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Longitudinal neuroimaging biomarkers differ across Alzheimer’s disease phenotypes
Irene Sintini, Jonathan Graff‐Radford, Matthew L. Senjem, Christopher G. Schwarz, Mary M. Machulda, Peter R. Martin, David Thomas Jones, Bradley F. Boeve et al.. Brain, 2020-04-29
Topic: Plasma and spinal-fluid biomarkers
Principal component analysis identified patterns of variation in baseline and longitudinal measures of tau uptake and volume that were significantly different across phenotypes. Our study suggests that optimal longitudinal neuroimaging biomarkers for future clinical treatment trials in Alzheimer's disease are different for MRI and tau-PET and may differ across phenotypes, particularly for MRI.
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APA 7th
Sintini, I., Graff‐Radford, J., Senjem, M. L., Schwarz, C. G., Machulda, M. M., Martin, P. R., et al. (2020). Longitudinal neuroimaging biomarkers differ across Alzheimer’s disease phenotypes. Brain. https://doi.org/10.1093/brain/awaa155
Vancouver
Sintini I, Graff‐Radford J, Senjem ML, Schwarz CG, Machulda MM, Martin PR, et al. Longitudinal neuroimaging biomarkers differ across Alzheimer’s disease phenotypes. Brain. 2020. doi:10.1093/brain/awaa155. PMID: 32572464.
BibTeX
@article{sintini2020-32572464,
author = {Sintini, Irene and Graff‐Radford, Jonathan and Senjem, Matthew L. and Schwarz, Christopher G. and Machulda, Mary M. and Martin, Peter R. and Jones, David Thomas and Boeve, Bradley F. and others},
title = {{Longitudinal neuroimaging biomarkers differ across Alzheimer’s disease phenotypes}},
journal = {Brain},
year = {2020},
doi = {10.1093/brain/awaa155},
pmid = {32572464},
url = {https://doi.org/10.1093/brain/awaa155}
}
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Key findings
- Principal component analysis identified patterns of variation in baseline and longitudinal measures of tau uptake and volume that were significantly different across phenotypes.
- Our study suggests that optimal longitudinal neuroimaging biomarkers for future clinical treatment trials in Alzheimer's disease are different for MRI and tau-PET and may differ across phenotypes, particularly for MRI.
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Study details
- Study designlongitudinal study
- Participants57
- Evidence strengthModerate
How this study scored 67/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 39 of the 58 points we could judge it on, which is 67 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 57 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32572464) |
| Free to read | 2 / 2 | Free to read |
| Points | 39 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 39 of the 58 points we could judge it on is 67 out of 100. |
| Total | 67 / 100 | — |
What each of these 20 components measures, and what this score is not →
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