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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 9,976–10,000 of 27,380 studies, newest first · page 400 of 1096.

July 2021 25

  1. 2021-07-22

    Air Pollution: A Neglected Risk Factor for Dementia in Latin America and the Caribbean

    ✓ Peer-reviewed Risk factors Frontiers in neurology

    Key finding: Several cohort studies have indicated that air pollution increases the risk of developing dementia and neurodegenerative diseases, but the mechanisms underlying the association are still not clear. +1 more finding

    Full summary, score breakdown and related studies → Original source

  2. 2021-07-22

    Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?

    ✓ Peer-reviewed Genetics The Journal of experimental medicine

    Key finding: In mouse AD models, single-cell RNA sequencing (scRNA-seq) analyses delineated this response as progressive conversion of homeostatic microglia into disease-associated microglia (DAM); additional reactive microglial populations have been reported in other models of neurodegeneration and neuroinflammation. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-07-22

    Validity and Cultural Generalisability of a 5-Minute AI-Based, Computerised Cognitive Assessment in Mild Cognitive Impairment and Alzheimer's Dementia

    ✓ Peer-reviewed Cognitive tests and assessment Frontiers in psychiatry

    Key finding: The ICA demonstrated convergent validity with MoCA (Pearson r=0.58, p<0.0001) and ACE (r=0.62, p<0.0001). +4 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-07-21

    Plasma Neurofilament Light and Future Declines in Cognition and Function in Alzheimer's Disease in the FIT-AD Trial

    ✓ Peer-reviewed Biomarkers Journal of Alzheimer's disease reports

    Key finding: Higher baseline plasma NfL was associated with greater rate of decline in ADAS-Cog from baseline to 6 months (standardized estimate of 0.00462, p = 0.02853) and in ADL from baseline to 12 months (standardized estimate of -0.00284, p = 0.03338). +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021-07-21

    Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model

    ✓ Peer-reviewed Drug development Protein & cell

    Key finding: We delineate the mechanism of CMA induction by Metformin to be via activation of TAK1-IKKα/β signaling that leads to phosphorylation of Ser85 of the key mediator of CMA, Hsc70, and its activation. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-07-21

    Speech-in-noise hearing impairment is associated with an increased risk of incident dementia in 82,039 UK Biobank participants

    ✓ Peer-reviewed Digital health tools Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: SiN hearing impairment is independently associated with incident dementia, providing further evidence for hearing impairment as a potential modifiable dementia risk factor. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2021-07-20

    Fecal Microbiota Transplantation: A Microbiome Modulation Technique for Alzheimer's Disease

    ✓ Peer-reviewed Disease mechanisms Cureus

    Key finding: Although the association between the imbalance of gut microbiota and AD is still difficult to determine, it has been suggested that dysbiosis can lead to the increased secretion of lipopolysaccharides and amyloid, which may impair the permeability of the intestine and the blood-brain barrier.

    Full summary, score breakdown and related studies → Original source

  8. 2021-07-20

    Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice

    ✓ Peer-reviewed Drug development Experimental brain research

    Key finding: Some studies have demonstrated that metformin exerts neuroprotective, anti-inflammatory, anti-oxidant, and nootropic effects. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2021-07-20

    Current advances in digital cognitive assessment for preclinical Alzheimer's disease

    ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: Digital assessments varied by intended setting (e.g., remote vs. in-clinic), level of supervision (e.g., self vs. supervised), and device origin (personal vs. study-provided). +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2021-07-20

    Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia

    ✓ Peer-reviewed Mild cognitive impairment Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

    Key finding: So far, only repetitive TMS (rTMS) over the left dorsolateral prefrontal cortex and multisite rTMS associated with cognitive training have been shown to be, respectively, possibly (Level C of evidence) and probably (Level B of evidence) effective to improve cognition, apathy, memory, and language in AD patients, especially at a mild/early stage of the disease.

    Full summary, score breakdown and related studies → Original source

  11. 2021-07-20

    Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity

    ✓ Peer-reviewed Down syndrome and Alzheimer's PloS one

    Key finding: In the current study, we characterized the crGART versus HeLa transcriptomes in purine-supplemented and purine-depleted growth conditions. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-07-19

    Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients

    ✓ Peer-reviewed Clinical safety The Cochrane database of systematic reviews

    Key finding: There is moderate-certainty evidence regarding the benefit of multicomponent non-pharmacological interventions for the prevention of delirium in hospitalised adults, estimated to reduce incidence by 43% compared to usual care. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2021-07-19

    Post-infection cognitive impairments in a cohort of elderly patients with COVID-19

    ✓ Peer-reviewed Clinical safety Molecular neurodegeneration

    Key finding: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with an increased risk of long-term cognitive decline in elderly population. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2021-07-18

    Role of TREM2 in Alzheimer's Disease: A Long Road Ahead

    ✓ Peer-reviewed TREM2 and immune genetics Molecular neurobiology

    Key finding: Numerous studies on mice models have revealed the relationship between mutations of TREM2 gene and its effect on amyloid burden and tau pathology in the brain that gets affected by AD.

    Full summary, score breakdown and related studies → Original source

  15. 2021-07-18

    APOE Genotype and Alzheimer's Disease: The Influence of Lifestyle and Environmental Factors

    ✓ Peer-reviewed Risk factors ACS chemical neuroscience

    Key finding: A growing amount of epidemiological evidence suggests that several lifestyle habits and environmental factors may interact with APOE alleles to synergistically affect the risk of AD development.

    Full summary, score breakdown and related studies → Original source

  16. 2021-07-17

    Effects of 1 Year of Lifestyle Intervention on Institutionalized Older Adults

    ✓ Peer-reviewed Prevention trials International journal of environmental research and public health

    Key finding: The socio-economic and health consequences of our ageing population are well documented, with older adults living in long-term care facilities amongst the frailest possessing specific and significant healthcare and social care needs. +2 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021-07-17

    A cross-sectional study in healthy elderly subjects aimed at development of an algorithm to increase identification of Alzheimer pathology for the purpose of clinical trial participation

    ✓ Peer-reviewed Tau biomarkers Alzheimer's research & therapy

    Key finding: In the current study, we aimed to develop an algorithm based on biomarkers obtained through non- or minimally invasive procedures to identify healthy elderly subjects who have an increased risk of abnormal cerebrospinal fluid (CSF) amyloid beta42 (Aβ) levels consistent with the presence of Alzheimer's disease (AD) pathology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-07-16

    Structural Brain Changes Associated with Overweight and Obesity

    ✓ Peer-reviewed Risk factors Journal of obesity

    Key finding: Adipocytes, macrophages of the adipose tissue, and gut dysbiosis in overweight and obese individuals result in the secretion of the cytokines and chemokines that cross the blood-brain barrier and may stimulate microglia, which in turn also release proinflammatory cytokines. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2021-07-16

    Recent advances in drug repurposing using machine learning

    ✓ Peer-reviewed Drug development Current opinion in chemical biology

    Key finding: Drug repurposing aims to find new uses for already existing and approved drugs. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2021-07-15

    Biodegradable polymers and their nano-composites for the removal of endocrine-disrupting chemicals (EDCs) from wastewater: A review

    ✓ Peer-reviewed Risk factors Environmental research

    Key finding: These polymers could be either natural, synthetic, or a combination of both. +4 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2021-07-15

    Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation

    ✓ Peer-reviewed Biomarkers Acta pharmacologica Sinica

    Key finding: We showed that luteolin treatment dose-dependently improved spatial learning, ameliorated memory deficits in 3 × Tg-AD mice, accompanied by inhibiting astrocyte overactivation (GFAP) and neuroinflammation (TNF-α, IL-1β, IL-6, NO, COX-2, and iNOS protein), and decreasing the expression of endoplasmic reticulum (ER) stress markers GRP78 and IRE1α in brain tissues. +2 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2021-07-15

    "Drugs to avoid" to improve quality use of medicines: how is Australia faring?

    ✓ Peer-reviewed Health systems and care delivery Journal of pharmaceutical policy and practice

    Key finding: These results raise serious concerns about the awareness of Australian clinicians of medicine safety and efficacy.

    Full summary, score breakdown and related studies → Original source

  23. 2021-07-15

    Increased risk for dementia in neurofibromatosis type 1

    ✓ Peer-reviewed Health systems and care delivery Genetics in medicine : official journal of the American College of Medical Genetics

    Key finding: A Finnish cohort of 1,349 individuals with confirmed NF1 according to the US National Institutes of Health (NIH) diagnostic criteria was compared with a control cohort of 13,870 individuals matched for age, sex, and area of residence. +1 more finding

    Full summary, score breakdown and related studies → Original source

  24. 2021-07-15

    Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia

    ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration

    Key finding: Microglia are active modulators of Alzheimer's disease but their role in relation to amyloid plaques and synaptic changes due to rising amyloid beta is unclear. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2021-07-15

    Association between Inflammatory Conditions and Alzheimer's Disease Age of Onset in Down Syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Journal of clinical medicine

    Key finding: Adults with Down syndrome (DS) have an exceptionally high prevalence of Alzheimer disease (AD), with an earlier age of onset compared with the neurotypical population. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →