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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 11,676–11,700 of 27,380 studies, newest first · page 468 of 1096.

May 2020 8

  1. 2020-05-01

    Associations Between Cardiovascular Risk, Structural Brain Changes, and Cognitive Decline

    ✓ Peer-reviewed Caregiving Journal of the American College of Cardiology

    Key finding: Higher cardiovascular risk burden may predict decline in episodic memory, working memory, and perceptual speed and is associated with neurodegeneration and vascular lesions in the brain. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2020-05-01

    Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts

    ✓ Peer-reviewed Getting a diagnosis The Lancet. Neurology

    Key finding: Concentrations of plasma p-tau181 were compared with established CSF and PET biomarkers and longitudinal measurements using Spearman correlation, area under the curve (AUC), and linear regression analyses.

    Full summary, score breakdown and related studies → Original source

  3. 2020-05-01

    A Systematic Review of Clinical Studies on the Effect of Psychoactive Cannabinoids in Psychiatric Conditions in Alzheimer Dementia

    ✓ Peer-reviewed Treatments American journal of therapeutics

    Key finding: No clear conclusion can be drawn on the effectiveness of psychoactive cannabinoids in the treatment of psychiatric manifestations, in particular agitation and aggression, in AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2020-05-01

    Bupropion for the Treatment of Apathy in Alzheimer Disease: A Randomized Clinical Trial

    ✓ Peer-reviewed Treatments JAMA network open

    Key finding: After controlling for the baseline AES-C score, site, and comedication with donepezil or galantamine, the mean change in the AES-C score between the bupropion and placebo groups was not statistically significant (mean change, 2.22; 95% CI, -0.47 to 4.91; P = .11). +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2020-05-01

    Comparison of Integrated Outpatient Palliative Care With Standard Care in Patients With Parkinson Disease and Related Disorders: A Randomized Clinical Trial

    ✓ Peer-reviewed Treatments JAMA neurology

    Key finding: Outpatient PC is associated with benefits among patients with PDRD compared with standard care alone. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2020-05-01

    Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers

    ✓ Peer-reviewed Genetics Neurology

    Key finding: This study shows that PUTG component scores were significantly associated with diagnostic group and AD biomarkers, a finding that was more pronounced in APOE ε4 carriers. +4 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2020-05-01

    Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease

    ✓ Peer-reviewed Genetics JAMA neurology

    Key finding: Higher educational level (standardized β = 0.23, P Conclusions and relevance Results of this study suggest that women and young patients with AD have relative preservation of brain structure when exposed to neocortical pathological tau. +2 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2020-05-01

    Reshaping the Amyloid Buildup Curve in Alzheimer Disease? Partial-Volume Effect Correction of Longitudinal Amyloid PET Data

    ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    Key finding: Compared with non-PVE-corrected data, PVE-corrected data yielded significantly higher changes in regional and composite SUV ratio (SUVR) over time ( P = 0.0002 for composite SUVRs). +3 more findings

    Full summary, score breakdown and related studies → Original source

April 2020 17

  1. 2020-04-30

    The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer's Disease

    ✓ Peer-reviewed Genetics Frontiers in immunology

    Key finding: ApoE4 constitutes an increased risk of AD, with one copy increasing the risk about 4-fold and two copies increasing the risk about 15-fold compared to those with the ApoE3 allele.

    Full summary, score breakdown and related studies → Original source

  2. 2020-04-30

    Neurophysiological Hallmarks of Neurodegenerative Cognitive Decline: The Study of Brain Connectivity as A Biomarker of Early Dementia

    ✓ Peer-reviewed Digital health tools Journal of personalized medicine

    Key finding: Neurodegenerative processes of various types of dementia start years before symptoms, but the presence of a "neural reserve", which continuously feeds and supports neuroplastic mechanisms, helps the aging brain to preserve most of its functions within the "normality" frame.

    Full summary, score breakdown and related studies → Original source

  3. 2020-04-29

    Longitudinal neuroimaging biomarkers differ across Alzheimer’s disease phenotypes

    ✓ Peer-reviewed Brain scans and imaging Brain

    Key finding: Principal component analysis identified patterns of variation in baseline and longitudinal measures of tau uptake and volume that were significantly different across phenotypes. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2020-04-29

    Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease

    ✓ Peer-reviewed Prevention trials Neuroscience bulletin

    Key finding: Both are associated with visuospatial malfunctions in Alzheimer's disease (AD). +2 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2020-04-29

    APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline

    ✓ Peer-reviewed Tau biomarkers Nature

    Key finding: Recent studies have suggested that breakdown of the blood-brain barrier (BBB) is an early biomarker of human cognitive dysfunction 7 , including the early clinical stages of Alzheimer's disease 5,8-10 . +1 more finding

    Full summary, score breakdown and related studies → Original source

  6. 2020-04-29

    Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease

    ✓ Peer-reviewed Long-term cohort studies Neurobiology of aging

    Key finding: However, these variants only explain part of the heritability of Alzheimer's disease (AD). +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2020-04-29

    The Effect of a Virtual Reality-Based Intervention Program on Cognition in Older Adults with Mild Cognitive Impairment: A Randomized Control Trial

    ✓ Peer-reviewed Cognitive tests and assessment Journal of clinical medicine

    Key finding: In a randomized controlled trial, we enrolled 68 individuals with mild cognitive impairment (MCI). +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2020-04-28

    Synaptic plasticity in Alzheimer's disease and healthy aging

    ✓ Peer-reviewed Disease mechanisms Reviews in the neurosciences

    Key finding: These types of cellular memory and learning models include specific stimulation protocols that generate a long-term strengthening of the synapses, called long-term potentiation, or a weakening of the said long-term synapses, called long-term depression. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2020-04-28

    Green spaces, dementia and a meaningful life in the community: A mixed studies review

    ✓ Peer-reviewed Risk factors Health & place

    Key finding: These findings provide conceptual links between psychosocial understandings of the relationships between nature and wellbeing with rights-based dementia discourses. +1 more finding

    Full summary, score breakdown and related studies → Original source

  10. 2020-04-28

    Could metformin be therapeutically useful in Huntington's disease?

    ✓ Peer-reviewed Drug development Reviews in the neurosciences

    Key finding: Emerging evidence suggest that dimethylbiguanide (metformin), a first-line drug for type 2 diabetes mellitus, could be neuroprotective in a range of brain pathologies, which include neurodegenerative diseases and brain injury. +1 more finding

    Full summary, score breakdown and related studies → Original source

  11. 2020-04-28

    Lipid and Lipoprotein Metabolism in Microglia

    ✓ Peer-reviewed TREM2 and immune genetics Frontiers in physiology

    Key finding: Microglial activation is a salient feature of neuroinflammation involving a dynamic process that generates multitudinous microglial phenotypes that can respond to a variety of situational cues in the central nervous system. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2020-04-28

    Digital Mental Health Tools for Caregivers of Older Adults-A Scoping Review

    ✓ Peer-reviewed Digital health tools Frontiers in public health

    Key finding: Caregivers reported that digital mental health tools have an overall positive role in their health. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2020-04-28

    Accuracy of Biomarker Testing for Neuropathologically Defined Alzheimer Disease in Older Adults With Dementia

    ✓ Peer-reviewed Biomarkers Annals of internal medicine

    Key finding: In methodologically heterogeneous studies of uncertain applicability to typical clinical settings, amyloid PET, 18 F-FDG PET, and MRI were highly sensitive for neuropathologic AD.

    Full summary, score breakdown and related studies → Original source

  14. 2020-04-27

    Disease-associated astrocytes in Alzheimer's disease and aging

    ✓ Peer-reviewed Genetics Nature neuroscience

    Key finding: The role of non-neuronal cells in Alzheimer's disease progression has not been fully elucidated. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2020-04-27

    Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies

    ✓ Peer-reviewed Getting a diagnosis Acta neuropathologica

    Key finding: The results show that our RT-QuIC assay can accurately detect α-synuclein seeding activity across the spectrum of Lewy Body (LB)-related disorders (LBD), including DLB, PD, iRBD, and PAF, with an overall sensitivity of 95.3%. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2020-04-25

    Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis

    ✓ Peer-reviewed Disease mechanisms Experimental neurology

    Key finding: A fuller perspective of mitochondrial dysfunction in AD, and its relation to protein aggregation, could enhance our overall understanding of this disease.

    Full summary, score breakdown and related studies → Original source

  17. 2020-04-24

    Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease

    ✓ Peer-reviewed Drug development AMB Express

    Key finding: Our results indicated that oral administration of MG136-pMG36e-GLP-1 significantly reduced lipopolysaccharide (LPS)-induced memory impairment and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced motor dysfunction through the toll-like receptor4 (TLR4)/nuclear factor-kappa B (NFκB) and protein kinase B (AKT)/Glycogen synthase kinase-3β (GSK3β) signaling pathway. +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →