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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 12,926–12,950 of 27,380 studies, newest first · page 518 of 1096.

April 2019 25

  1. 2019-04-15

    18F-Flortaucipir in TDP-43 associated frontotemporal dementia

    ✓ Peer-reviewed Brain scans and imaging Scientific reports

    Key finding: In C9orf72 patients, 18F-Flortaucipir binding was slightly increased in the inferior frontal lobes in the ROI based analysis, but these results were not replicated in the voxel-based analysis. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2019-04-14

    How Is End-of-Life Care With and Without Dementia Associated With Informal Caregivers' Outcomes?

    ✓ Peer-reviewed Caregiving The American journal of hospice & palliative care

    Key finding: Dementia care, both at EOL and not at EOL, was associated with the most caregiver burden relative to regular care. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2019-04-14

    Multicomponent exercise and the hallmarks of frailty: Considerations on cognitive impairment and acute hospitalization

    ✓ Peer-reviewed Prevention trials Experimental gerontology

    Key finding: Frailty syndrome encompasses several physical hallmarks such as loss of muscle strength, power output and mass, which leads to poor gait ability, fatigue, falls and overall difficulty to perform activities of daily living.

    Full summary, score breakdown and related studies → Original source

  4. 2019-04-12

    Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

    ✓ Peer-reviewed Biomarkers Molecular psychiatry

    Key finding: All fAD mutation lines demonstrated an increased Aβ42:40 ratio relative to controls, yet displayed varied signatures for Aβ43, Aβ38, and short Aβ fragments.

    Full summary, score breakdown and related studies → Original source

  5. 2019-04-11

    The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis

    ✓ Peer-reviewed Genetics Clinical epigenetics

    Key finding: Due to the small number of studies and heterogeneity in study design and outcomes, the association between DNA methylation age and age-related disease and longevity is inconclusive. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2019-04-10

    Tau Positron-Emission Tomography in Former National Football League Players

    ✓ Peer-reviewed Biomarkers The New England journal of medicine

    Key finding: A group of living former NFL players with cognitive and neuropsychiatric symptoms had higher tau levels measured by PET than controls in brain regions that are affected by CTE and did not have elevated amyloid-beta levels. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2019-04-10

    A practical computerized decision support system for predicting the severity of Alzheimer's disease of an individual

    ✓ Peer-reviewed Digital health tools Expert systems with applications

    Key finding: We demonstrated high predictive power of CFA. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2019-04-09

    White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities

    ✓ Peer-reviewed Prevention and risk Alzheimer's & dementia (New York, N. Y.)

    Key finding: Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]).

    Full summary, score breakdown and related studies → Original source

  9. 2019-04-08

    The Forgotten

    ✓ Peer-reviewed End-of-life care The American journal of hospice & palliative care

    Key finding: In this narrative, a third-year medical student recounts an experience with a patient she had while accompanying hospice and palliative workers on home visits. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2019-04-08

    APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer's disease pathophysiology

    ✓ Peer-reviewed Disease mechanisms FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    Key finding: Fecal microbiota amplicon sequencing from matched individuals with different APOE genotypes revealed no significant differences in overall microbiota diversity in group-aggregated human APOE genotypes. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2019-04-08

    Working memory revived in older adults by synchronizing rhythmic brain circuits

    ✓ Peer-reviewed Lewy body dementia Nature neuroscience

    Key finding: After 25 min of stimulation, frequency-tuned to individual brain network dynamics, we observed a preferential increase in neural synchronization patterns and the return of sender-receiver relationships of information flow within and between frontotemporal regions. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2019-04-06

    Sertraline and Mirtazapine Versus Placebo in Subgroups of Depression in Dementia: Findings From the HTA-SADD Randomized Controlled Trial

    ✓ Peer-reviewed Treatments The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    Key finding: Because of the exploratory nature of the analyses and the small sample sizes for subgroup analysis there is the need for caution in interpreting these data. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2019-04-06

    Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model

    ✓ Peer-reviewed Biomarkers Autophagy

    Key finding: We found that pharmacological activation of PPARA by the PPARA agonists gemfibrozil and Wy14643 induces autophagy in human microglia (HM) cells and U251 human glioma cells stably expressing the human APP (amyloid beta precursor protein) mutant (APP-p.M671L) and this effect is PPARA-dependent. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2019-04-05

    Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume: The Framingham Heart Study

    ✓ Peer-reviewed Long-term cohort studies JAMA network open

    Key finding: Dementia risk may be attenuated by physical activity (PA); however, the specific activity levels optimal for dementia prevention are unclear. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2019-04-05

    Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease

    ✓ Peer-reviewed Prevention and risk Journal of neuroinflammation

    Key finding: The peripheral immune system can also play a detrimental or beneficial role in CNS inflammation. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2019-04-05

    INTREPAD: A randomized trial of naproxen to slow progress of presymptomatic Alzheimer disease

    ✓ Peer-reviewed Treatments Neurology

    Key finding: In cognitively intact individuals at risk, sustained treatment with naproxen sodium 220 mg twice daily increases frequency of adverse health effects but does not reduce apparent progression of presymptomatic AD. +3 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2019-04-05

    Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients

    ✓ Peer-reviewed Biomarkers PloS one

    Key finding: Plasma neurofilament light chain (NfL) is one of the established biomarkers of AD, suggesting that it may be useful as an indicator of dementia in DS patients. +4 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2019-04-04

    Persistent and Progressive Outer Retina Thinning in Frontotemporal Degeneration

    ✓ Peer-reviewed Brain scans and imaging Frontiers in neuroscience

    Key finding: Compared to controls, returning FTD patients (143 vs. 130 μm, p = 0.005) and the tauopathy subgroup (143 vs. 128 μm, p = 0.03) had thinner outer retinas but similar inner layer thicknesses. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2019-04-04

    A Dementia Classification Framework Using Frequency and Time-Frequency Features Based on EEG Signals

    ✓ Peer-reviewed Digital health tools IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

    Key finding: The results show that: 1) the proposed method can achieve up to a 99% classification accuracy on short (4s) eyes open EEG epochs, with the KNN algorithm that has best performance when compared with alternative machine learning approaches; 2) the features extracted using the wavelet transform produced better classification performance in comparison to the features based on FFT; and 3) in the spatial domain, the temporal and parietal areas offer the best distinction between healthy controls and AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  20. 2019-04-04

    Neuro-inflammation and anti-inflammatory treatment options for Alzheimer's disease

    ✓ Peer-reviewed How common it is Clinical biochemistry

    Key finding: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory loss and dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2019-04-03

    Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer's disease: study protocol for a randomised controlled trial (ELAD study)

    ✓ Peer-reviewed Drug development Trials

    Key finding: Preclinical evidence in transgenic models of Alzheimer's disease suggests that liraglutide exerts neuroprotective effects by reducing amyloid oligomers, normalising synaptic plasticity and cerebral glucose uptake, and increasing the proliferation of neuronal progenitor cells. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2019-04-03

    Factors influencing palliative care in advanced dementia: a systematic review

    ✓ Peer-reviewed End-of-life care BMJ supportive & palliative care

    Key finding: Even though the provision of PC was empirically recognised as a care step in the management of dementia, there are barriers that hinder access of patients with dementia to appropriate facilities. +1 more finding

    Full summary, score breakdown and related studies → Original source

  23. 2019-04-03

    Machine learning based hierarchical classification of frontotemporal dementia and Alzheimer's disease

    ✓ Peer-reviewed Digital health tools NeuroImage. Clinical

    Key finding: In the present study, our automated classifier successfully classified FTD clinical subtypes with good to excellent accuracy.

    Full summary, score breakdown and related studies → Original source

  24. 2019-04-02

    Peripheral and central hearing impairment and their relationship with cognition: a review

    ✓ Peer-reviewed Risk factors International journal of audiology

    Key finding: In addition to the well-documented relationship between peripheral hearing loss and cognition highlighted in previous comprehensive reviews, there is also some evidence to suggest that there is a relationship between central hearing impairment and cognition. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2019-04-02

    GLP-1's role in neuroprotection: a systematic review

    ✓ Peer-reviewed Drug development Brain injury

    Key finding: Recent literature shows that GLP-1 and its agonists, DPP-4 inhibitors and combined GLP-1/GIP molecules are effective in partially or fully reversing the effects of neurotoxic compounds, neurovascular complications of diabetes, neuropathological changes related with Alzheimer's disease, Parkinson's disease or vascular occlusion. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →