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67/100

✓ Peer-reviewed alzhub usefulness score 67 out of 100. Genetics

Topic: Amyloid, tau and blood-test diagnosis

Objective To examine the demographic (age, sex, and educational level), genetic (APOE-ε4 status), and neuroimaging (white matter hyperintensities and cortical thickness) factors associated with interindividual differences in brain and cognitive resilience to tau positron emission tomography (PET) load and to changes in global cognition over time. Results A total of 260 participants (145 [55.8%] female; mean [SD] age, 69.2 [9.5] years; mean [SD] MMSE score, 21.9 [5.5]) were included in the study. Higher educational level (standardized β = 0.23, P Conclusions and relevance Results of this study suggest that women and young patients with AD have relative preservation of brain structure when exposed to neocortical pathological tau.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Ossenkoppele, R., Lyoo, C. H., Jester-Broms, J., Sudre, C. H., Cho, H., Ryu, Y. H., et al. (2020). Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease. JAMA neurology. https://doi.org/10.1001/jamaneurol.2019.5154

Vancouver

Ossenkoppele R, Lyoo CH, Jester-Broms J, Sudre CH, Cho H, Ryu YH, et al. Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease. JAMA neurology. 2020. doi:10.1001/jamaneurol.2019.5154. PMID: 32091549.

BibTeX

@article{ossenkoppele2020-32091549,
  author  = {Ossenkoppele, R. and Lyoo, C. H. and Jester-Broms, J. and Sudre, C. H. and Cho, H. and Ryu, Y. H. and Choi, J. Y. and Smith, R. and others},
  title   = {{Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2019.5154},
  pmid    = {32091549},
  url     = {https://doi.org/10.1001/jamaneurol.2019.5154}
}

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Key findings

Objective To examine the demographic (age, sex, and educational level), genetic (APOE-ε4 status), and neuroimaging (white matter hyperintensities and cortical thickness) factors associated with interindividual differences in brain and cognitive resilience to tau positron emission tomography (PET) load and to changes in global cognition over time.
Results A total of 260 participants (145 [55.8%] female; mean [SD] age, 69.2 [9.5] years; mean [SD] MMSE score, 21.9 [5.5]) were included in the study.
Higher educational level (standardized β = 0.23, P Conclusions and relevance Results of this study suggest that women and young patients with AD have relative preservation of brain structure when exposed to neocortical pathological tau.

Why it matters

Among 260 people with Alzheimer's disease, higher education was associated with relative preservation of brain structure when exposed to tau, and women and younger patients also showed relative preservation. This is about factors linked to resilience to tau, not about a treatment or cure.

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Study details

Study designcross-sectional
Participants260
Effect size55.8%
Evidence strengthModerate

How this study scored 67/100

Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	4 / 12	A snapshot of people at one point in time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2020 — within 10 year(s) of the newest study here
Sample size	2 / 4	260 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 161 times (OpenAlex, 2026-10-10)
Citations per year	4 / 5	20.1 citations a year over 8 year(s) since 2020
Impact for its field and year	4 / 6	Cited 13.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 15 other studies in this library
Still being cited	3 / 4	Cited 80 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Oskar Hansson: h-index 148 (OpenAlex, whole career)
Institution's track record	2 / 3	University College London: institution h-index 2,029 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 13 institution(s) in 5 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 32091549)
Free to read	0 / 2	Behind a paywall — scores zero
Total	67 / 100	—

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