Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 17,926–17,950 of 27,380 studies, newest first · page 718 of 1096.
April 2014 15
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2014-04-01
Frontotemporal lobar degeneration: a clinical approach
36/100 ✓ Peer-reviewed Drug development Seminars in neurology
Key finding: In this review, the authors outline a clinical approach to frontotemporal lobar degeneration (FTLD), a term coined to describe a pathology associated with atrophy of the frontal and temporal lobes commonly seen with abnormal protein aggregates. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-01
Optimizing person-centered transitions in the dementia journey: a comparison of national dementia strategies
36/100 ✓ Peer-reviewed End-of-life care Health affairs (Project Hope)
Key finding: Adopting a person-centered perspective, we found that most or all of the national strategies adequately address earlier transitions in the journey, but fewer strategies address the later transitions.
Full summary, score breakdown and related studies → Original source
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2014-04-01
Vital conversations with family in the nursing home: preparation for end-stage dementia care
69/100 ✓ Peer-reviewed End-of-life care Journal of social work in end-of-life & palliative care
Key finding: Family members of persons with advanced dementia may be asked to make complex treatment decisions without having adequate knowledge regarding the risks and benefits.
Full summary, score breakdown and related studies → Original source
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2014-04-01
Advance directives and nursing home stays associated with less aggressive end-of-life care for patients with severe dementia
36/100 ✓ Peer-reviewed End-of-life care Health affairs (Project Hope)
Key finding: We found that cognitive impairment is common among older adults approaching the end of life, whether they live in the community or in a nursing home, and that nearly 30 percent of patients with severe dementia remained in the community until death. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-01
Factors associated with increased caregivers' burden in several cognitive stages of Alzheimer's disease
45/100 ✓ Peer-reviewed Clinical safety Geriatrics & gerontology international
Key finding: Multiple factors including BPSD, impaired life function and geriatric syndrome were cognitive stage-dependently associated with CB. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-01
[Insulin resistance and cognitive function]
29/100 ✓ Peer-reviewed Drug development Nihon rinsho. Japanese journal of clinical medicine
Key finding: Insulin resistance is identified as a pathogenic mechanism of impaired cognitive dysfunction. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-01
[Biomarkers in Alzheimer's disease]
27/100 ✓ Peer-reviewed Tau biomarkers Revista de neurologia
Key finding: Three CSF biomarkers, Aß42, total tau, and phosphorylated tau, reflect the core pathological features of AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-01
Diagnostic performance of cerebrospinal fluid total tau and phosphorylated tau in Creutzfeldt-Jakob disease: results from the Swedish Mortality Registry
64/100 ✓ Peer-reviewed Tau biomarkers JAMA neurology
Key finding: Identifying a clinical distinction between the invariably lethal prion disease Creutzfeldt-Jakob disease (CJD) and nonprion rapidly progressive dementias is important and sometimes difficult; thus, reliable tools for diagnosis are in great demand. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-01
The genetics of Alzheimer's disease
46/100 ✓ Peer-reviewed TREM2 and immune genetics Clinical interventions in aging
Key finding: Three main genes are involved in early onset AD: amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2). +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-01
TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis
56/100 ✓ Peer-reviewed Risk genes beyond APOE JAMA neurology
Key finding: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which microglia play a significant and active role. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-01
Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis
55/100 ✓ Peer-reviewed Risk genes beyond APOE JAMA neurology
Key finding: The AD brain is characterized microscopically by the combined presence of 2 classes of abnormal structures, extracellular amyloid plaques and intraneuronal neurofibrillary tangles, both of which comprise highly insoluble, densely packed filaments. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-01
Pharmacological treatment of Parkinson disease: a review
59/100 ✓ Peer-reviewed Risk factors JAMA
Key finding: Although levodopa is the most effective medication available for treating the motor symptoms of Parkinson disease, in certain instances (eg, mild symptoms, tremor as the only or most prominent symptom, aged Conclusions and relevance Strong evidence supports using levodopa and dopamine agonists for motor symptoms at all stages of Parkinson disease.
Full summary, score breakdown and related studies → Original source
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2014-04-01
Pseudo-dementia: A neuropsychological review
36/100 ✓ Peer-reviewed Digital health tools Annals of Indian Academy of Neurology
Key finding: Thus, it is important to have a detailed knowledge of the cognitive or neuropsychological deficits in this condition. +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-04-01
Dementia prevalence and care in assisted living
45/100 ✓ Peer-reviewed Disparities Health affairs (Project Hope)
Key finding: Estimates derived from national data indicate that seven out of ten residents in these residences have some form of cognitive impairment, with 29 percent having mild impairment, 23 percent moderate impairment, and 19 percent severe impairment.
Full summary, score breakdown and related studies → Original source
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2014-04-01
Synergistic effects of ischemia and β-amyloid burden on cognitive decline in patients with subcortical vascular mild cognitive impairment
55/100 ✓ Peer-reviewed Brain scans and imaging JAMA psychiatry
Key finding: Most patients with svMCI do not exhibit substantial amyloid burden, and CVD does not increase β-amyloid burden as measured by amyloid imaging. +4 more findings
Full summary, score breakdown and related studies → Original source
March 2014 10
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2014-03-31
Cognitive functioning and late-life depression
38/100 ✓ Peer-reviewed Risk factors Journal of the International Neuropsychological Society : JINS
Key finding: This brief report provides an introduction to the topic of cognitive functioning in late-life depression (LLD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-31
Why looking at the whole hippocampus is not enough-a critical role for anteroposterior axis, subfield and activation analyses to enhance predictive value of hippocampal changes for Alzheimer's disease diagnosis
55/100 ✓ Peer-reviewed Hippocampus size on brain scans Frontiers in cellular neuroscience
Key finding: Finally, we indicate that apart from hippocampal subfield volumetry, the characteristic pattern of hippocampal hyperactivation associated with seizures and neurogenesis changes is another promising candidate for an early AD biomarker that could become also a target for early interventions.
Full summary, score breakdown and related studies → Original source
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2014-03-31
Review of brief cognitive tests for patients with suspected dementia
49/100 ✓ Peer-reviewed Cognitive tests and assessment International psychogeriatrics
Key finding: As the population ages, it is increasingly important to use effective short cognitive tests for suspected dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-31
Benefit-finding intervention for Alzheimer caregivers: conceptual framework, implementation issues, and preliminary efficacy
59/100 ✓ Peer-reviewed Treatments The Gerontologist
Key finding: Controlling for pretest, the benefit-finding group had lower depression than the psychoeducation group at post-test, despite the fact that some caregivers found benefit-finding challenging. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-30
Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis
58/100 ✓ Peer-reviewed Lewy body dementia Nature neuroscience
Key finding: MATR3 is an RNA- and DNA-binding protein that interacts with TDP-43, a disease protein linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-27
Differential effects of angiotensin II receptor blockers on Aβ generation
38/100 ✓ Peer-reviewed Biomarkers Neuroscience letters
Key finding: Here, we studied the effect of ARBs on Aβ generation and found that telmisartan significantly increased Aβ40 and Aβ42 generation, but decreased the Aβ42/Aβ40 ratio. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-27
Epidemiology and outcomes in community-acquired versus hospital-acquired AKI
52/100 ✓ Peer-reviewed Risk factors Clinical journal of the American Society of Nephrology : CJASN
Key finding: The incidence of CA-AKI among all hospital admissions was 4.3% compared with an incidence of 2.1% of HA-AKI, giving an overall AKI incidence of 6.4%. +1 more finding
Full summary, score breakdown and related studies → Original source
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2014-03-26
Reversal of English trend towards hospital death in dementia: a population-based study of place of death and associated individual and regional factors, 2001–2010
46/100 ✓ Peer-reviewed Health systems and care delivery BMC Neurology
Key finding: Most people died in care homes (55.3%) or hospitals (39.6%). +4 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-25
Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease
43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Free radical biology & medicine
Key finding: We suggest that a group of identified proteins followed a specific pattern of oxidation in DS vs young controls, probably indicating characteristic features of the DS phenotype; a second group of identified proteins showed increased oxidation in DS/AD vs DS, thus possibly playing a role in the development of AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2014-03-25
Multivariate models of subjective caregiver burden in dementia: a systematic review
63/100 ✓ Peer-reviewed Caregiving Ageing research reviews
Key finding: We found 32 studies with burden models and 24 depression and mental health models. +1 more finding
Full summary, score breakdown and related studies → Original source
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