Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 18,901–18,925 of 27,380 studies, newest first · page 757 of 1096.
February 2013 9
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2013-02-01
SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy
46/100 ✓ Peer-reviewed Tau biomarkers JAMA neurology
Key finding: Therapies designed to decrease the level of SOD1 are currently in a clinical trial for patients with superoxide dismutase (SOD1)-linked familial amyotrophic lateral sclerosis (ALS). +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-01
Review: systemic inflammation and Alzheimer's disease
46/100 ✓ Peer-reviewed Mild cognitive impairment Neuropathology and applied neurobiology
Key finding: The role of systemic inflammation, and indeed inflammation in general, is still largely considered to be as a contributor to the disease process rather than of aetiological importance although there is emerging evidence to suggest that its role may predate the deposition of amyloid.
Full summary, score breakdown and related studies → Original source
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2013-02-01
Parkinson disease: an update
33/100 ✓ Peer-reviewed Digital health tools American family physician
Key finding: Although these conditions are associated with significantly lower quality of life, they may improve with treatment.
Full summary, score breakdown and related studies → Original source
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2013-02-01
Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers
58/100 ✓ Peer-reviewed Disparities British journal of clinical pharmacology
Key finding: The results indicate that short term use of this piperine-enhanced curcuminoid preparation is unlikely to result in a clinically significant interaction involving CYP3A, CYP2C9 or the paracetamol conjugation enzymes. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-01
Development of DEMQOL-U and DEMQOL-PROXY-U: generation of preference-based indices from DEMQOL and DEMQOL-PROXY for use in economic evaluation
16/100 ⚠ Report — not peer-reviewed Disparities Health technology assessment (Winchester, England)
Key finding: The results presented are sufficiently encouraging to recommend that the DEMQOL instruments be used alongside a generic measure such as the European Quality of Life-5 Dimensions (EQ-5D) in future studies of interventions in dementia as there was evidence that they can be more sensitive for patients at the milder end of disease and some limited evidence that the person with dementia measure may be able to reflect deterioration. +1 more finding
Scored 39 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2013-02-01
Relevance of magnetic resonance imaging for early detection and diagnosis of Alzheimer disease
48/100 ✓ Peer-reviewed Brain scans and imaging The Medical clinics of North America
Key finding: There is no evidence for individual risk prediction and even less for specific treatments. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-01
Change in end-of-life care for Medicare beneficiaries: site of death, place of care, and health care transitions in 2000, 2005, and 2009
76/100 ✓ Peer-reviewed Getting a diagnosis JAMA
Key finding: Our random 20% sample included 848,303 fee-for-service Medicare decedents (mean age, 82.3 years; 57.9% female, 88.1% white). +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-02-01
The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study
59/100 ✓ Peer-reviewed Prevention and risk Annals of internal medicine
Key finding: Higher midlife fitness levels seem to be associated with lower hazards of developing all-cause dementia later in life. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-02-01
APOE ε4 increases risk for dementia in pure synucleinopathies
69/100 ✓ Peer-reviewed Genetics JAMA neurology
Key finding: The APOE ϵ4 allele is a strong risk factor across the LBD spectrum and occurs at an increased frequency in pDLB relative to PDD. +3 more findings
Full summary, score breakdown and related studies → Original source
January 2013 16
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2013-01-30
Improving dementia care: the role of screening and detection of cognitive impairment
40/100 ✓ Peer-reviewed Costs and economics Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Recent research on causes of and treatments for cognitive impairment has converged to challenge previous thinking about screening for cognitive impairment. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-30
Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
40/100 ✓ Peer-reviewed Disease mechanisms Frontiers in cellular neuroscience
Key finding: Overall, phagocytosis is considered a beneficial phenomenon, since it eliminates dead cells and induces an anti-inflammatory response. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-30
Long-term adherence to the Mediterranean diet is associated with overall cognitive status, but not cognitive decline, in women
52/100 ✓ Peer-reviewed Prevention trials The Journal of nutrition
Key finding: In primary analyses of cognitive change, the MeDi was not associated with decline in global cognition or verbal memory. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-30
AD dementia risk in late MCI, in early MCI, and in subjective memory impairment
66/100 ✓ Peer-reviewed How common it is Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: SMI and EMCI with self-reported concerns were associated with the same risk of AD dementia, suggesting that pre-LMCI risk conditions should be extended to SMI with concerns. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-30
Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging
63/100 ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The data are consistent with expected rates of amyloid positivity among individuals with clinical diagnoses of AD and MCI, and indicate the potential value of florbetapir F18 PET as an adjunct to clinical diagnosis. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-30
Mental exercises for cognitive function: clinical evidence
55/100 ✓ Peer-reviewed Treatments Journal of preventive medicine and public health = Yebang Uihakhoe chi
Key finding: The results of our investigations indicate that our cognitive intervention using reading and arithmetic problems demonstrated a transfer effect and they provide convincing evidence that cognitive training maintains and improves the cognitive functions of dementia patients and healthy seniors.
Full summary, score breakdown and related studies → Original source
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2013-01-29
The promise of N-acetylcysteine in neuropsychiatry
36/100 ✓ Peer-reviewed Prevention and risk Trends in pharmacological sciences
Key finding: N-Acetylcysteine (NAC) targets a diverse array of factors germane to the pathophysiology of multiple neuropsychiatric disorders including glutamatergic transmission, the antioxidant glutathione, neurotrophins, apoptosis, mitochondrial function, and inflammatory pathways. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-29
Default mode network connectivity indicates episodic memory capacity in mesial temporal lobe epilepsy
43/100 ✓ Peer-reviewed Hippocampus size on brain scans Epilepsia
Key finding: Our results demonstrate the striking clinical significance of the brain's intrinsic connectivity in evaluating cognitive capacity and indicating the potential of postsurgical cognitive morbidity in patients with mTLE. +2 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-29
Chronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease
40/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Free radical biology & medicine
Key finding: In contrast, prolonged elevation of RCAN1-1L levels is associated with the types of neurodegeneration observed in several diseases, including Alzheimer disease and Down syndrome. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-28
Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease
47/100 ✓ Peer-reviewed Brain scans and imaging Brain : a journal of neurology
Key finding: In contrast, all Alzheimer's disease variants showed diffuse patterns of (11)C-labelled Pittsburgh compound B binding, with posterior cortical atrophy additionally showing elevated uptake in occipital cortex compared with early-onset Alzheimer's disease. +3 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-28
An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo
40/100 ✓ Peer-reviewed Disease mechanisms The Journal of biological chemistry
Key finding: Considerable evidence suggests that soluble Aβ oligomers are responsible for the synaptic dysfunction and cognitive deficit observed in AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-28
Criteria for the diagnosis of corticobasal degeneration
61/100 ✓ Peer-reviewed Getting a diagnosis Neurology
Current criteria for the clinical diagnosis of pathologically confirmed corticobasal degeneration (CBD) no longer reflect the expanding understanding of this disease and its clinicopathologic correlations.
Full summary, score breakdown and related studies → Original source
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2013-01-26
New findings concerning vertebrate porin II--on the relevance of glycine motifs of type-1 VDAC
29/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Molecular genetics and metabolism
Key finding: Recent data have allowed speculating that amyloid Aβ induces apoptosis via opening type-1 VDAC in cell membranes of hypo-metabolic neurons, a process most likely running over life time--as leaves fall from trees in the tropics--and ending in Alzheimer's disease whenever critical brain regions are affected. +4 more findings
Full summary, score breakdown and related studies → Original source
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2013-01-25
Alcohol-related dementia: an update of the evidence
48/100 ✓ Peer-reviewed Prevention and risk Alzheimer's research & therapy
Key finding: Neuropathological and imaging studies suggest that excessive and prolonged use of alcohol may lead to structural and functional damage that is permanent in nature; however, there is debate about the relative contributions of the direct toxic effect of alcohol (neurotoxicity hypothesis), and the impact of thiamine deficiency, to lasting damage. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-24
Pattern of regional cortical thinning associated with cognitive deterioration in Parkinson's disease
51/100 ✓ Peer-reviewed Mild cognitive impairment PloS one
Key finding: The pattern of regional decreased cortical thickness that relates to cognitive deterioration is present in PD-MCI patients, involving areas that play a central role in the storage of prior experiences, integration of external perceptions, and semantic processing. +1 more finding
Full summary, score breakdown and related studies → Original source
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2013-01-23
Assessment and diagnosis of dementia in Hispanic and non-Hispanic white outpatients
46/100 ✓ Peer-reviewed Disparities The Gerontologist
Key finding: When using ethnic group-specific norms, NP and functional abilities predicted diagnosis in both groups with no significant differences but BPS was only significant in Hispanics. +4 more findings
Full summary, score breakdown and related studies → Original source
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