Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,976–25,000 of 27,380 studies, newest first · page 1000 of 1096.
January 2002 16
-
2002-01-01
Patterns of brain atrophy in frontotemporal dementia and semantic dementia
54/100 ✓ Peer-reviewed Lewy body dementia Neurology
Key finding: Although FTD and SemD are associated with different overall patterns of brain atrophy, regions of gray matter tissue loss in the orbital frontal, insular, and anterior cingulate regions are present in both groups. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2002-01-01
Patterns of cerebral atrophy in primary progressive aphasia
39/100 ✓ Peer-reviewed Digital health tools The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: The syndrome may be associated with frontotemporal dementia (FTD)- or Alzheimer disease (AD)-type changes. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2002-01-01
Neuropsychiatric features of frontotemporal dementia: evaluation of consensus criteria and review
40/100 ✓ Peer-reviewed Digital health tools The Journal of neuropsychiatry and clinical neurosciences
Key finding: The authors evaluated the neuropsychiatric features of 53 FTD patients and retrospectively applied the Consensus Criteria for this disorder. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2002-01-01
Rivastigmine for the treatment of dementia and visual hallucinations associated with Parkinson's disease: a case series
41/100 ✓ Peer-reviewed Digital health tools Current medical research and opinion
Key finding: Here, we present a case series of patients with Parkinson's disease and dementia who we treated with rivastigmine, a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) that shows brain region-selectivity. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2002-01-01
Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease
44/100 ✓ Peer-reviewed Treatments CNS drug reviews
Key finding: It is extensively metabolized in numerous pathways, mainly in the liver via cytochrome P450 enzymes CYP2D6 and CYP3A4, and has a low potential for clinically significant drug-drug interactions. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2002-01-01
Postmortem MRI and histopathology of white matter changes in Alzheimer brains. A quantitative, comparative study
40/100 ✓ Peer-reviewed Brain scans and imaging Dementia and geriatric cognitive disorders
Key finding: However, pathology showed significantly more extensive changes than did MRI in all cases, with a mean of 54% larger areas.
Full summary, score breakdown and related studies → Original source
-
2002-01-01
[Reliability and validity of the standardized Mini Mental State Examination in the diagnosis of mild dementia in Turkish population]
45/100 ✓ Peer-reviewed Getting a diagnosis Turk psikiyatri dergisi = Turkish journal of psychiatry
Key finding: The results of this study showed that the Turkish version of the SMMSE has high reliability and validity for the diagnosis of mild dementia in Turkish population. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2002-01-01
Excessive daytime sleepiness and sudden-onset sleep in Parkinson disease: a survey by the Canadian Movement Disorders Group
55/100 ✓ Peer-reviewed Getting a diagnosis JAMA
Key finding: Excessive daytime sleepiness was present overall in 327 (51%) of the 638 patients and in 213 (51%) of the 420 drivers. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2002-01-01
Incidence of dementia, Alzheimer's disease, and vascular dementia in Italy. The ILSA Study
60/100 ✓ Peer-reviewed Prevention and risk Journal of the American Geriatrics Society
Key finding: Incidence of dementia in Italy paralleled that in most industrialized countries. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2002-01-01
The risk-benefit profile of commonly used herbal therapies: Ginkgo, St. John's Wort, Ginseng, Echinacea, Saw Palmetto, and Kava
63/100 ✓ Peer-reviewed Prevention and risk Annals of internal medicine
Key finding: The published evidence suggests that ginkgo is of questionable use for memory loss and tinnitus but has some effect on dementia and intermittent claudication.
Full summary, score breakdown and related studies → Original source
-
2002-01-01
H2 histamine receptor blockade in the treatment of Alzheimer disease: a randomized, double-blind, placebo-controlled trial of nizatidine
55/100 ✓ Peer-reviewed Treatments Alzheimer disease and associated disorders
Key finding: These results do not support claims for the efficacy of nizatidine in over-the-counter dosages as a means of preventing symptom progression in AD. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2002-01-01
HMG-CoA reductase inhibitors (statins) in the treatment of Alzheimer's disease and why it would be ill-advise to use one that crosses the blood-brain barrier
55/100 ✓ Peer-reviewed Treatments The journal of nutrition, health & aging
Key finding: Increased circulating cholesterol has been long linked to an increased risk of coronary artery disease (CAD), and is now linked to an increased risk of developing Alzheimer s disease (AD). +2 more findings
Full summary, score breakdown and related studies → Original source
-
2002-01-01
Snoezelen for dementia
55/100 ✓ Peer-reviewed Treatments The Cochrane database of systematic reviews
Key finding: Practitioners are keen to use snoezelen in dementia care, and some encouraging results have been documented in the area of promoting adaptive behaviours (e.g. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2002-01-01
Specificity of brain activation patterns in people at genetic risk for Alzheimer disease
43/100 ✓ Peer-reviewed Genetics The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Key finding: However, the two genetic groups showed no differences in activation patterns even at the most difficult task level, suggesting that additional cognitive effort in persons at genetic risk for AD is specific to episodic encoding and is not merely a reflection of task difficulty.
Full summary, score breakdown and related studies → Original source
-
2002-01-01
Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet
36/100 ✓ Peer-reviewed Genetics The journal of nutrition, health & aging
Key finding: Although plasma cholesterol levels are not generally associated with Alzheimer disease (AD) incidence, in vitro studies have found that increased cellular cholesterol levels are associated with increases in -amyloid (A ) production, with a concomitant decrease in sAPPa, the secreted non amyloidogenic fragment of the amyloid precursor protein (APP). +4 more findings
Full summary, score breakdown and related studies → Original source
-
2002-01-01
Risk of dementia among white and African American relatives of patients with Alzheimer disease
55/100 ✓ Peer-reviewed Genetics JAMA
Key finding: However, in this study, the additional risk of dementia conferred by being a first-degree relative, by being female, or by the probability of having an APOE epsilon4 allele appeared similar in African American and white families.
Full summary, score breakdown and related studies → Original source
December 2001 9
-
2001-12-20
The synucleins
40/100 ✓ Peer-reviewed Brain scans and imaging Genome biology
Key finding: Mutations in alpha-synuclein are associated with rare familial cases of early-onset Parkinson's disease, and the protein accumulates abnormally in Parkinson's disease, Alzheimer's disease, and several other neurodegenerative illnesses.
Full summary, score breakdown and related studies → Original source
-
2001-12-13
A sensitive and quantitative assay for measuring cleavage of presenilin substrates
39/100 ✓ Peer-reviewed Risk genes beyond APOE The Journal of biological chemistry
Key finding: Here we present a novel cell-based reporter gene assay for the quantification of PS-controlled gamma-secretase cleavage of the Alzheimer amyloid precursor protein (APP). +3 more findings
Full summary, score breakdown and related studies → Original source
-
2001-12-01
Neurosteroid metabolism in the human brain
36/100 ✓ Peer-reviewed Risk factors European Journal of Endocrinology
Key finding: This review summarizes the current knowledge of the biosynthesis of neurosteroids in the human brain, the enzymes mediating these reactions, their localization and the putative effects of neurosteroids. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2001-12-01
Prevalence of depression and depression recognition in nursing homes
40/100 ✓ Peer-reviewed Health systems and care delivery Social psychiatry and psychiatric epidemiology
Key finding: The prevalence of depressive disorders among nursing home residents is high; depression recognition is relatively low, with only 37%-45% of cases diagnosed by psychiatrists recognized as depressed by staff. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2001-12-01
Apathy in Alzheimer's disease
36/100 ✓ Peer-reviewed Caregiving Journal of the American Geriatrics Society
Key finding: Patients with apathy suffer from decreased daily function and specific cognitive deficits and rely on families to provide more care, which results in increased stress for families. +1 more finding
Full summary, score breakdown and related studies → Original source
-
2001-12-01
Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide
36/100 ✓ Peer-reviewed Disease mechanisms Trends in molecular medicine
Key finding: Recent research suggests that these observations might be linked, and it is postulated that Abeta-induced oxidative stress leads to neurodegeneration in AD brain.
Full summary, score breakdown and related studies → Original source
-
2001-12-01
Invited review: Estrogens effects on the brain: multiple sites and molecular mechanisms
36/100 ✓ Peer-reviewed Disease mechanisms Journal of applied physiology (Bethesda, Md. : 1985)
Key finding: However, we also find nonnuclear estrogen receptors outside of the cell nuclei in dendrites, presynaptic terminals, and glial cells, where estrogen receptors may couple to second messenger systems to regulate a variety of cellular events and signal to the nuclear via transcriptional regulators such as CREB. +4 more findings
Full summary, score breakdown and related studies → Original source
-
2001-12-01
Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier
36/100 ✓ Peer-reviewed Vascular contributions Trends in neurosciences
Key finding: Disruption of the tight junctions (TJs) of the blood-brain barrier (BBB) is a hallmark of many CNS pathologies, including stroke, HIV encephalitis, Alzheimer's disease, multiple sclerosis and bacterial meningitis. +3 more findings
Full summary, score breakdown and related studies → Original source
-
2001-12-01
Effect of apolipoprotein E genotype on hippocampal volume loss in aging healthy women
43/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurology
Key finding: The presence of a single APOE-epsilon4 allele is associated with an increased rate of hippocampal volume loss in healthy women in their sixth decade of life that is not related to any detectable memory changes. +3 more findings
Full summary, score breakdown and related studies → Original source
Browse the library by subject, with the full score breakdown →