Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 11,401–11,425 of 27,380 studies, newest first · page 457 of 1096.
July 2020 25
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2020-07-22
Processes of consent in research for adults with impaired mental capacity nearing the end of life: systematic review and transparent expert consultation (MORECare_Capacity statement)
76/100 ✓ Peer-reviewed End-of-life care BMC medicine
Key finding: Studies implementing research methods (30 studies) demonstrated the role of family members as both proxy decision-makers and supporting decision-making for the person with impaired capacity. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-21
Palliative Care in Advanced Dementia
41/100 ✓ Peer-reviewed End-of-life care Frontiers in psychiatry
Key finding: Dementia syndrome is common and expected to increase significantly among older people and characterized by the loss of cognitive, psychological and physical functions. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-21
The Validation of Multifactor Model of Plasma Aβ 42 and Total-Tau in Combination With MoCA for Diagnosing Probable Alzheimer Disease
40/100 ✓ Peer-reviewed Tau biomarkers Frontiers in aging neuroscience
Key finding: The well-accepted biomarkers for clinical diagnosis of AD include β-amyloid (Aβ) deposition and pathologic tau level within cerebral spinal fluid (CSF) and imaging AD pathology such as positive emission tomography (PET) imaging of the amyloid-binding agent Pittsburgh compound B (PET-PiB). +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-20
Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot study
52/100 ✓ Peer-reviewed Disease mechanisms BMC Geriatrics
Key finding: Dementia was associated with dysbiosis characterized by differences in beta diversity and changes in taxonomic composition. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-20
Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials
76/100 ✓ Peer-reviewed Risk factors Journal of neurology, neurosurgery, and psychiatry
Key finding: Evidence-based suggestions are proposed, offering clinicians and stakeholders current guidance for the prevention of AD.
Full summary, score breakdown and related studies → Original source
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2020-07-20
Remind Me To Remember: A pilot study of a novel smartphone reminder application for older adults with dementia and mild cognitive impairment
69/100 ✓ Peer-reviewed Cognitive tests and assessment Neuropsychological rehabilitation
Key finding: Overall, caregivers and participants learned to effectively use the SmartPrompt. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-20
Cardiovascular health, genetic risk, and risk of dementia in the Framingham Heart Study
56/100 ✓ Peer-reviewed Long-term cohort studies Neurology
Key finding: We categorized CVH on the basis of the American Heart Association Ideal CVH Index and genetic risk through a genetic risk score (GRS) of common genetic variants and the APOE ε4 genotype in 1,211 Framingham Heart Study (FHS) offspring cohort participants. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-20
Serum albumin and beta-amyloid deposition in the human brain
54/100 ✓ Peer-reviewed Brain scans and imaging Neurology
Key finding: Low serum albumin may increase the risk of AD dementia by elevating amyloid accumulation. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-19
Neutrophil-lymphocyte ratio across psychiatric diagnoses: a cross-sectional study using electronic health records
46/100 ✓ Peer-reviewed Disparities BMJ open
Key finding: NLR may be useful to identify and stratify patients who could benefit from adjunctive anti-inflammatory treatment.
Full summary, score breakdown and related studies → Original source
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2020-07-18
Piloting a Dementia Caregiver Intervention in a Primary Care Setting
48/100 ✓ Peer-reviewed Caregiving Clinical gerontologist
Key finding: No significant effects were found for caregiver strain, depressive symptoms, and distress related to neuropsychiatric symptoms. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-17
The Gut Microbiome as a Component of the Gut-Brain Axis in Cognitive Health
39/100 ✓ Peer-reviewed Disease mechanisms Biological research for nursing
Key finding: Common themes in the current literature include GMB components; interactions on cognitive development; effects of GMB-gut-brain interactions on cognition, mild cognitive impairment and Alzheimer's disease; effects of GMB interactions with physiologic stress on cognition in critical care; and GMB modification for improved cognition. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-17
Peripheral TREM2 mRNA levels in early and late-onset Alzheimer disease's patients
39/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular biology reports
Key finding: Also, in elderly controls significantly higher TREM2 levels were found compared with young controls. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-17
Protein-Protein interactions uncover candidate 'core genes' within omnigenic disease networks
50/100 ✓ Peer-reviewed Genetics PLoS genetics
Key finding: Genome wide association studies (GWAS) of human diseases have generally identified many loci associated with risk with relatively small effect sizes. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-17
Deep representation learning of electronic health records to unlock patient stratification at scale
57/100 ✓ Peer-reviewed Digital health tools NPJ digital medicine
Key finding: ConvAE significantly outperformed several baselines in a clustering task to identify patients with different complex conditions, with 2.61 entropy and 0.31 purity average scores. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-17
Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial
78/100 ✓ Peer-reviewed Hippocampus size on brain scans EBioMedicine
Key finding: A 28% increase in CSF DHA and 43% increase in CSF EPA were observed in the DHA treatment arm compared to placebo (mean difference for DHA (95% CI): 0.08 µg/mL (0.05, 0.10), p<0.0001; mean difference for EPA: 0.008 µg/mL (0.004, 0.011), p<0.0001). +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-17
Designing ICTs for Users with Mild Cognitive Impairment: A Usability Study
48/100 ✓ Peer-reviewed Prevention trials International journal of environmental research and public health
Key finding: The present work contributes to the literature on ICT usability needs of users with MCI. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-17
Microglia: Agents of the CNS Pro-Inflammatory Response
51/100 ✓ Peer-reviewed TREM2 and immune genetics Cells
Key finding: Though the research of microglia spans over a century, the last two decades have increased our understanding exponentially. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-17
Preventive and Therapeutic Strategies in Alzheimer's Disease: Focus on Oxidative Stress, Redox Metals, and Ferroptosis
47/100 ✓ Peer-reviewed Mild cognitive impairment Antioxidants & redox signaling
Key finding: Alzheimer's disease (AD) is the most common cause of dementia in the elderly. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-16
The Functionality, Evidence, and Privacy Issues Around Smartphone Apps for the Top Neuropsychiatric Conditions
48/100 ✓ Peer-reviewed Cognitive tests and assessment The Journal of neuropsychiatry and clinical neurosciences
Key finding: Eighty-three apps were reviewed (stroke, N=8; migraine, N=25; Alzheimer's disease and dementia, N=8; depression, N=7; anxiety, N=14; apps targeting depression and anxiety, N=21). +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-16
Alzheimer's disease drug development pipeline: 2020
60/100 ✓ Peer-reviewed Drug development Alzheimer's & dementia (New York, N. Y.)
Key finding: The 2020 pipeline has innovations in clinical trials and treatment targets that provide hope for greater success in AD drug development programs. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-07-16
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative
72/100 ✓ Peer-reviewed Tau biomarkers Molecular psychiatry
Key finding: Despite being a multicenter study, plasma p-tau181 demonstrated high diagnostic accuracy to identify AD dementia (AUC=85.3%; 95% CI, 81.4%-89.2%), as well as to distinguish between Aβ- and Aβ+ individuals along the Alzheimer’s continuum (AUC=76.9%; 95% CI, 74.0%-79.8%). +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-16
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas
70/100 ✓ Peer-reviewed TREM2 and immune genetics Circulation research
Key finding: In a comprehensive meta-analysis, we confirm 4 known macrophage subsets-resident, inflammatory, interferon-inducible cell, and Trem2 (triggering receptor expressed on myeloid cells-2) foamy macrophages-and identify a new macrophage subset resembling cavity macrophages. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-16
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
53/100 ✓ Peer-reviewed Risk factors Molecular neurodegeneration
Key finding: There is currently no effective treatment for AD, which may be attributed in part to lack of a clear underlying mechanism. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-07-16
Multitracer model for staging cortical amyloid deposition using PET imaging
68/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: SUVr abnormality was most frequently observed in cingulate, followed by orbitofrontal, precuneal, and insular cortices and then the associative, temporal, and occipital regions.
Full summary, score breakdown and related studies → Original source
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2020-07-15
Advance care planning and decision-making in dementia care: a literature review
39/100 ✓ Peer-reviewed End-of-life care Nursing older people
Key finding: As a result, little significance may be placed on advance care planning (ACP) for people with dementia. +2 more findings
Full summary, score breakdown and related studies → Original source
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