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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 19,151–19,175 of 27,380 studies, newest first · page 767 of 1096.

October 2012 25

  1. 2012-10-12

    Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases

    ✓ Peer-reviewed Drug development Disease models & mechanisms

    Key finding: Some, but not all, studies indicate that high levels of plasma cholesterol correlate with increased risk of developing AD.

    Full summary, score breakdown and related studies → Original source

  2. 2012-10-11

    Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony

    ✓ Peer-reviewed Inflammation and the immune system Experimental neurology

    Key finding: Numerous pathological changes have been described in the postmortem brains of AD patients, including senile plaques, neurofibrillary tangles, neuroinflammation, synapse loss, and neuronal death. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2012-10-11

    Default network is not hypoactive in dementia with fluctuating cognition: an Alzheimer disease/dementia with Lewy bodies comparison

    ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging

    Key finding: Our aim was to assess whether patients with DLB with both of these features have different default mode network patterns during resting state functional magnetic resonance imaging compared with AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2012-10-11

    APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease

    ✓ Peer-reviewed Genetics The Journal of biological chemistry

    Key finding: As the introduction of human APOE significantly delays amyloid deposition in transgenic mice expressing familial AD (FAD) mutations (FAD-Tg), 5xFAD-Tg mice, which exhibit amyloid deposition by age 2 months, were crossed with apoE-targeted replacement mice to produce the new EFAD-Tg mice. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2012-10-09

    Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

    Key finding: Because cerebral deposition of Aβ species might be critical for the pathogenesis of Alzheimer disease, BACE1 has emerged as a key target for the treatment of this disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2012-10-08

    Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of medicinal chemistry

    Key finding: These approaches revealed unexpected potential secondary targets such as CK2, SLK, and the lipid kinase PIKfyve/Vac14/Fig4.

    Full summary, score breakdown and related studies → Original source

  7. 2012-10-08

    Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice

    ✓ Peer-reviewed Drug development Experimental neurology

    Key finding: Traumatic brain injury (TBI) is a global problem reaching near epidemic numbers that manifests clinically with cognitive problems that decades later may result in dementias like Alzheimer's disease (AD). +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2012-10-08

    Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

    ✓ Peer-reviewed Inflammation and the immune system The Journal of clinical investigation

    Key finding: In humans, PGRN haploinsufficiency is a major inherited cause of frontotemporal dementia (FTD), but how PGRN deficiency causes neurodegeneration is unknown. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2012-10-06

    Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

    ✓ Peer-reviewed Lewy body dementia Molecular brain

    Key finding: Pathogenic changes in the brain of a PARK2 patient were recapitulated using iPSC technology.

    Full summary, score breakdown and related studies → Original source

  10. 2012-10-05

    Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain

    ✓ Peer-reviewed Genetics Free radical biology & medicine

    Key finding: By comparing results obtained at different stages of the AD, it may be possible to identify key biochemical pathways involved and ideally identify therapeutic targets to prevent, delay, or treat AD.

    Full summary, score breakdown and related studies → Original source

  11. 2012-10-05

    Tools to detect delirium superimposed on dementia: a systematic review

    ✓ Peer-reviewed Clinical safety Journal of the American Geriatrics Society

    Key finding: The evidence base on tools for detection of delirium superimposed on dementia is limited, although some existing tools show promise.

    Full summary, score breakdown and related studies → Original source

  12. 2012-10-04

    Random forest-based similarity measures for multi-modal classification of Alzheimer's disease

    ✓ Peer-reviewed Digital health tools NeuroImage

    Key finding: Neurodegenerative disorders, such as Alzheimer's disease, are associated with changes in multiple neuroimaging and biological measures. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2012-10-04

    Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

    ✓ Peer-reviewed Biomarkers FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    Key finding: Reactive astrocytes are intimately associated with amyloid plaques; however, their role in AD pathogenesis is unclear. +2 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2012-10-04

    Neuropathologic substrates of Parkinson disease dementia

    ✓ Peer-reviewed Getting a diagnosis Annals of neurology

    Key finding: Niney-two PD patients developed dementia, and 48 remained cognitively normal. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2012-10-03

    Cognitive impairment in Parkinson's disease: the dual syndrome hypothesis

    ✓ Peer-reviewed Mild cognitive impairment Neuro-degenerative diseases

    Key finding: We conclude with an exposition of the dual syndrome hypothesis, which distinguishes between dopaminergically mediated fronto-striatal executive impairments and a dementia syndrome with distinctive prodromal visuospatial deficits in which cholinergic treatments offer some clinical benefits.

    Full summary, score breakdown and related studies → Original source

  16. 2012-10-03

    Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

    ✓ Peer-reviewed Disease mechanisms Scientific reports

    Key finding: We observed for the first time that these authentic brain-derived tau oligomers propagate abnormal tau conformation of endogenous murine tau after prolonged incubation.

    Full summary, score breakdown and related studies → Original source

  17. 2012-10-03

    Aging effects on DNA methylation modules in human brain and blood tissue

    ✓ Peer-reviewed Genetics Genome biology

    Key finding: Overall, our analysis revealed a robustly defined age-related co-methylation module that is present in multiple human tissues, including blood and brain. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2012-10-03

    The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression

    ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry

    Key finding: ADAM10 is essential for embryonic development and is also important in inflammation, cancer, and Alzheimer disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2012-10-02

    Prediction of Alzheimer's disease in subjects with mild cognitive impairment from the ADNI cohort using patterns of cortical thinning

    ✓ Peer-reviewed Mild cognitive impairment NeuroImage

    Key finding: Surface-based cortical thickness measurements from T1-weighted MRI have demonstrated high sensitivity to cortical gray matter changes. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2012-10-01

    Sinking, Swimming, or Learning to Swim in Medicare Part D

    ✓ Peer-reviewed Costs and economics American Economic Review

    Key finding: The oldest consumers and those initiating medications for Alzheimer's disease improved by more than average, suggesting that real-world institutions help overcome cognitive limitations.

    Full summary, score breakdown and related studies → Original source

  21. 2012-10-01

    The clinical features of pathologically confirmed vascular parkinsonism

    ✓ Peer-reviewed Digital health tools Journal of neurology, neurosurgery, and psychiatry

    Key finding: In comparison with other Parkinsonian syndromes the patients were older and had an extremely low frequency of visual hallucinations compared with Parkinson's disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2012-10-01

    Glaucoma, Alzheimer disease and other dementia: a longitudinal analysis

    ✓ Peer-reviewed Digital health tools Ophthalmic epidemiology

    Key finding: Individuals aged 68+ years diagnosed with OAG have a decreased rate of AD or other dementia diagnosis compared to control patients without an OAG diagnosis. +2 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2012-10-01

    Deaths: preliminary data for 2011

    ✓ Peer-reviewed Disparities National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System

    Key finding: The age-adjusted death rate decreased from 747.0 deaths per 100,000 population in 2010 to 740.6 deaths per 100,000 population in 2011. +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2012-10-01

    Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice

    ✓ Peer-reviewed Drug development The Journal of neuroscience : the official journal of the Society for Neuroscience

    Key finding: Our findings suggest that GLP-1(9-36)(amide) treatment may have therapeutic potential for AD and other diseases associated with cognitive dysfunction.

    Full summary, score breakdown and related studies → Original source

  25. 2012-10-01

    Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection

    ✓ Peer-reviewed Drug development CNS drugs

    Key finding: Interestingly, GLP-1 also has very similar growth factor-like properties to insulin, and has been shown to reduce a range of degenerative processes. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →