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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 10,151–10,175 of 27,380 studies, newest first · page 407 of 1096.

June 2021 9

  1. 2021-06-01

    Associations between physical activity types and multi-domain cognitive decline in older adults from the Three-city cohort

    ✓ Peer-reviewed Prevention trials PloS one

    Key finding: Several studies suggest that physical activity improves cognitive functions and reduces cognitive decline, whereas others did not find any evidence of a neuroprotective effect. +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-06-01

    SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network

    ✓ Peer-reviewed Drug development Cell reports

    Key finding: We find that truncating mutation results in SORL1 haploinsufficiency and enlarged endosomes in human neurons. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2021-06-01

    Biomarkers for neurodegenerative diseases

    ✓ Peer-reviewed Biomarkers Nature Medicine

    Key finding: Positron emission tomography methods detecting amyloid-β and tau pathology in Alzheimer's disease have been increasingly used to improve the design of clinical trials and observational studies. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-06-01

    Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner

    ✓ Peer-reviewed Lewy body dementia Science (New York, N.Y.)

    Key finding: Using cultured human cells, we found that stress granule disassembly was context-dependent: Specifically in the setting of heat shock, disassembly required ubiquitination of G3BP1, the central protein within the stress granule RNA-protein network. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2021-06-01

    Social determinants of health in total knee arthroplasty : are social factors associated with increased 30-day post-discharge cost of care and length of stay?

    ✓ Peer-reviewed Disparities The bone & joint journal

    Key finding: Divorced marital status was significantly associated with an increased LOS following TKA. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-06-01

    Risk of Suicide Attempt in Patients With Recent Diagnosis of Mild Cognitive Impairment or Dementia

    ✓ Peer-reviewed Disparities JAMA psychiatry

    Key finding: Most studies have focused on dementia and suicidal behavior, with inconsistent results. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2021-06-01

    Assessment of Racial/Ethnic Disparities in Timeliness and Comprehensiveness of Dementia Diagnosis in California

    ✓ Peer-reviewed Caregiving JAMA neurology

    Key finding: These findings highlight substantial disparities in the timeliness and comprehensiveness of dementia diagnosis. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-06-01

    Association of APOE ε4 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: A cross-sectional study

    ✓ Peer-reviewed Genetics PLoS medicine

    Key finding: Apolipoprotein E (APOE) ε4 is the single most important genetic risk factor for cognitive impairment and Alzheimer disease (AD), while lifestyle factors such as smoking, drinking, diet, and physical activity also have impact on cognition. +2 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-06-01

    Finding Treatment Effects in Alzheimer Trials in the Face of Disease Progression Heterogeneity

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: Individuals with early AD show heterogeneity in disease progression, which increases when stratifying on risk factors associated with progression. +2 more findings

    Full summary, score breakdown and related studies → Original source

May 2021 16

  1. 2021-05-31

    Autophagy and ALS: mechanistic insights and therapeutic implications

    ✓ Peer-reviewed Disease mechanisms Autophagy

    Key finding: In line with this, mutations in genes that encode essential autophagy factors result in impaired autophagy and lead to neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS).

    Full summary, score breakdown and related studies → Original source

  2. 2021-05-31

    Sensorineural hearing loss may lead to dementia-related pathological changes in hippocampal neurons

    ✓ Peer-reviewed Risk factors Neurobiology of disease

    Key finding: The results showed that neurons began to degenerate 60 days after hearing loss, and this degeneration was accompanied by structural disorganization and decreased neurogenesis. +1 more finding

    Full summary, score breakdown and related studies → Original source

  3. 2021-05-31

    Patterns of tau pathology identified with 18 F-MK-6240 PET imaging

    ✓ Peer-reviewed Brain scans and imaging Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: 18 F-MK-6240 recapitulated Braak staging and correlated with CSF tau and p-tau, normalized to Aβ42 . 18 F-MK-6240 negatively correlated with age across Braak regions in amyloid-positive participants, consistent with greater tau pathology in earlier onset AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2021-05-31

    A blood screening tool for detecting mild cognitive impairment and Alzheimer's disease among community-dwelling Mexican Americans and non-Hispanic Whites: A method for increasing representation of diverse populations in clinical research

    ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: A blood-based screening tool can serve as a method for increasing access to state-of-the-art AD clinical research by bridging between community-based and clinic-based settings. +1 more finding

    Full summary, score breakdown and related studies → Original source

  5. 2021-05-31

    A Fay-Herriot Model for Estimating Subjective Cognitive Decline among Military Veterans

    ✓ Peer-reviewed Risk factors The Journal of Prevention of Alzheimer s Disease

    Key finding: Direct survey-weighted rates were correlated with model-predicted rates in 43 counties (Pearson r = 0.32). +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-05-30

    Genetic underpinnings of sociability in the general population

    ✓ Peer-reviewed Genetics Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    Key finding: The score was significantly heritable (SNP h2 of 6%). +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2021-05-29

    Sex differences in off-target binding using tau positron emission tomography

    ✓ Peer-reviewed Brain scans and imaging NeuroImage. Clinical

    Key finding: Voxel-wise analysis showed higher meningeal off-target binding in women compared to men across all three tracers. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-05-29

    Protective properties of GLP-1 and associated peptide hormones in neurodegenerative disorders

    ✓ Peer-reviewed Drug development British journal of pharmacology

    Key finding: The improved neuroprotective effects of these drugs suggest that they are superior to single GLP-1 receptor agonists and could provide disease-modifying care for Alzheimer's disease and Parkinson's disease patients.

    Full summary, score breakdown and related studies → Original source

  9. 2021-05-29

    Emerging Concepts in Vascular Dementia: A Review

    ✓ Peer-reviewed Digital health tools Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    Key finding: This review should serve as a compendium of updated information on VaD and provide guidance in terms of newer diagnostic and potential therapeutic approaches. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2021-05-28

    Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension

    ✓ Peer-reviewed Caregiving Nature reviews. Cardiology

    Key finding: In 2015, an estimated 8.5 million deaths were attributable to systolic blood pressure >115 mmHg, 88% of which were in low-income and middle-income countries. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2021-05-28

    Dimethyl fumarate abridged tauo-/amyloidopathy in a D-Galactose/ovariectomy-induced Alzheimer's-like disease: Modulation of AMPK/SIRT-1, AKT/CREB/BDNF, AKT/GSK-3β, adiponectin/Adipo1R, and NF-κB/IL-1β/ROS trajectories

    ✓ Peer-reviewed Biomarkers Neurochemistry international

    Key finding: DMF succeeded to ameliorate cognitive (learning/short- and long-term memory) deficits and to enhance the dampened overall activity (NOR, Barnes-/Y-maze tests). +1 more finding

    Full summary, score breakdown and related studies → Original source

  12. 2021-05-27

    Hemostasis components in cerebral amyloid angiopathy and Alzheimer's disease

    ✓ Peer-reviewed Vascular contributions Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    Key finding: This review discusses the contribution of hemostasis components to Aβ cerebrovascular deposition, which settle the way to endothelial and blood-brain barrier dysfunction, vessel fragility, cerebral bleeding, and the associated cognitive changes. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2021-05-27

    Obstructive Sleep Apnea and Cognitive Decline: A Review of Potential Vulnerability and Protective Factors

    ✓ Peer-reviewed Risk factors Brain sciences

    Key finding: However, despite several epidemiological studies investigating the link between OSA and cognitive decline, there is still no consensus on whether OSA increases the risk of dementia or not. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021-05-27

    Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET

    ✓ Peer-reviewed Brain scans and imaging Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    Key finding: Cortical clusters of 4R-tau cases indicated higher delivery (R1SRTM: 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2SRTM: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p < 0.0001), lower DVR (1.1 ± 0.1 vs. 1.4 ± 0.2, p < 0.0001), lower SUVR30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p < 0.0001) and flatter slopes of the post-perfusion phase (slope9-60: 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p < 0.0001) when compared to 3/4R-tau cases. [18F]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2021-05-27

    Targeting γ-Secretase for Familial Alzheimer's Disease

    ✓ Peer-reviewed Risk genes beyond APOE Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents

    Key finding: Recent findings reveal that FAD mutations in PSEN1 and in APP result in deficient trimming of initially formed long Aβ peptides. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2021-05-27

    Amyloid beta associations with connected speech in cognitively unimpaired adults

    ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: These results indicate that declines in connected speech may be related to preclinical AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →