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Effects of Anserine/Carnosine Supplementation on Mild Cognitive Impairment with APOE4
Nobutaka Masuoka, Chitose Yoshimine, Marie Hori, Mieko Tanaka, Takashi Asada, Keiichi Abe, Tatsuhiro Hisatsune. Nutrients, 2019-07-17
Topic: Gut, metabolism and diet
The score improvement in the global Clinical Dementia Rating (gloCDR) was superior in the active group than placebo (p = 0.023). No beneficial effect in the active group was detected in the other psychometric tests including the Mini-Mental State Examination (MMSE), the Wechsler Memory Scale, and the Alzheimer's Disease Assessment Scale (ADAS). When APOE4 positive (APOE4 (+)) or negative (APOE4 (-)) subjects were separately analyzed, beneficial change in the APOE4 (+) subjects was observed in MMSE (p = 0.025) as well as in gloCDR (p = 0.026). The present study might suggest that protective effects against cognitive decline in APOE4 (+) MCI subjects exist.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Masuoka, N., Yoshimine, C., Hori, M., Tanaka, M., Asada, T., Abe, K., et al. (2019). Effects of Anserine/Carnosine Supplementation on Mild Cognitive Impairment with APOE4. Nutrients. https://doi.org/10.3390/nu11071626
Vancouver
Masuoka N, Yoshimine C, Hori M, Tanaka M, Asada T, Abe K, et al. Effects of Anserine/Carnosine Supplementation on Mild Cognitive Impairment with APOE4. Nutrients. 2019. doi:10.3390/nu11071626. PMID: 31319510.
BibTeX
@article{masuoka2019-31319510,
author = {Masuoka, Nobutaka and Yoshimine, Chitose and Hori, Marie and Tanaka, Mieko and Asada, Takashi and Abe, Keiichi and Hisatsune, Tatsuhiro},
title = {{Effects of Anserine/Carnosine Supplementation on Mild Cognitive Impairment with APOE4}},
journal = {Nutrients},
year = {2019},
doi = {10.3390/nu11071626},
pmid = {31319510},
url = {https://doi.org/10.3390/nu11071626}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- The score improvement in the global Clinical Dementia Rating (gloCDR) was superior in the active group than placebo (p = 0.023).
- No beneficial effect in the active group was detected in the other psychometric tests including the Mini-Mental State Examination (MMSE), the Wechsler Memory Scale, and the Alzheimer's Disease Assessment Scale (ADAS).
- When APOE4 positive (APOE4 (+)) or negative (APOE4 (-)) subjects were separately analyzed, beneficial change in the APOE4 (+) subjects was observed in MMSE (p = 0.025) as well as in gloCDR (p = 0.026).
- The present study might suggest that protective effects against cognitive decline in APOE4 (+) MCI subjects exist.
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Study details
- Evidence strengthHigh
How this study scored 73/100
Published in a peer-reviewed journal, and it is a randomized controlled trial. Scored zero for sample size and effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 41 of the 56 points we could judge it on, which is 73 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Nutrients) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 11 / 12 | A randomized controlled trial (from PubMed type “Randomized Controlled Trial”) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomized / blinded | 1 / 2 | Randomized (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31319510) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 41 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 41 of the 56 points we could judge it on is 73 out of 100. |
| Total | 73 / 100 | — |
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