Newest studies

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

61/100 ✓ Peer-reviewed Lewy body dementia Nature

Key finding: First, we crossed ataxin-2 knockout mice with TDP-43 (also known as TARDBP) transgenic mice. +4 more findings

• Brain Biology
• Treatments
• Other Dementias

Full summary, score breakdown and related studies → Original source

Palliative Care in Huntington Disease: Personal Reflections and a Review of the Literature

39/100 ✓ Peer-reviewed Caregiving Tremor and other hyperkinetic movements (New York, N.Y.)

Key finding: We provide a review of the current literature and discuss our own care practices. +1 more finding

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Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro

48/100 ✓ Peer-reviewed Tau biomarkers The American journal of pathology

Key finding: If so, targeting extracellular tau species may slow the spreading of tau pathology and possibly cognitive decline. +3 more findings

• Brain Biology

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DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease

39/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of psychiatric research

Key finding: Recent genome-wide association studies revealed that Triggering receptor expressed on myeloid cells 2 (TREM2) was associated with Alzheimer's disease (AD) and other neurodegenerative diseases. +3 more findings

• Genetics

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Interactions of pathological proteins in neurodegenerative diseases

56/100 ✓ Peer-reviewed Lewy body dementia Acta neuropathologica

Key finding: We conclude that there is evidence for interactions at the molecular level as well as for additive effects on brain damage by multiple pathologies occurring in different functionally important neurons.

• Other Dementias
• Brain Biology

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Increased Diagnostic Accuracy of Digital vs. Conventional Clock Drawing Test for Discrimination of Patients in the Early Course of Alzheimer's Disease from Cognitively Healthy Individuals

51/100 ✓ Peer-reviewed Digital health tools Frontiers in aging neuroscience

Key finding: The diagnostic value of a newly developed digital Clock Drawing Test (dCDT) was evaluated and compared with the cCDT in 20 patients with early dementia due to AD (eDAT), 30 patients with amnestic MCI (aMCI) and 20 cognitively healthy controls (HCs). +3 more findings

• Diagnosis
• Digital Tools

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Simultaneous usage of dementia medications and anticholinergics among Asians and Pacific Islanders

52/100 ✓ Peer-reviewed Treatments Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Key finding: Overall, 304 patients receiving cholinesterase inhibitors/memantine also received anticholinergics. +4 more findings

• Treatments
• Side Effects

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African American exome sequencing identifies potential risk variants at Alzheimer disease loci

52/100 ✓ Peer-reviewed Genetics Neurology. Genetics

Key finding: Two ABCA7 missense variants (rs3764647 and rs3752239) demonstrated significant association with AD risk. +3 more findings

• Genetics
• Health Equity

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Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases

41/100 ✓ Peer-reviewed Inflammation and the immune system International journal of molecular sciences

Key finding: In this review, we emphasized the major advances made over the last 20 years, thanks to TSPO PET imaging, to define the pathophysiological implication of microglia activation and neuroinflammation in neurodegenerative diseases, including Parkinson's disease, Huntington's disease, dementia, amyotrophic lateral sclerosis, multiple sclerosis, and also in psychiatric disorders. +4 more findings

• Brain Scans
• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

RNA-binding proteins with prion-like domains in health and disease

50/100 ✓ Peer-reviewed Lewy body dementia The Biochemical journal

Key finding: In humans, PrLDs contribute to RBP function and enable RBPs to undergo liquid-liquid phase transitions that underlie the biogenesis of various membraneless organelles. +4 more findings

• Other Dementias

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Roles of tau protein in health and disease

43/100 ✓ Peer-reviewed Disease mechanisms Acta neuropathologica

Key finding: Recent advances in our understanding of the multiple functions and different locations of tau inside and outside neurons have revealed novel insights into its importance in a diverse range of molecular pathways including cell signalling, synaptic plasticity, and regulation of genomic stability.

• Brain Biology

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Liraglutide Improves Water Maze Learning and Memory Performance While Reduces Hyperphosphorylation of Tau and Neurofilaments in APP/PS1/Tau Triple Transgenic Mice

38/100 ✓ Peer-reviewed Drug development Neurochemical research

Key finding: Liraglutide did not significantly affect the animals' body weight (BW) or fasting blood glucose.

• Brain Biology
• Biomarkers
• Digital Tools

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Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline

41/100 ✓ Peer-reviewed Brain scans and imaging Annals of neurology

Key finding: Our study identified a synergistic effect of amyloid and tau deposits and demonstrated, for the first time, in normal elderly its link to AD-like hypometabolism and to AD-like memory decline. +4 more findings

• Brain Scans

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A phase 3 trial of IV immunoglobulin for Alzheimer disease

76/100 ✓ Peer-reviewed Clinical trials Neurology

Key finding: No beneficial effects were observed in the dual primary outcome measures for the 2 IVIg doses tested. +4 more findings

• Clinical Trials

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Response of the cerebral vasculature following traumatic brain injury

38/100 ✓ Peer-reviewed Vascular contributions Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Key finding: TBI often results in significant injury to the vasculature in the brain with subsequent cerebral hypoperfusion, ischemia, hypoxia, hemorrhage, blood-brain barrier disruption and edema. +2 more findings

• Risk Factors

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Netrin-1 improves the amyloid-β-mediated suppression of memory and synaptic plasticity

39/100 ✓ Peer-reviewed Disease mechanisms Brain research bulletin

Key finding: However, only by repeated injection of NT-1, significant recovery of LTP and memory was seen. +1 more finding

• Brain Biology

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Cortical laminar tau deposits and activated astrocytes in Alzheimer's disease visualised by 3H-THK5117 and 3H-deprenyl autoradiography

44/100 ✓ Peer-reviewed Biomarkers Scientific reports

Key finding: We here aimed to visualize in vitro the distribution of tau deposits and activated astrocytes across the cortical layers in autopsy AD brain tissue using the radiotracers 3 H-THK5117 and 3 H-deprenyl. 3 H-THK5117 and 3 H-deprenyl autoradiographies were carried out on frozen brain sections from three AD patients and one healthy control. 3 H-THK5117 showed a distinct laminar cortical binding similar to 3 H-deprenyl autoradiography, with an extensive binding in the superficial and deep layers of the temporal neocortices, whereas the middle frontal gyrus showed an even binding throughout the layers. +4 more findings

• Brain Biology

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Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease

45/100 ✓ Peer-reviewed Disease mechanisms Nature communications

Key finding: Here, we found an age-dependent DAergic neuron loss in the ventral tegmental area (VTA) at pre-plaque stages, although substantia nigra pars compacta (SNpc) DAergic neurons were intact. +2 more findings

• Brain Biology

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End-of-Life Care Transition Patterns of Medicare Beneficiaries

53/100 ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

Key finding: Approximately one-third of the Medicare beneficiaries who died in 2011 had four or more transitions within their last 6 months of life. +2 more findings

• End-of-Life Care
• Policy

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Control of mitochondrial biogenesis and function by the ubiquitin-proteasome system

39/100 ✓ Peer-reviewed Disease mechanisms Open biology

Key finding: The pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, has been associated with mitochondrial and proteostasis failure.

• Brain Biology

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Cognitive reserve and cortical thickness in preclinical Alzheimer's disease

64/100 ✓ Peer-reviewed Risk factors Brain imaging and behavior

Key finding: This study examined whether cognitive reserve (CR) alters the relationship between magnetic resonance imaging (MRI) measures of cortical thickness and risk of progression from normal cognition to the onset of clinical symptoms associated with mild cognitive impairment (MCI). +2 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

Circadian Disruption Associated with Alzheimer's Disease

39/100 ✓ Peer-reviewed Risk factors Current neurology and neuroscience reports

Key finding: Alzheimer's disease (AD) is increasing in prevalence and has a significant impact on caregivers and the healthcare system.

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Multi-Domain Transfer Learning for Early Diagnosis of Alzheimer's Disease

48/100 ✓ Peer-reviewed Prevention trials Neuroinformatics

Key finding: The experimental results show that the proposed MDTL method can effectively utilize multi-auxiliary domain data for improving the learning performance in the target domain, compared with several state-of-the-art methods.

• Diagnosis
• Brain Scans

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Direct and indirect cost of managing alzheimer's disease and related dementias in the United States

38/100 ✓ Peer-reviewed Caregiving Expert review of pharmacoeconomics & outcomes research

Key finding: Care of individuals with Alzheimer's Disease and Related Dementias (ADRD) poses special challenges. +4 more findings

• Policy

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iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

38/100 ✓ Peer-reviewed Inflammation and the immune system Neuron

Key finding: Together, these findings demonstrate that iMGLs can be used to study microglial function, providing important new insight into human neurological disease.

• Brain Biology

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