Newest studies

Kynurenines in the CNS: from endogenous obscurity to therapeutic importance

36/100 ✓ Peer-reviewed Vascular contributions Progress in neurobiology

Key finding: In just under 20 years the kynurenine family of compounds has developed from a group of obscure metabolites of the essential amino acid tryptophan into a source of intensive research, with postulated roles for quinolinic acid in neurodegenerative disorders, most especially the AIDS-dementia complex and Huntington's disease. +3 more findings

• Treatments

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Syndromic validity of apathy in Alzheimer's disease

45/100 ✓ Peer-reviewed Vascular contributions The American journal of psychiatry

Key finding: This study provides partial validation of specific clinical criteria for apathy in Alzheimer's disease. +1 more finding

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Predictors of inadequate bowel preparation for colonoscopy

45/100 ✓ Peer-reviewed Vascular contributions The American journal of gastroenterology

Key finding: Several patient characteristics were significantly associated with colonic preparation quality independent of preparation type, compliance with preparation instructions, and procedure starting time. +3 more findings

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Behaviour in frontotemporal dementia, Alzheimer's disease and vascular dementia

36/100 ✓ Peer-reviewed Clinical safety Acta neurologica Scandinavica

Key finding: Behavioural characteristics accurately differentiate FTD from AD and CvD.

• Other Dementias

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Prospective study of hallucinations and delusions in Parkinson's disease

47/100 ✓ Peer-reviewed Clinical safety Journal of neurology, neurosurgery, and psychiatry

Key finding: Visual hallucinations are common symptoms in Parkinson's disease and are most likely of multifactorial origin. +4 more findings

• Other Dementias

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A New Rating Scale for Age-Related White Matter Changes Applicable to MRI and CT

54/100 ✓ Peer-reviewed Cognitive tests and assessment Stroke

We present a new ARWMC scale applicable to both CT and MRI that has almost equal sensitivity, except for certain regions.

• Brain Scans

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Agitation in Demented Patients in an Acute Care Hospital: Prevalence, Disruptiveness, and Staff Burden

42/100 ✓ Peer-reviewed Health systems and care delivery International Psychogeriatrics

Key finding: Ninety-five percent of the patients with dementia were reported to have at least one agitated behavior; 75% had at least one moderately disruptive behavior. +4 more findings

• Care Services

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CNS manifestations of Nasu-Hakola disease: a frontal dementia with bone cysts

47/100 ✓ Peer-reviewed Inflammation and the immune system Neurology

Key finding: Nasu-Hakola disease or polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) is a genetically heterogeneous disease characterized by a combination of systemic bone cysts and dementia. +3 more findings

• Brain Biology

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Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy

52/100 ✓ Peer-reviewed Brain tissue and pathology Annals of neurology

Key finding: We report a mutation at a novel site in APP in a three-generation Iowa family with autosomal dominant dementia beginning in the sixth or seventh decade of life. +3 more findings

• Genetics
• Brain Biology
• Caregiving

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Alpha-lipoic acid as a new treatment option for Alzheimer [corrected] type dementia

45/100 ✓ Peer-reviewed Cognitive tests and assessment Archives of gerontology and geriatrics

Key finding: Therefore, 600 mg alpha-lipoic acid was given daily to nine patients with AD and related dementias (receiving a standard treatment with acetylcholinesterase inhibitors) in an open study over an observation period of, on avarage, 337+/-80 days. +2 more findings

• Diagnosis
• Treatments

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The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement

47/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of cell biology

Key finding: Here, we report that APP and FE65 are involved in regulation of cell movement. +3 more findings

• Digital Tools

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Chemistry and biochemistry of oxidative stress in neurodegenerative disease

46/100 ✓ Peer-reviewed Lewy body dementia Current medicinal chemistry

Key finding: Although several factors appear to underlie the pathological depositions, the cause of neuronal death in each disease appears to be multifactorial. +4 more findings

• Other Dementias
• Brain Biology

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Allele varepsilon4 of apolipoprotein E gene is less frequent in Down syndrome patient of the Sicilian population and has no influence on the grade of mental retardation

36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Neuroscience letters

Key finding: Allele varepsilon4 and varepsilon3 frequencies were respectively lower (P=0.015) and higher (P=0.005) in DS patients compared to controls. +1 more finding

• Genetics
• Down Syndrome

Full summary, score breakdown and related studies → Original source

Evidence for apoptosis in the fetal Down syndrome brain

35/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of child neurology

Key finding: Various apoptosis-associated proteins (Bax, Bcl-2, Fas, p53, Hsp70, neuronal apoptosis inhibitory protein-like immunoreactivity) were investigated in four different cortical regions and the cerebellum of one fetal Down syndrome (35 weeks' gestation) postmortem brain sample compared with a control brain sample. +1 more finding

• Down Syndrome

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Brain t-complex polypeptide 1 (TCP- 1) related to its natural substrate beta1 tubulin is decreased in Alzheimer's disease

37/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Life sciences

Key finding: When t-complex polypeptide I was related to its natural and specific substrate beta 1 tubulin, the ratio was significantly decreased in the temporal, frontal, parietal cortex and in thalamus of patients with Alzheimer's disease. +1 more finding

• Brain Biology

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Development and validation of a prognostic index for 1-year mortality in older adults after hospitalization

60/100 ✓ Peer-reviewed How common it is JAMA

Key finding: Our prognostic index, which used 6 risk factors known at discharge and a simple additive point system to stratify medical patients 70 years or older according to 1-year mortality after hospitalization, had good discrimination and calibration and generalized well in an independent sample of patients at a different site. +1 more finding

• Care Services

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Clinical correlates and drug treatment of residents with stroke in long-term care

40/100 ✓ Peer-reviewed Disparities Stroke

Key finding: Stroke is highly prevalent in long-term care. +2 more findings

• Treatments
• Care Services
• Risk Factors

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Racial, ethnic, and cultural differences in the dementia caregiving experience: recent findings

45/100 ✓ Peer-reviewed Caregiving The Gerontologist

Key finding: Twenty-one studies based on 18 samples were identified. +2 more findings

• Caregiving
• Health Equity

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[Spanish language adaptation and validation of the Pfeiffer's questionnaire (SPMSQ) to detect cognitive deterioration in people over 65 years of age]

46/100 ✓ Peer-reviewed Getting a diagnosis Medicina clinica

Key finding: Mean age was 74.5 years and 65.5% of them were illiterate.

• Diagnosis

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Risk factors for Alzheimer's disease: a population-based, longitudinal study in Manitoba, Canada

59/100 ✓ Peer-reviewed Prevention and risk International journal of epidemiology

Key finding: Some well-known risk factors for AD were confirmed in this study and potential new risk factors were identified. +2 more findings

• Risk Factors
• Prevention

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Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults

60/100 ✓ Peer-reviewed Genetics JAMA

Key finding: A significant portion of sleep-disordered breathing is associated with ApoE epsilon4 in the general population. +3 more findings

• Genetics
• Lifestyle

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Deafferentation of the septo-hippocampal pathway in rats as a model of the metabolic events in Alzheimer's disease

31/100 ✓ Peer-reviewed Biomarkers International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

Key finding: Changes in the metabolic activity within the brain of patients suffering from Alzheimer's disease (AD) were investigated and compared with biochemical alterations in the hippocampus induced by fimbria/fornix transection in the rat. +4 more findings

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The reduction of NADH ubiquinone oxidoreductase 24- and 75-kDa subunits in brains of patients with Down syndrome and Alzheimer's disease

36/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Life sciences

Key finding: Complex I 24-kDa subunit was significantly reduced in occipital cortex and thalamus in patients with DS and temporal and occipital cortices in patients with AD. +2 more findings

• Down Syndrome

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Neurologists' use of ICD-9CM codes for dementia

43/100 ✓ Peer-reviewed Digital health tools Neurology

Key finding: Other codes used were not inaccurate but would result in lower reimbursement.

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Psychosis, depression and behavioural disturbances in Sydney nursing home residents: prevalence and predictors

36/100 ✓ Peer-reviewed Health systems and care delivery International journal of geriatric psychiatry

Key finding: BPSD are ubiquitous in nursing home residents. +2 more findings

• Care Services

Full summary, score breakdown and related studies → Original source