Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 12,526–12,550 of 27,380 studies, newest first · page 502 of 1096.
August 2019 25
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2019-08-30
Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents
41/100 ✓ Peer-reviewed Treatments PLoS pathogens
Key finding: Curli amyloid fibrils secreted by Enterobacteriaceae mediate host cell adhesion and contribute to biofilm formation, thereby promoting bacterial resistance to environmental stressors. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-30
Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases
41/100 ✓ Peer-reviewed Genetics Frontiers in immunology
Key finding: Human monocytes are divided in three major populations; classical (CD14 + CD16 - ), non-classical (CD14 dim CD16 + ), and intermediate (CD14 + CD16 + ). +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-30
Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment
55/100 ✓ Peer-reviewed Biomarkers EBioMedicine
Key finding: At baseline, subjects with normal vs. impaired cognition show no notable difference in microbiome diversity but several unique microbial signatures are detected in subjects with mild cognitive impairment. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-30
Current State of Digital Biomarker Technologies for Real-Life, Home-Based Monitoring of Cognitive Function for Mild Cognitive Impairment to Mild Alzheimer Disease and Implications for Clinical Care: Systematic Review
67/100 ✓ Peer-reviewed Digital health tools Journal of medical Internet research
Key finding: Despite the promise of a multitude of sensors and devices that can be applied, there are no agreed-upon standards for digital biomarkers, nor are there comprehensive evidence-based results for which digital biomarkers may be demonstrated to be most effective. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-30
Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities
52/100 ✓ Peer-reviewed Genetics Frontiers in aging neuroscience
Key finding: In this review, we are presenting a state-of-knowledge report intended to highlight the variety of microglial functions and pathways shown to be critically involved in AD progression. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-29
When time's arrow doesn't bend: APOE-ε4 influences episodic memory before old age
39/100 ✓ Peer-reviewed Genetics Neuropsychologia
Key finding: These results suggest specific and dynamic alterations to episodic memory as a function of APOE allelic variation and age.
Full summary, score breakdown and related studies → Original source
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2019-08-29
Associations between cerebrovascular risk factors and parkinson disease
60/100 ✓ Peer-reviewed Digital health tools Annals of neurology
Key finding: Cerebrovascular risk factors are associated with Parkinson disease, an effect comparable to their association with Alzheimer disease. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-28
Agreement of amyloid PET and CSF biomarkers for Alzheimer's disease on Lumipulse
50/100 ✓ Peer-reviewed Brain scans and imaging Annals of clinical and translational neurology
Key finding: Aβ1-42, tTau and pTau (but not Aβ1-40) and the ratios with Aβ1-42 had good diagnostic agreement with 18 F-Florbetapir PET. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-28
Robust automated computational approach for classifying frontotemporal neurodegeneration: Multimodal/multicenter neuroimaging
52/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: This multimodal approach enhanced the system's performance and provided a clinically informative method for neuroimaging analysis.
Full summary, score breakdown and related studies → Original source
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2019-08-28
Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project
67/100 ✓ Peer-reviewed Caregiving Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The regulation of vasculature is a prominent causal component of probable AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-27
High-Need Phenotypes in Medicare Beneficiaries: Drivers of Variation in Utilization and Outcomes
55/100 ✓ Peer-reviewed Costs and economics Journal of the American Geriatrics Society
Key finding: Five phenotypes were identified: (1) comorbid ischemic heart disease with hospitalization and skilled nursing facility use (22% of the HN sample), (2) comorbid ischemic heart disease with home care use (23%), (3) home care use (12%), (4) high comorbidity with hospitalization (32%), and (5) Alzheimer's disease/related dementias with functional dependency and nursing home use (11%). +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-27
Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer's disease and associated with CSF-TAU and FDG-PET
39/100 ✓ Peer-reviewed Tau biomarkers Translational neurodegeneration
Key finding: Levels of KLK6 and KLK10 were significantly increased in AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-26
Optical Coherence Tomography Findings in Parkinson's and Alzheimer's Disease -Retinal Changes in Neurodegenerative Disease
41/100 ✓ Peer-reviewed Brain scans and imaging Noro psikiyatri arsivi
Key finding: OCT measurements did show significant decrease in temporal, nasal, inferiorR (R means examination of retina in two sections as superior and inferior instead of four quadrants) RNFL thickness and foveal, parafoveal, macular thickness of AD group compared to control group. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-26
Artificial intelligence as an emerging technology in the current care of neurological disorders
36/100 ✓ Peer-reviewed Digital health tools Journal of neurology
Key finding: The smart device system to monitor tremors and to recognize its phenotypes for better outcomes of deep brain stimulation, applications evaluating fine motor functions, AI integrated electroencephalogram learning to diagnose epilepsy and psychological non-epileptic seizure, predict outcome of seizure surgeries, recognize patterns of autonomic instability to prevent sudden unexpected death in epilepsy (SUDEP), identify the pattern of complex algorithm in neuroimaging classifying cognitive impairment, differentiating and classifying concussion phenotypes, smartwatches monitoring atrial fibrillation to prevent strokes, and prediction of prognosis in dementia are unique examples of experimental utilizations of AI in the field of neurology.
Full summary, score breakdown and related studies → Original source
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2019-08-26
Genetic predisposition, modifiable-risk-factor profile and long-term dementia risk in the general population
63/100 ✓ Peer-reviewed Prevention and risk Nature medicine
Key finding: In this study, we demonstrate that, in individuals at low and intermediate genetic risk, favorable modifiable-risk profiles are related to a lower risk of dementia compared to unfavorable profiles.
Full summary, score breakdown and related studies → Original source
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2019-08-25
Autoidentification of perivascular spaces in white matter using clinical field strength T1 and FLAIR MR imaging
49/100 ✓ Peer-reviewed Long-term cohort studies NeuroImage
Key finding: However, several publicly available datasets do not contain sequences required for recently published algorithms. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-23
Neuropathology of dementia in patients with Parkinson's disease: a systematic review of autopsy studies
67/100 ✓ Peer-reviewed Brain tissue and pathology Journal of neurology, neurosurgery, and psychiatry
Key finding: PD dementia (PDD) is associated with α-synuclein propagation, but coexistent Alzheimer's disease (AD) pathology may coexist. +3 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-23
[Bilateral hip fracture in a patient with Down syndrome]
28/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Anales del sistema sanitario de Navarra
Key finding: In our experience, one stage surgery for bilateral hip prosthesis is safe and provides good results in patients with severe mental impairment.
Full summary, score breakdown and related studies → Original source
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2019-08-22
Classification of Alzheimer's Disease with and without Imagery using Gradient Boosted Machines and ResNet-50
51/100 ✓ Peer-reviewed Digital health tools Brain sciences
Key finding: A gradient boosted machine (GBM) predicted the presence of AD as a function of gender, age, education, socioeconomic status (SES), and a mini-mental state exam (MMSE). +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-21
Diagnosing and Treating Depression in Patients with Alzheimer's Disease
39/100 ✓ Peer-reviewed Risk factors Neurology and therapy
Key finding: Although cognitive and functional impairment are the hallmark features of Alzheimer's disease (AD), neuropsychiatric symptoms associated with AD account for increased rates of disability and profoundly impact the quality of life of both patients and their caregivers. +1 more finding
Full summary, score breakdown and related studies → Original source
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2019-08-21
Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model
45/100 ✓ Peer-reviewed Inflammation and the immune system Nature communications
Key finding: We find that in the 5xFAD mouse model of AD, plaques fail to form in the parenchymal space following microglial depletion, except in areas containing surviving microglia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-21
Diabetes News
32/100 ✓ Peer-reviewed Health systems and care delivery Journal of Diabetes
Key finding: She presented compelling data that showed the vastly improved ease of use and overall satisfaction of nasal glucagon vs its injectable counterpart. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-21
Home Virtual Visits for Outpatient Follow-Up Stroke Care: Cross-Sectional Study
47/100 ✓ Peer-reviewed Health systems and care delivery Journal of Medical Internet Research
Key finding: The patients were aged 65 (56-73.5) years, and 39% (29/75) resided in rural areas. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-20
Deep Learning in Alzheimer's Disease: Diagnostic Classification and Prognostic Prediction Using Neuroimaging Data
72/100 ✓ Peer-reviewed Digital health tools Frontiers in aging neuroscience
Key finding: The combination of traditional machine learning for classification and stacked auto-encoder (SAE) for feature selection produced accuracies of up to 98.8% for AD classification and 83.7% for prediction of conversion from mild cognitive impairment (MCI), a prodromal stage of AD, to AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2019-08-20
Airborne, Vehicle-Derived Fe-Bearing Nanoparticles in the Urban Environment: A Review
38/100 ✓ Peer-reviewed Risk factors Environmental science & technology
Key finding: Exposure to nanosized (<0.1 μm), vehicle-derived particulates may be hazardous due to their bioreactivity, their ability to penetrate every organ, including the brain, and their abundance in the urban atmosphere. +4 more findings
Full summary, score breakdown and related studies → Original source
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