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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 11,801–11,825 of 27,380 studies, newest first · page 473 of 1096.

March 2020 25

  1. 2020-03-23

    Development of disease-modifying drugs for frontotemporal dementia spectrum disorders

    ✓ Peer-reviewed Clinical safety Nature reviews. Neurology

    Key finding: The various FTD spectrum disorders are associated with brain accumulation of different proteins: tau, the transactive response DNA binding protein of 43 kDa (TDP43), or fused in sarcoma (FUS) protein, Ewing sarcoma protein and TATA-binding protein-associated factor 15 (TAF15) (collectively known as FET proteins). +2 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2020-03-20

    Advance care planning for people living with dementia: An umbrella review of effectiveness and experiences

    ✓ Peer-reviewed End-of-life care International journal of nursing studies

    Key finding: Advance care planning is acceptable for people with dementia and their carers and is associated with improved outcomes. +2 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2020-03-20

    Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways

    ✓ Peer-reviewed TREM2 and immune genetics Neuron

    Key finding: Here, we present comprehensive datasets and analyses of brain transcriptomes and blood metabolomes from human apoE2-, apoE3-, and apoE4-targeted replacement mice across young, middle, and old ages with both sexes. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2020-03-19

    Gut microbiota and pro/prebiotics in Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Aging

    Key finding: Recently, in addition to the strongly developing ischemic etiology of Alzheimer's disease, it is suggested that the gut microbiota may also participate in the development of this disease.

    Full summary, score breakdown and related studies → Original source

  5. 2020-03-19

    Increased risk of dementia among patients with overactive bladder treated with an anticholinergic medication compared to a beta-3 agonist: a population-based cohort study

    ✓ Peer-reviewed Digital health tools BJU international

    Key finding: The use of anticholinergic medications among patients with OAB was associated with an increased risk of new-onset dementia compared to beta-3 agonist users. +4 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2020-03-19

    Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase

    ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy

    Key finding: High levels of Aβ42 and tau in both young controls and DS suggest these proteins are produced by normal physiological processes, whereas the changes seen in later life are consistent with emergence of pathological alterations. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2020-03-19

    Prevention of dementia in an ageing world: Evidence and biological rationale

    ✓ Peer-reviewed Inflammation and the immune system Ageing research reviews

    Key finding: In this narrative review, we provide a summary of the scientific evidence concerning dementia prevention, with a focus on the following three strategies: 1) Targeting the body to protect the brain, including prevention and treatment of cardiovascular morbidity; 2) Compensatory interventions to counteract brain ageing, including education and life-long engagement in cognitively and socially stimulating activities; and 3) Lifespan health promotion, such as a physically active lifestyle, smoking cessation, and a healthy and balanced diet. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2020-03-18

    Interplay between Socioeconomic Markers and Polygenic Predisposition on Timing of Dementia Diagnosis

    ✓ Peer-reviewed Genetics Journal of the American Geriatrics Society

    Key finding: A one standard deviation increase in AD-PGS was associated with an accelerated time to dementia diagnosis by 4.8 months. +4 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2020-03-18

    The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease

    ✓ Peer-reviewed Disease mechanisms Frontiers in cellular and infection microbiology

    Key finding: Moreover, significant quantitative and qualitative changes of gut microbiome have been reported in patients with Alzheimer's disease.

    Full summary, score breakdown and related studies → Original source

  10. 2020-03-18

    Diet, inflammation and the gut microbiome: Mechanisms for obesity-associated cognitive impairment

    ✓ Peer-reviewed Prevention and risk Biochimica et biophysica acta. Molecular basis of disease

    Key finding: Poor diet and obesity are associated with cognitive impairment throughout adulthood, and increased dementia risk in aging.

    Full summary, score breakdown and related studies → Original source

  11. 2020-03-18

    Impact of Hypertension on Cognitive Decline and Dementia

    ✓ Peer-reviewed Treatments Annals of geriatric medicine and research

    Key finding: Hypertension is associated with vascular dementia but may also affect the manifestations of Alzheimer disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2020-03-17

    GSK3β and Tau Protein in Alzheimer's Disease and Epilepsy

    ✓ Peer-reviewed Disease mechanisms Frontiers in cellular neuroscience

    Key finding: Although the pathophysiology of seizures in AD is not completely understood, it could represent the result of several molecular mechanisms linked to amyloid beta-peptide (Aβ) accumulation and the hyperphosphorylation of tau protein, which may induce an imbalance in the release and recapture of excitatory and inhibitory neurotransmitters, structural alterations of the neuronal cytoskeleton, synaptic loss, and neuroinflammation. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2020-03-17

    Systematic review of gene expression studies in people with Lewy body dementia

    ✓ Peer-reviewed Inflammation and the immune system Acta neuropsychiatrica

    Key finding: We screened 3,809 articles and identified 31 eligible studies. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2020-03-16

    Blood Pressure Control and Dementia Risk in Midlife Patients With Atrial Fibrillation

    ✓ Peer-reviewed Risk factors Hypertension (Dallas, Tex. : 1979)

    Key finding: Atrial fibrillation (AF) is associated with increased risk of cognitive impairment and dementia, even with no overt stroke. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2020-03-16

    Effective differentiation of mild cognitive impairment by functional brain graph analysis and computerized testing

    ✓ Peer-reviewed Cognitive tests and assessment PloS one

    Key finding: Community-dwelling African American elders are twice as likely to develop mild cognitive impairment (MCI) or Alzheimer's disease and related dementias than older white Americans and therefore represent a significant at-risk group in need of early monitoring. +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2020-03-16

    Brain insulin resistance: role in neurodegenerative disease and potential for targeting

    ✓ Peer-reviewed Drug development Expert opinion on investigational drugs

    Key finding: This review evaluates the novel strategy of treating Alzheimer's and Parkinson's disease (AD and PD) withdrugs that initially have been developed to treat type 2 diabetes. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2020-03-14

    Potential Role of Venular Amyloid in Alzheimer's Disease Pathogenesis

    ✓ Peer-reviewed Vascular contributions International journal of molecular sciences

    Key finding: Insurmountable evidence has demonstrated a strong association between Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA), along with various other cerebrovascular diseases. +1 more finding

    Full summary, score breakdown and related studies → Original source

  18. 2020-03-14

    Potential Therapeutic Approaches for Cerebral Amyloid Angiopathy and Alzheimer's Disease

    ✓ Peer-reviewed TREM2 and immune genetics International journal of molecular sciences

    Key finding: This work has revealed potential therapeutic targets, including Aβ drainage pathways, Aβ aggregation, oxidative stress, and neuroinflammation. +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2020-03-13

    Pathways Connecting Late-Life Depression and Dementia

    ✓ Peer-reviewed Treatments Frontiers in pharmacology

    Key finding: Late-life depression is associated with significant cognitive impairment. +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2020-03-13

    Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease

    ✓ Peer-reviewed Biomarkers Nature communications

    Key finding: These results emphasize the importance of reducing the Aβ42/40 ratio in AD therapy.

    Full summary, score breakdown and related studies → Original source

  21. 2020-03-13

    The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer's Disease and Other Neurodegenerative Disorders

    ✓ Peer-reviewed Risk genes beyond APOE Neurochemical research

    Key finding: These receptors after heterodimerization with retinoid X receptor (RXR) bind in promotor of target genes to PPAR response elements (PPREs) and act as a potent transcription factors. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2020-03-12

    Discovering the Italian phenotype of cerebral amyloid angiopathy (CAA): the SENECA project

    ✓ Peer-reviewed Vascular contributions Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    Key finding: Cerebral amyloid angiopathy (CAA) is one of the major types of cerebral small vessel disease, and a leading cause of spontaneous intracerebral hemorrhage and cognitive decline in elderly patients. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2020-03-12

    Fingerprinting Alzheimer's Disease by 1H Nuclear Magnetic Resonance Spectroscopy of Cerebrospinal Fluid

    ✓ Peer-reviewed Tau biomarkers Journal of proteome research

    Key finding: Metabolomic fingerprinting in the Dutch cohort provides a significant discrimination (86.1% accuracy) between ADdem and non-AD. +2 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2020-03-12

    PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment

    ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica

    Key finding: To explore the protective nature of this variant, we employed latent process linear mixed models to examine the association of p.P522R with longitudinal cognitive decline in 3595 MCI patients, and in 10,097 individuals from population-based studies. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2020-03-11

    APOEε4 potentiates the relationship between amyloid-β and tau pathologies

    ✓ Peer-reviewed Brain scans and imaging Molecular psychiatry

    Key finding: APOEε4 is the most well-established genetic risk factor for sporadic Alzheimer's disease and is associated with cerebral amyloid-β. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →