Newest studies

Reduced phosphatases and hyperphosphorylated glutamatergic receptors persist from early to late stages of prion disease

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

Key finding: Together, these findings suggest that early phosphatase reduction accompanies neuronal hyperactivity, and precedes substantial inflammation. +1 more finding

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Selective vulnerability: validation of atypical neurodegenerative disease variants in histopathological reference cohorts

16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology Research Square

Key finding: Conventional, cohort-based staging exhibited profound topographical inversion, yielding negative correlations for TDP-43 ( ρ = -0.9113, p < 0.001) and α-synuclein ( ρ = -0.8660, p = 0.003) sub-cohorts. +4 more findings

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Systematic identification of perioperative neurocognitive disorder related biomarkers in Alzheimer’s disease and development of machine learning-based diagnostic models

16/100 ⚠ Preprint — not yet peer-reviewed Brain tissue and pathology Research Square

Key finding: Accumulating evidence suggests that perioperative neurocognitive disorder (PND) shares several pathological characteristics with AD; however, the molecular crosstalk between these two disorders and relevant biomarkers remain largely unexplored. +4 more findings

• Brain Biology
• Treatments
• Diagnosis

Scored 24 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Depth-Dependent Alterations in Cerebral Blood and Tissue Oxygenation Associated with Tau in Alzheimer’s Disease Models

16/100 ⚠ Preprint — not yet peer-reviewed Vascular contributions bioRxiv

Key finding: In 6-month-old rTg4510 mice, tissue pO2 trended lower than in WT mice, and the fraction of low pO2 values (< 18 mmHg) increased with depth, reaching 33% at 200 µm versus 4% in WT. +4 more findings

• Brain Biology

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Insulin fails to mitigate amyloid pathology but modulates intestinal morphology in the 5xFAD model revealed by synchrotron-based XPCT

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms bioRxiv

Key finding: Micro-XPCT visualized plaque-like deposits, nanoXPCT revealed their heterogeneous internal organization, and MOAB-2 labeling provided qualitative support for amyloid pathology. +3 more findings

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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The Role of Cortisol in CNS Disease –11β-HSD1 Inhibition as a Potential New Therapeutic Strategy for Alzheimer’s Disease and Major Depressive Disorder

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Preprints.org

Key finding: An extensive preclinical and clinical literature suggests that chronically, excess cortisol is detrimental. +3 more findings

• Treatments

Scored 29 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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“The conversation wouldn’t happen without us”: How interpreter involvement affects dementia service delivery for CALD clients in Australia

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Research Square

Key finding: Participants perceived that interpreter involvement could support communication, direct participation, and the interpretability of assessments when it was timely, appropriately prepared, and aligned with clinical roles.

Scored 34 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Progressive neurodegeneration of the locus coeruleus drives rapid eye movement sleep fragmentation

16/100 ⚠ Preprint — not yet peer-reviewed Brain scans and imaging bioRxiv

Key finding: Although LC degeneration and sleep disruption progress in parallel, whether LC degeneration causally contributes to sleep abnormalities, and which sleep changes are associated with this process, remain unresolved. +4 more findings

• Brain Biology
• Lifestyle

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Electroacupuncture alleviate cognitive impairment via activation of TREM2-positive microglia in APP/PS1 mice

16/100 ⚠ Preprint — not yet peer-reviewed TREM2 and immune genetics Research Square

Key finding: EA ameliorated cognitive impairment in APP/PS1 mice by enhancing TREM2⁺ microglia-mediated Aβ clearance and suppressing neuroinflammation. scRNA-seq further revealed that EA reshaped microglial transcriptional states and intercellular communication networks in a TREM2-dependent manner. +2 more findings

• Brain Biology
• Genetics
• Digital Tools

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Comparative analysis of plasma pTau217, NfL and eight modifiable risk scores for 11-year dementia prediction in the HUNT Study

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

Key finding: Higher pTau217 was associated with greater likelihood of developing dementia 11 years later. +4 more findings

• Biomarkers

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Midlife and Late-Life Alzheimer Disease Blood Biomarkers and 11-Year Cognitive Decline

74/100 ✓ Peer-reviewed Tau biomarkers Neurology

Key finding: Midlife p-tau181 was associated with faster 11-year memory decline beginning 20 years later in the ARIC cohort, which underscores a potentially long prodromal phase of cognitive decline that could precede dementia onset. +4 more findings

• Biomarkers

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Selective vulnerability of human basal forebrain subsystems in ageing and neuropsychiatric disorders

16/100 ⚠ Preprint — not yet peer-reviewed How common it is medRxiv

Key finding: These findings identify an anatomically specific age-related profile of the human BF, with structural vulnerability manifest and pre-diagnostic neurological disorders, which is not substantially explained by common inherited risk. +1 more finding

Scored 31 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Neuro-JEPA: Building and Evaluating Health-System Scale Neuroimaging Foundation Models with Mixture of Experts

16/100 ⚠ Preprint — not yet peer-reviewed Mild cognitive impairment Research Square

Key finding: Across these evaluations, Neuro-JEPA achieved the strongest overall performance and generalized robustly across heterogeneous cohorts, outperforming existing neuroimaging foundation models and strong conventional baselines in the majority of comparisons despite using less than one-third of the pretraining data of leading models. +1 more finding

• Brain Scans

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Constraint Based Metabolic Modeling Identifies Robust Biomarkers and Therapeutic Target Combinations in Alzheimer Disease

16/100 ⚠ Preprint — not yet peer-reviewed Prevention and risk Research Square

Key finding: These findings provide testable hypotheses for metabolic biomarkers and combination interventions in Alzheimer’s disease.

• Biomarkers

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Beyond Usual Pace: Quick Walking Speed and Brain Health Outcomes in the Framingham Heart Study

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors medRxiv

Key finding: We estimated associations per SD slower walking or smaller adaptability using linear, logistic, and Cox regression (10-year follow-up), overall and in women and men. +4 more findings

• Risk Factors
• Lifestyle

Scored 45 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Research attitudes mediate the association between educational attainment and willingness to participate in Alzheimer’s disease research beyond Alzheimer’s disease knowledge

16/100 ⚠ Preprint — not yet peer-reviewed Prevention trials medRxiv

Key finding: STRUCTURED ABSTRACT INTRODUCTION This study examined the extent to which educational attainment, Alzheimer’s disease (AD) knowledge, and research attitudes are associated with willingness to participate in AD research, and whether AD knowledge and research attitudes mediate associations between educational attainment and willingness to participate. +1 more finding

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Alzheimer’s disease blood-based biomarkers in the Boston Latino Aging Study (BLAST): Associations with cognition and depressive symptoms

16/100 ⚠ Preprint — not yet peer-reviewed Biomarkers medRxiv

Key finding: Distinct biomarker associations with cognitive and emotional functioning support further longitudinal evaluation of BBMs for risk characterization in Latino older adults and potential disease monitoring applications. +2 more findings

• Biomarkers
• Health Equity

Scored 44 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Predictors of Antiamyloid Medication Utilization and Adherence Among People With Alzheimer Disease and Mild Cognitive Impairment

62/100 ✓ Peer-reviewed Drug development Neurology

Key finding: We determined the demographics and social drivers of health associated with utilization and initial adherence of these medications. +4 more findings

• Treatments
• Early Stage
• Health Equity

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Limbic Vulnerability Characterises REM Sleep Behaviour Disorder Across Prodromal and Established Lewy Body Disease

16/100 ⚠ Preprint — not yet peer-reviewed Mild cognitive impairment Research Square

Key finding: Greater limbic vulnerability was associated with RBD symptom burden, reduced dopamine transporter binding and cognitive impairment. +1 more finding

• Early Stage
• Other Dementias
• Lifestyle

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Individual Angiotensin Receptor Blockers and Risk of Dementia: A Target Trial Emulation Study

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools medRxiv

Key finding: Of 22,025,599 individuals screened, 2,051,275 were eligible; matched cohorts ranged from 10,113 to 857,773, with median follow-up of 4.7 to 7.2 years. +4 more findings

• Clinical Trials
• Risk Factors

Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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PaliGemX: An Interpretable Multimodal Transformer for Early Alzheimer’s Detection

16/100 ⚠ Preprint — not yet peer-reviewed Digital health tools Research Square

Key finding: This study presents a multi-modal vision transformer architecture that integrates co-attention techniques and Pali Gamma, which achieves best performance in Alzheimer’s diseasePali Gemma can be applied to aid more informed clinical decision-making and improve the results of patients with Alzheimer disease in terms of diagnosing and treating the disease through continuous fusion of visual and text inputs.

• Digital Tools

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Family physicians' attitudes toward people with dementia and their association with empathy

16/100 ⚠ Preprint — not yet peer-reviewed Health systems and care delivery Research Square

Key finding: Family physicians' empathy levels were independently associated with general, supportive, and accepting attitudes toward people with dementia, but not with exclusionary attitudes. +4 more findings

• Caregiving

Scored 35 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Cultural and linguistic adaptation of a personalised post-diagnostic dementia intervention for Bangladeshi families in the UK: an iterative adaptation study

16/100 ⚠ Preprint — not yet peer-reviewed Caregiving medRxiv

Key finding: Evidence suggests that evidence-based psychosocial dementia interventions can be successfully adapted for different cultural contexts, but further evidence is needed on how adaptations are developed and refined in practice.

• Caregiving
• Diagnosis

Scored 27 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Integrative Multiomics Analysis Reveals a Coordinated Molecular Signature of Neuroresilience in human MAPT-knockout hiPSC-derived Neurons with relevance for Alzheimer’s and Neurodegenerative Disease

16/100 ⚠ Preprint — not yet peer-reviewed Disease mechanisms Research Square

Key finding: These findings demonstrate that Tau deletion induces an active, multilevel gain-of-resilience rather than passive resistance. +3 more findings

• Brain Biology

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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Caregiving experiences of older-adult informal family caregivers for older adults with comorbid dementia and physical disability: A qualitative study using the caregiving stress-process model

16/100 ⚠ Preprint — not yet peer-reviewed Risk factors Research Square

Key finding: Five core themes and fifteen corresponding sub-themes were extracted from interview transcripts: (1) Structural caregiving context, including family structural constraints, the influence of filial piety culture, and insufficient aged-care supply; (2) Multiple caregiving stressors, covering primary care burden, independent care decision-making pressure, restricted social engagement, and intra-family conflicts; (3) Limited buffering support resources, involving inadequate formal care services, insufficient informal assistance from relatives, and individual psychological coping strategies; (4) Negative caregiving experiences, including persistent physical exhaustion and sustained emotional depletion; (5) Dual perceptions of caregiving outcomes, consisting of emotional gains from kinship bonding, resistance to institutional care, and long-term anxiety about future care arrangements.

• Caregiving

Scored 21 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

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