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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 10,426–10,450 of 27,380 studies, newest first · page 418 of 1096.

March 2021 25

  1. 2021-03-12

    NOTCH3 variants are more common than expected in the general population and associated with stroke and vascular dementia: an analysis of 200 000 participants

    ✓ Peer-reviewed Long-term cohort studies Journal of neurology, neurosurgery, and psychiatry

    Key finding: Cysteine-altering NOTCH3 variants identical to those causing the rare monogenic form of stroke, CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), have been reported more common than expected in the general population, but their clinical significance and contribution to stroke and dementia risk in the community remain unclear. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2021-03-11

    Computational Approaches for Supporting Combination Therapy in the Post-Aducanumab Era in Alzheimer’s Disease

    ✓ Peer-reviewed Treatments Journal of Alzheimer's Disease Reports

    Key finding: Such models simulate effects on action potential dynamics of anatomically informed neuronal circuits driving functional clinical readouts. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2021-03-11

    Activity Engagement and Cognitive Performance Amongst Older Adults

    ✓ Peer-reviewed Risk factors Frontiers in psychology

    Key finding: Research supporting cognitive reserve theory suggests that engaging in a variety of cognitive, social, and physical activities may serve as protective factors against age-related changes in mental functioning, especially if the activities are cognitively engaging. +2 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2021-03-11

    The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science

    ✓ Peer-reviewed Clinical safety Frontiers in neurology

    Key finding: Here we introduce a research and networking initiative designed to tackle these ensuing hurdles, the Multi-partner consortium to expand dementia research in Latin America (ReDLat). +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2021-03-11

    Impact of the COVID-19 pandemic on statistical design and analysis plans for multidomain intervention clinical trials: Experience from World-Wide FINGERS

    ✓ Peer-reviewed Prevention trials Alzheimer's & dementia (New York, N. Y.)

    Key finding: Robust approaches to study design and analysis are critical to negotiate issues related to the intervention.

    Full summary, score breakdown and related studies → Original source

  6. 2021-03-11

    A population-based study of head injury, cognitive function and pathological markers

    ✓ Peer-reviewed Biomarkers Annals of clinical and translational neurology

    Key finding: Having a LOC HI aged 50's and younger was linked with lower later-life cognitive function at age ~70 than expected. +1 more finding

    Full summary, score breakdown and related studies → Original source

  7. 2021-03-10

    A critical realist evaluation of advance care planning in care homes

    ✓ Peer-reviewed Health systems and care delivery Journal of advanced nursing

    Key finding: Participants comprised of registered nurses (N = 4), care assistants (N = 8), bereaved relatives (N = 7), and domiciliary staff (N = 3). +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-03-10

    Neurodegenerative Disease and the NLRP3 Inflammasome

    ✓ Peer-reviewed Inflammation and the immune system Frontiers in pharmacology

    Key finding: The prevalence of neurodegenerative disease has increased significantly in recent years, and with a rapidly aging global population, this trend is expected to continue.

    Full summary, score breakdown and related studies → Original source

  9. 2021-03-10

    Insomnia in neurological diseases

    ✓ Peer-reviewed Risk factors Neurological research and practice

    Key finding: Insomnia is a frequent precursor of MS symptoms by up to 10 years. +4 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2021-03-10

    The Behavioral Effects of Combination Therapy of Memantine and Acetylcholinesterase Inhibitors Compared with Acetylcholinesterase Inhibitors Alone in Patients with Moderate Alzheimer's Dementia: A Double-Blind Randomized Placebo-Controlled Trial

    ✓ Peer-reviewed Clinical trials Psychiatry investigation

    Key finding: There were no significant differences in age, sex, or education between AChEIs alone and combination groups. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2021-03-10

    Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's research & therapy

    Key finding: These data point to significant reductions in KLC1 in AD and AD-DS. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-03-09

    The sTREM2 Concentrations in the Blood: A Marker of Neurodegeneration?

    ✓ Peer-reviewed TREM2 and immune genetics Frontiers in molecular biosciences

    Key finding: It is noteworthy that, while CSF sTREM2 levels have been extensively studied, few studies have investigated sTREM2 in blood producing conflicting results. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2021-03-09

    Transformer-based deep neural network language models for Alzheimer's disease risk assessment from targeted speech

    ✓ Peer-reviewed Digital health tools BMC medical informatics and decision making

    Key finding: Using pre-trained language models can improve AD prediction. +1 more finding

    Full summary, score breakdown and related studies → Original source

  14. 2021-03-09

    Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease

    ✓ Peer-reviewed Digital health tools International journal of molecular sciences

    Key finding: Our results revealed machine learning with novel biomarkers and multiple variables may increase the sensitivity and specificity in diagnosis of AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2021-03-09

    Head injury and 25-year risk of dementia

    ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association

    Key finding: Head injury was associated with risk of dementia (hazard ratio [HR] = 1.44, 95% confidence interval [CI] = 1.3-1.57), with evidence of dose-response (1 head injury: HR = 1.25, 95% CI = 1.13-1.39, 2+ head injuries: HR = 2.14, 95% CI = 1.86-2.46). +2 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-03-08

    Social isolation and loneliness in old age: Exploring their role in mental and physical health

    ✓ Peer-reviewed Risk factors Psychiatrike = Psychiatriki

    Key finding: Social isolation and loneliness are two distinctive concepts that have been identified as risk factors for wellbeing, health and everyday functioning in profound ways. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2021-03-08

    Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease

    ✓ Peer-reviewed Risk genes beyond APOE Molecular neurodegeneration

    Key finding: Emerging evidence indicates that impaired mitophagy-mediated clearance of defective mitochondria is a critical event in Alzheimer's disease (AD) pathogenesis. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-03-08

    The Relationship Between Anxiety and Alzheimer's Disease

    ✓ Peer-reviewed Mild cognitive impairment Journal of Alzheimer's disease reports

    Key finding: Although Alzheimer's disease (AD) is primarily a neurocognitive disorder, it also results in prominent neuropsychiatric symptoms (NPS). +1 more finding

    Full summary, score breakdown and related studies → Original source

  19. 2021-03-06

    Amyloid-β positive individuals with subjective cognitive decline present increased CSF neurofilament light levels that relate to lower hippocampal volume

    ✓ Peer-reviewed Biomarkers Neurobiology of aging

    Key finding: There was a significant interaction between SCD and CSF-Aβ42/40 levels. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2021-03-06

    27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial

    ✓ Peer-reviewed Prevention trials Alzheimer's research & therapy

    Key finding: 27-OH appears to be a marker not only for dementia/AD risk, but also for monitoring the effects of preventive interventions on cholesterol metabolism. +2 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2021-03-06

    Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer's disease

    ✓ Peer-reviewed Disease mechanisms Alzheimer's research & therapy

    Key finding: These data demonstrate the neuroprotective effects of systemic administration of stem cell-derived EVs for remediation of behavioral and molecular AD neuropathologies. +3 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2021-03-05

    Value-Generating Exploratory Trials in Neurodegenerative Dementias

    ✓ Peer-reviewed Clinical trials Neurology

    Key finding: Exploratory trials can establish go/no-go decision points, support proof of concept and dose selection, and terminate drugs that fail to show target engagement with suitable exposure and acceptable safety profiles. +4 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2021-03-05

    Correlation of Frontal Atrophy and CSF Tau Levels With Neuropsychiatric Symptoms in Patients With Cognitive Impairment: A Memory Clinic Experience

    ✓ Peer-reviewed Tau biomarkers Frontiers in aging neuroscience

    Key finding: Delusions, hallucinations, and psychosis cluster were differently distributed among the diagnostic groups (p < 0.05, p < 0.001, and p < 0.05), with LBD patients showing higher scores for hallucinations (vs. +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2021-03-05

    Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology

    ✓ Peer-reviewed TREM2 and immune genetics Neuron

    Key finding: Trem2 deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a prominent feature of pre-diagnosis AD stages. +3 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2021-03-05

    Behavioural and psychological symptoms of dementia in patients with Alzheimer's disease and family caregiver burden: a path analysis

    ✓ Peer-reviewed Caregiving BMC geriatrics

    Key finding: Mean total BPSD score was 17.66 ± 20.67, and the mean score for family caregiver burden was 9.65 ± 11.12.

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →