Newest studies

OCTA: Essential or Gimmick?

43/100 ✓ Peer-reviewed Brain scans and imaging Ophthalmology and therapy

Key finding: In cases of retinal vein occlusions, OCTA can reveal specific microvascular features and allow for depth-resolved measurements of the foveal avascular zone, providing significant prognostic implications. +1 more finding

Full summary, score breakdown and related studies → Original source

CSF proteomic profiles of neurodegeneration biomarkers in Alzheimer's disease

46/100 ✓ Peer-reviewed Tau biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: A+T+Ng+ and A+T+NfL+ showed different proteomic profiles compared to A+T+Ng- and A+T+NfL-, respectively. +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Racial/ethnic differences in neuropsychiatric disturbances associated with incident dementia

63/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: NPS were present in 95% in at least one time point. +3 more findings

• Health Equity

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Effects of a multidomain intervention against cognitive decline on dementia risk profiles - Results from the AgeWell.de trial

83/100 ✓ Peer-reviewed Prevention trials Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: The AgeWell.de intervention reduced dementia risk.

• Risk Factors
• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Medical costs of Swedish nursing home residents at the end of life: a retrospective observational registry study

38/100 ✓ Peer-reviewed Health systems and care delivery BMC geriatrics

Key finding: According to the adjusted (multivariable) models for the 38,805 studied nursing home decedents, when studying the actual period of stay in nursing homes, we found significantly greater medical costs associated with male sex (RR 1.29 (1.25-1.33), p < 0.0001) and younger age (65-79 years vs. ≥90 years: RR 1.92 (1.85-2.01), p < 0.0001). +3 more findings

• Care Services
• Policy
• End-of-Life Care

Full summary, score breakdown and related studies → Original source

APP antisense oligonucleotides reduce amyloid-β aggregation and rescue endolysosomal dysfunction in Alzheimer's disease

52/100 ✓ Peer-reviewed Genetics Brain

Key finding: APP gene dosage is strongly associated with Alzheimer's disease (AD) pathogenesis. +2 more findings

• Genetics
• Digital Tools

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Associations of ambient air pollution exposure and lifestyle factors with incident dementia in the elderly: A prospective study in the UK Biobank

46/100 ✓ Peer-reviewed Risk factors Environment international

Key finding: During a 12-year period of follow-up, 4,389 incidents of all-cause dementia were identified. +4 more findings

• Risk Factors
• Lifestyle

Full summary, score breakdown and related studies → Original source

Florbetaben amyloid PET acquisition time: Influence on Centiloids and interpretation

55/100 ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

Key finding: CL values increased significantly over the scan using the whole cerebellum, cerebellar gray matter, and brainstem as reference regions, particularly in amyloid-positive individuals. +4 more findings

• Brain Scans

Full summary, score breakdown and related studies → Original source

Unexpected Low Rate of Amyloid-β Pathology in Multiple Sclerosis Patients

46/100 ✓ Peer-reviewed Biomarkers Annals of neurology

Key finding: These results support that MS is associated with reduced Alzheimer disease risk, and suggest new avenues of research.

• Biomarkers

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AI-based differential diagnosis of dementia etiologies on multimodal data

71/100 ✓ Peer-reviewed Digital health tools Nature medicine

Key finding: Our model demonstrated proficiency in addressing mixed dementia cases, with a mean AUROC of 0.78 for two co-occurring pathologies.

• Digital Tools
• Diagnosis

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Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice

43/100 ✓ Peer-reviewed Drug development Science translational medicine

Key finding: We found that intranasally administered TTCM2-ms efficiently entered the brain in hTau-tauopathy mice, targeting pathological tau in intracellular compartments. +1 more finding

• Brain Biology

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Neuroimaging biomarkers and CSF sTREM2 levels in Alzheimer's disease: a longitudinal study

70/100 ✓ Peer-reviewed TREM2 and immune genetics Scientific reports

Key finding: Based on our analysis there was a significant difference in baseline and rate of change of CSF sTREM2 between ATN groups. +4 more findings

• Biomarkers
• Genetics
• Brain Scans

Full summary, score breakdown and related studies → Original source

Changes in Alzheimer's disease blood biomarkers in kidney failure before and after kidney transplant

46/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)

Key finding: CKD patients showed elevated levels of neurofilament light (117 ± 72 vs. 11 ± 5 pg/mL), phosphorylated tau 181 (75 ± 42 vs. 13 ± 8 pg/mL), glial fibrillary acidic protein (193 ± 127 vs. 94 ± 39 pg/mL), amyloid β 42 (17 ± 5 vs. 5 ± 1 pg/mL), and amyloid β 40 (259 ± 96 vs. 72 ± 17 pg/mL) compared to controls. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Medicare Payments and ACOs for Dementia Patients Across Race and Social Vulnerability

71/100 ✓ Peer-reviewed Disparities The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Key finding: Among those newly diagnosed, Black and Hispanic patients encountered higher total costs compared to White patients, and ADRD patients living in the most vulnerable areas experienced the highest total costs compared to patients living in other regions. +4 more findings

• Health Equity
• Policy

Full summary, score breakdown and related studies → Original source

Air pollution exposure and mortality from neurodegenerative diseases in the Netherlands: A population-based cohort study

46/100 ✓ Peer-reviewed Risk factors Environmental research

Key finding: We had a follow-up of 71 million person-years. +4 more findings

• Risk Factors

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Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals

63/100 ✓ Peer-reviewed Biomarkers Nature communications

Key finding: Compared to white individuals, Black individuals had higher average plasma Aβ42/40 levels at baseline, consistent with a lower average level of amyloid pathology. +1 more finding

• Biomarkers

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FDA Approves Treatment for Adults with Alzheimer's Disease (Kisunla / donanemab-azbt)

15/100 ⚠ Regulatory decision — not a study Treatments U.S. Food and Drug Administration

Key finding: Trial enrolled 1,736 participants; donanemab group showed statistically significant reduction in clinical decline vs placebo on multiple cognitive/functional scales at Week 76 +2 more findings

• Treatments

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Analysis of eligibility criteria in Alzheimer's and related dementias clinical trials

43/100 ✓ Peer-reviewed Disparities Scientific reports

Key finding: Eligibility criteria were coded into the following categories: Medical, Neurologic, Psychiatric, and Procedural. +4 more findings

• Clinical Trials
• Health Equity

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Deep Learning Analysis of Retinal Structures and Risk Factors of Alzheimer's Disease

43/100 ✓ Peer-reviewed Brain scans and imaging Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Key finding: Our result shows that the model not only can predict several risk factors above the baseline but also can discover the relationship between the retinal structures and risk factors to provide insights into the retinal imaging biomarkers of Alzheimer's disease.

• Risk Factors
• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

The Black Book of Psychotropic Dosing and Monitoring

50/100 ✓ Peer-reviewed Treatments Psychopharmacology bulletin

Key finding: The phase III program for Auvelity, showed that the drug was well tolerated with the most common side effects being dizziness, headache, and dry mouth. 86 Another novel antidepressant agent approved in 2023 is zuranolone (Zurzuvae). +4 more findings

• Treatments
• Clinical Trials

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Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative diseases

72/100 ✓ Peer-reviewed Disease mechanisms Brain : a journal of neurology

Key finding: SNAP-25 and 14-3-3 zeta/delta also had the strongest associations with tau-PET, amyloid-β-PET and cortical thickness at baseline and were associated with longitudinal changes in these imaging biomarkers [β(standard error, SE) = -0.056(0.0006) to 0.058(0.005), P < 0.0001]. +2 more findings

• Biomarkers
• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

A phase 2, open-label study of anti-inflammatory NE3107 in patients with dementias

56/100 ✓ Peer-reviewed Inflammation and the immune system Medicine

Key finding: NE3107 was associated with clinician-rated improvements in cerebral blood flow and functional connectivity within the brain. +2 more findings

• Clinical Trials
• Brain Biology
• Diagnosis

Full summary, score breakdown and related studies → Original source

Association of neighborhood disadvantage with cognitive function and cortical disorganization in an unimpaired cohort

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors ArXiv

Key finding: Neighborhood disadvantage is associated with worse health and cognitive outcomes. +1 more finding

• Health Equity

Scored 38 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Adult-onset deactivation of autophagy leads to loss of synapse homeostasis and cognitive impairment, with implications for alzheimer disease

46/100 ✓ Peer-reviewed Biomarkers Autophagy

Key finding: Isolated forebrain synaptosomes, rather than total homogenates, from atg7 iKO mice demonstrated accumulation of synaptic proteins, suggesting that the synapse might be a vulnerable site for protein homeostasis disruption. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Clinical Outcomes and Cost-Effectiveness of Collaborative Dementia Care: A Secondary Analysis of a Cluster Randomized Clinical Trial

71/100 ✓ Peer-reviewed Costs and economics JAMA Network Open

Key finding: Participants receiving CDCM showed significantly fewer behavioral and psychological symptoms (adjusted mean difference [AMD] in NPI score, -10.26 [95% CI, -16.95 to -3.58]; P = .003; Cohen d, -0.78 [95% CI, -1.09 to -0.46]), better mental health (AMD in SF-12 Mental Component Summary score, 2.26 [95% CI, 0.31-4.21]; P = .02; Cohen d, 0.26 [95% CI, -0.11 to 0.51]), and lower caregiver burden (AMD in BIZA-D score, -0.59 [95% CI, -0.81 to -0.37]; P Conclusions and relevance In this secondary analysis of a cluster randomized clinical trial, CDCM was associated with improved patient, caregiver, and health system-relevant outcomes over 36 months beyond the intervention period. +2 more findings

• Clinical Trials
• Policy

Full summary, score breakdown and related studies → Original source