alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 11,051–11,075 of 27,380 studies, newest first · page 443 of 1096.

October 2020 25

  1. 2020-10-22

    The Impact of COVID-19 Infection and Enforced Prolonged Social Isolation on Neuropsychiatric Symptoms in Older Adults With and Without Dementia: A Review

    ✓ Peer-reviewed Clinical safety Frontiers in psychiatry

    Key finding: Fifteen articles were included: 8 focussed on the psychiatric symptoms caused by the COVID-19 infection and 7 investigated the impact of social isolation on older adults' neuropsychiatric symptoms. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2020-10-22

    Incident Instrumental Activities of Daily Living Difficulty in Older Adults: Which Comes First? Findings From the Advanced Cognitive Training for Independent and Vital Elderly Study

    ✓ Peer-reviewed Prevention trials Frontiers in neurology

    Key finding: A total of 887 (69.5%) participants reported incident difficulty in at least one IADL task category. +4 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2020-10-22

    Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer's disease

    ✓ Peer-reviewed Inflammation and the immune system Life sciences

    Key finding: Gut microbiota communicates with the brain and vice versa through complex bidirectional communication systems - the gut-brain axis, which integrates the peripheral intestinal function with emotional and cognitive brain centers via neuro-immuno-endocrine mediators. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2020-10-22

    Linguistic markers predict onset of Alzheimer's disease

    ✓ Peer-reviewed Long-term cohort studies EClinicalMedicine

    Key finding: The aim of this study is to use classification methods to predict future onset of Alzheimer's disease in cognitively normal subjects through automated linguistic analysis. +3 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2020-10-22

    Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease

    ✓ Peer-reviewed TREM2 and immune genetics Neuron

    Key finding: Many of these approaches have targeted the amyloid cascade, indicating that novel treatment strategies are required. +3 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2020-10-22

    The Psychological Impact of COVID-19 Pandemic and Lockdown on Caregivers of People With Dementia

    ✓ Peer-reviewed Caregiving The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    Key finding: COVID-19 pandemic and the lockdown produced psychological consequences in caregivers of pwD, with an increase of levels of depression. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2020-10-22

    Topographic Distribution of Amyloid-β, Tau, and Atrophy in Patients With Behavioral/Dysexecutive Alzheimer Disease

    ✓ Peer-reviewed Biomarkers Neurology

    Key finding: Our results provide evidence of frontal cortical involvement of tau pathology in behavioral/dysexecutive AD and highlight the need for consensus clinical criteria in this syndrome. +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2020-10-21

    The Association of Advance Care Planning Documentation and End-of-Life Healthcare Use Among Patients With Multimorbidity

    ✓ Peer-reviewed End-of-life care The American journal of hospice & palliative care

    Key finding: ACP documentation >30 days before death was associated with lower odds of in-hospital death for all 4 conditions both in patients with and without multimorbidity. +3 more findings

    Full summary, score breakdown and related studies → Original source

  9. 2020-10-21

    Ganglion Cell Layer Thinning in Alzheimer's Disease

    ✓ Peer-reviewed Brain scans and imaging Medicina (Kaunas, Lithuania)

    Key finding: Despite several differences, previous works found a significant thinning of GC layer in patients with AD and MCI.

    Full summary, score breakdown and related studies → Original source

  10. 2020-10-21

    Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer

    ✓ Peer-reviewed Risk factors International journal of molecular sciences

    Key finding: BDNF is considered an instructive mediator of functional and structural plasticity in the central nervous system (CNS), influencing dendritic spines and, at least in the hippocampus, the adult neurogenesis. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2020-10-21

    Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer's disease

    ✓ Peer-reviewed Tau biomarkers Science advances

    Key finding: Overall, these results are a promising step toward a network-based biomarker tool for AD clinical applications.

    Full summary, score breakdown and related studies → Original source

  12. 2020-10-21

    Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model

    ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation

    Key finding: Neuropathic pain (NeuP) is a chronic and challenging clinical problem, with little effective treatment. +3 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2020-10-19

    Long-term effects of PM 2·5 on neurological disorders in the American Medicare population: a longitudinal cohort study

    ✓ Peer-reviewed Risk factors The Lancet. Planetary health

    Key finding: Between Jan 1, 2000, and Dec 31, 2016, of 63 038 019 individuals who were aged 65 years or older during the study period, we identified 1·0 million cases of Parkinson's disease and 3·4 million cases of Alzheimer's disease and related dementias based on primary and secondary diagnosis billing codes.

    Full summary, score breakdown and related studies → Original source

  14. 2020-10-19

    Efficacy of non-invasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis

    ✓ Peer-reviewed Vascular contributions Psychological medicine

    Key finding: Our results revealed that both TMS and tDCS elicit a small trans-diagnostic effect on working memory, tDCS also improved attention/vigilance across diagnoses. +4 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2020-10-19

    Elderly Perception of Distance to the Grocery Store as a Reason for Feeling Food Insecurity—Can Food Policy Limit This?

    ✓ Peer-reviewed Risk factors Nutrients

    Key finding: Reduced food consumption due to the distance from the place of sale, including of fish (24.8%), some fruits (18.9%) and vegetables (15.4%) and beef (17.3%), may contribute to the deterioration of the diet and, as a result, health conditions.

    Full summary, score breakdown and related studies → Original source

  16. 2020-10-19

    EEG microstate complexity for aiding early diagnosis of Alzheimer's disease

    ✓ Peer-reviewed Mild cognitive impairment Scientific reports

    Key finding: The microstate associated with the frontoparietal working-memory/attention network was altered in AD due to parietal inactivation. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2020-10-19

    Machine Learning to Develop and Internally Validate a Predictive Model for Post-operative Delirium in a Prospective, Observational Clinical Cohort Study of Older Surgical Patients

    ✓ Peer-reviewed Digital health tools Journal of general internal medicine

    Key finding: We developed machine learning prediction models for post-operative delirium that performed better than chance and are comparable with traditional stepwise logistic regression.

    Full summary, score breakdown and related studies → Original source

  18. 2020-10-19

    The impact of a multi-domain intervention on cerebral glucose metabolism: analysis from the randomized ancillary FDG PET MAPT trial

    ✓ Peer-reviewed Treatments Alzheimer's research & therapy

    Key finding: MI failed to show an effect on metabolism in FDG-based AD biomarker, but exploratory analysis suggested positive effect on limbic system metabolism. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2020-10-19

    APOE2 is associated with longevity independent of Alzheimer's disease

    ✓ Peer-reviewed Genetics eLife

    Key finding: Human data (n=24,661) showed APOE2's survival benefit persisted after adjusting for cognitive status, Alzheimer's diagnosis, and cardiovascular factors +3 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2020-10-18

    High-resolution functional connectivity of the default mode network in young adults with down syndrome

    ✓ Peer-reviewed Brain scans and imaging Brain imaging and behavior

    Key finding: Studies of resting-state functional connectivity MRI in Alzheimer's disease suggest that disease stage plays a role in functional changes of the default mode network.

    Full summary, score breakdown and related studies → Original source

  21. 2020-10-16

    Black-White Disparities in Moves to Assisted Living and Nursing Homes Among Older Medicare Beneficiaries

    ✓ Peer-reviewed Health systems and care delivery The journals of gerontology. Series B, Psychological sciences and social sciences

    Key finding: Black older adults are less likely to move to assisted living and are more likely to move to a nursing home compared to white older adults. +2 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2020-10-16

    Degradation and Transmission of Tau by Autophagic-Endolysosomal Networks and Potential Therapeutic Targets for Tauopathy

    ✓ Peer-reviewed Disease mechanisms Frontiers in molecular neuroscience

    Key finding: Moreover, several AD risk genes (e.g., PICALM , GRN , and BIN1 ) have been associated with dysregulation of AELN in the late-onset sporadic AD. +1 more finding

    Full summary, score breakdown and related studies → Original source

  23. 2020-10-16

    TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice

    ✓ Peer-reviewed TREM2 and immune genetics Aging

    Key finding: However, the TREM2 induced anti-inflammatory mechanism is still not well known. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2020-10-16

    Functional connectivity of white matter as a biomarker of cognitive decline in Alzheimer's disease

    ✓ Peer-reviewed Digital health tools PloS one

    Key finding: The white matter FC decreased in late MCI and AD dementia patients compared to CN participants, and this decrease was correlated with cognitive measures. +4 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2020-10-15

    Higher Dementia Incidence in Older Adults with Poor Visual Acuity

    ✓ Peer-reviewed Risk factors The journals of gerontology. Series A, Biological sciences and medical sciences

    Key finding: Over 68,904 person-years of follow-up, 1,349 participants developed dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →