Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,676–12,700 of 27,380 studies, newest first · page 508 of 1096.
July 2019 25
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2019-07-09
Detection of probable dementia cases in undiagnosed patients using structured and unstructured electronic health records
53/100 ✓ Peer-reviewed Digital health tools BMC medical informatics and decision making
Key finding: Dementia is underdiagnosed, and thus, ICD codes alone cannot serve as a gold standard for diagnosis. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-06
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
41/100 ✓ Peer-reviewed Risk factors International journal of molecular sciences
Key finding: The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to microbial infection and cellular damage. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-05
Efficacy and mechanism of cGAMP to suppress Alzheimer's disease by elevating TREM2
41/100 ✓ Peer-reviewed TREM2 and immune genetics Brain, behavior, and immunity
Key finding: Recently, immunotherapy is emerging as an innovative and highly conceivable strategy for AD treatment. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-05
Intersection of pathological tau and microglia at the synapse
45/100 ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica communications
Key finding: Tau pathology is strongly linked to neurodegeneration and clinical symptoms in tauopathy patients. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-05
Identifying incident dementia by applying machine learning to a very large administrative claims dataset
46/100 ✓ Peer-reviewed Digital health tools PloS one
Key finding: We hypothesized that machine-learning algorithms using administrative claims data may represent a novel approach to predicting ADRD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-05
Factors associated with frequent use of emergency-department services in a geriatric population: a systematic review
60/100 ✓ Peer-reviewed Disparities BMC geriatrics
Key finding: Further studies should bridge the gap in understanding and give a more global portrait by adding important personal variables such as dementia, organizational variables such as use of community and primary care, and contextual variables such as social and economic frailty. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-04
Effect of aerobic exercise on white matter microstructure in the aging brain
55/100 ✓ Peer-reviewed Prevention trials Behavioural brain research
Key finding: Aging is associated with decline in white matter (WM) microstructure, decreased cognitive functioning, and increased risk of Alzheimer's disease and related dementias. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-04
Mortality after osteoporotic hip fracture: incidence, trends, and associated factors
64/100 ✓ Peer-reviewed Prevention and risk Journal of orthopaedic surgery and research
Key finding: For the last 17 years, an increase of mortality for patients with hip fracture and a higher mortality rate in men than in women were observed. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-03
Association of Hearing Loss With Dementia
74/100 ✓ Peer-reviewed Risk factors JAMA network open
Key finding: In this study, hearing loss was positively associated with a risk of dementia, especially in patients aged 45 to 64 years. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-03
Development and Validation of a Deep Learning Algorithm for Mortality Prediction in Selecting Patients With Dementia for Earlier Palliative Care Interventions
71/100 ✓ Peer-reviewed Clinical safety JAMA network open
Key finding: A deep learning algorithm based on patient demographic information and longitudinal clinical notes appeared to show promising results in predicting mortality among patients with dementia in different time frames. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-03
Association of Altered Liver Enzymes With Alzheimer Disease Diagnosis, Cognition, Neuroimaging Measures, and Cerebrospinal Fluid Biomarkers
69/100 ✓ Peer-reviewed Tau biomarkers JAMA network open
Key finding: Increasing evidence suggests an important role of liver function in the pathophysiology of Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-02
Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer's Disease
43/100 ✓ Peer-reviewed Tau biomarkers Neuro-degenerative diseases
Key finding: CSF-NEP was significantly inversely associated with CSF-Aβ42 and positively with the extent of neuronal injury as measured by CSF-tau and FDG-PET. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-02
TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment
44/100 ✓ Peer-reviewed TREM2 and immune genetics Glia
Key finding: However, it remains unknown how this receptor functions on microglia to modulate these diverse neuropathologies. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-02
Cognitive reserve and clinical progression in Alzheimer disease: A paradoxical relationship
71/100 ✓ Peer-reviewed Mild cognitive impairment Neurology
Key finding: Among Aβ-positive individuals, greater CR related to attenuated clinical progression in predementia stages of AD, but accelerated cognitive decline after the onset of dementia. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-07-02
The global prevalence of erectile dysfunction: a review
51/100 ✓ Peer-reviewed Caregiving BJU international
Key finding: ED screening tools in population-based studies are a major source of discrepancy. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-07-02
Effects of physical activity and exercise on the cognitive function of patients with Alzheimer disease: a meta-analysis
68/100 ✓ Peer-reviewed Caregiving BMC geriatrics
Key finding: As one of few meta-analyses comparing different quantities of physical activity and exercise interventions for AD in details, our study suggests that physical activity and exercise can improve cognition of older adults with AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07 month only
The Real-World Medicare Costs of Alzheimer Disease: Considerations for Policy and Care
39/100 ✓ Peer-reviewed Costs and economics Journal of managed care & specialty pharmacy
Key finding: This study found that 40% of deceased beneficiaries have Alzheimer disease or unspecified dementia diagnoses in their claims history. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07 month only
[Use AI for Dementia Diagnosis]
39/100 ✓ Peer-reviewed Brain scans and imaging Brain and nerve = Shinkei kenkyu no shinpo
Key finding: Using AI for dementia diagnosis is still in research stage, however some of the work points to the development of new medical devices. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
The proteostasis network and its decline in ageing
38/100 ✓ Peer-reviewed Disease mechanisms Nature reviews. Molecular cell biology
Key finding: The possibilities of pharmacological augmentation of the capacity of proteostasis networks hold great promise for delaying the onset of age-related pathologies associated with proteome deterioration and for extending healthspan.
Full summary, score breakdown and related studies → Original source
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2019-07-01
Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel
38/100 ✓ Peer-reviewed Brain tissue and pathology Journal of the American College of Cardiology
Key finding: Cognitive impairment associated with aging has emerged as one of the major public health challenges of our time.
Full summary, score breakdown and related studies → Original source
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2019-07-01
Antisense Oligonucleotide Therapies for Neurodegenerative Diseases
38/100 ✓ Peer-reviewed Drug development Annual review of neuroscience
Key finding: Antisense drugs are currently in development for the treatment of amyotrophic lateral sclerosis, Huntington's disease, and Alzheimer's disease, and multiple research programs are underway for additional neurodegenerative diseases. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
Discovery and preclinical characterization of [ 18 F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies
41/100 ✓ Peer-reviewed Brain scans and imaging European journal of nuclear medicine and molecular imaging
Key finding: [ 18 F]PI-2620 was selected for clinical validation. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
Long Non-coding RNA BACE1-AS May Serve as an Alzheimer's Disease Blood-Based Biomarker
45/100 ✓ Peer-reviewed Biomarkers Journal of molecular neuroscience : MN
Key finding: Circulating long noncoding RNAs (lncRNAs) might serve as biomarkers for different pathological conditions. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
Risk of dementia in stroke-free patients diagnosed with atrial fibrillation: data from a population-based cohort
67/100 ✓ Peer-reviewed Vascular contributions European heart journal
Key finding: Incident AF was associated with an increased risk of dementia, independent of clinical stroke in an elderly population. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-07-01
Age-related Hearing Loss and Dementia
45/100 ✓ Peer-reviewed Prevention and risk Alzheimer disease and associated disorders
Key finding: Dementia is a devastating disease and global health challenge that is highly prevalent worldwide. +4 more findings
Full summary, score breakdown and related studies → Original source
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