizard G, Vejux A. Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model. Free radical biology & medicine. 2019. doi:10.1016/j.freeradbiomed.2019.04.016. PMID: 31004752.
BibTeX
@article{doria2019-31004752,
author = {Doria, Margaux and Nury, Thomas and Delmas, Dominique and Moreau, Thibault and Lizard, Gérard and Vejux, Anne},
title = {{Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model}},
journal = {Free radical biology \& medicine},
year = {2019},
doi = {10.1016/j.freeradbiomed.2019.04.016},
pmid = {31004752},
url = {https://doi.org/10.1016/j.freeradbiomed.2019.04.016}
}
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Key findings
- Nevertheless, molecular mechanisms by which VLCFA result in toxicity remain unclear.
Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 22 of the 56 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Free radical biology & medicine) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31004752) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 22 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 22 of the 56 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
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