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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 11,926–11,950 of 27,380 studies, newest first · page 478 of 1096.

February 2020 22

  1. 2020-02-04

    Consequences of physical inactivity in older adults: A systematic review of reviews and meta-analyses

    ✓ Peer-reviewed Clinical safety Scandinavian journal of medicine & science in sports

    Key finding: This review of reviews provides a comprehensive and systematic overview of epidemiological evidence from previously conducted research to assess the associations of physical activity with physical and mental health outcomes in older adults.

    Full summary, score breakdown and related studies → Original source

  2. 2020-02-04

    [Strategies to prevent age-related cognitive decline]

    ✓ Peer-reviewed Drug development Deutsche medizinische Wochenschrift (1946)

    Key finding: If on one hand the achievement or maintenance of a healthy lifestyle should be a medical priority, the early recognition of cognitive disturbances is mandatory. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2020-02-04

    Sensing Technology to Monitor Behavioral and Psychological Symptoms and to Assess Treatment Response in People With Dementia. A Systematic Review

    ✓ Peer-reviewed Digital health tools Frontiers in pharmacology

    Key finding: Targeted clinical application of specific technologies is poised to revolutionize precision care in dementia as these technologies may be used both by patients and caregivers, and at a systems level to provide safe and effective care. +1 more finding

    Full summary, score breakdown and related studies → Original source

  4. 2020-02-04

    Physical exercise in the prevention and treatment of Alzheimer's disease

    ✓ Peer-reviewed Prevention and risk Journal of sport and health science

    Key finding: Among the risk factors associated with AD is a low level of physical activity.

    Full summary, score breakdown and related studies → Original source

  5. 2020-02-03

    Foreign language learning in older age does not improve memory or intelligence: Evidence from a randomized controlled study

    ✓ Peer-reviewed Prevention trials Psychology and aging

    Key finding: We place this in the context of the cognitive training and engagement literature and conclude that while foreign language learning may expand the behavioral repertoire, it does little to improve cognitive processing abilities.

    Full summary, score breakdown and related studies → Original source

  6. 2020-02-03

    Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion

    ✓ Peer-reviewed Inflammation and the immune system Theranostics

    Key finding: Mitochondrial dysfunction and oxidative stress occur in vascular dementia (VaD), but the specific molecular mechanism regulating these events remains unclear. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2020-02-03

    Intermediate flortaucipir uptake is associated with Aβ-PET and CSF tau in asymptomatic adults

    ✓ Peer-reviewed Tau biomarkers Neurology

    Key finding: One-hundred nineteen individuals with a family history of AD (Presymptomatic Evaluation of Experimental or Novel Treatments of Alzheimer's Disease [PREVENT-AD] cohort, mean age 67 ± 5 years) underwent tau-PET ([ 18 F]FTP), β-amyloid (Aβ)-PET ([ 18 F]NAV4694 [NAV]), and cognitive assessment. +3 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2020-02-03

    Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study

    ✓ Peer-reviewed Prevention and risk Nature communications

    Key finding: Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer's dementia, while the APOE2 allele is associated with a lower risk of Alzheimer's dementia, it is not yet known whether APOE2 homozygotes have a particularly low risk. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2020-02-02

    Long-term study finds social contact reduces the risk of dementia

    ✓ Peer-reviewed Health systems and care delivery Nursing and Residential Care

    Key finding: However, research has revealed that socialisation has an important role to play.

    Full summary, score breakdown and related studies → Original source

  10. 2020-02-01

    Diagnosis and Treatment of Parkinson Disease: A Review

    ✓ Peer-reviewed Mild cognitive impairment JAMA

    Key finding: Individuals experiencing complications, such as worsening symptoms and functional impairment when a medication dose wears off ("off periods"), medication-resistant tremor, and dyskinesias, benefit from advanced treatments such as therapy with levodopa-carbidopa enteral suspension or deep brain stimulation. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2020-02-01

    Hippocampal vascular reserve associated with cognitive performance and hippocampal volume

    ✓ Peer-reviewed Hippocampus size on brain scans Brain : a journal of neurology

    Key finding: Voxel-based morphometry showed higher anterior hippocampal grey matter volume in mixed, compared to single supply.

    Full summary, score breakdown and related studies → Original source

  12. 2020-02-01

    Evaluation of a Palliative Care Program for Nursing Homes in 7 Countries: The PACE Cluster-Randomized Clinical Trial

    ✓ Peer-reviewed End-of-life care JAMA internal medicine

    Key finding: Concerning deceased residents, we collected 551 of 610 questionnaires from staff at baseline and 984 of 1178 postintervention in 37 intervention and 36 control homes. +1 more finding

    Full summary, score breakdown and related studies → Original source

  13. 2020-02-01

    APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid

    ✓ Peer-reviewed Disease mechanisms Science translational medicine

    Key finding: We found that APOE4, but not APOE2 or APOE3, increased α-synuclein pathology, impaired behavioral performances, worsened neuronal and synaptic loss, and increased astrogliosis at 9 months of age.

    Full summary, score breakdown and related studies → Original source

  14. 2020-02-01

    65 Improving Medicines Safety for Care Homes Residents

    ✓ Peer-reviewed Health systems and care delivery Age and Ageing

    Key finding: Future direction of this work focuses on system wide improvements to promote multi-organisational interdisciplinary healthcare and social services professionals work in care homes. +1 more finding

    Full summary, score breakdown and related studies → Original source

  15. 2020-02-01

    Associations Between Vascular Risk Across Adulthood and Brain Pathology in Late Life: Evidence From a British Birth Cohort

    ✓ Peer-reviewed Long-term cohort studies JAMA neurology

    Key finding: Midlife vascular risk burden is associated with late-life dementia. +3 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2020-02-01

    APOE genotype regulates pathology and disease progression in synucleinopathy

    ✓ Peer-reviewed Caregiving Science translational medicine

    Key finding: Apolipoprotein E ( APOE ) ε4 genotype is associated with increased risk of dementia in Parkinson's disease (PD), but the mechanism is not clear, because patients often have a mixture of α-synuclein (αSyn), amyloid-β (Aβ), and tau pathologies. +4 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2020-02-01

    The effectiveness of nonpharmacological interventions for informal dementia caregivers: An updated systematic review and meta-analysis

    ✓ Peer-reviewed Caregiving Psychology and aging

    Key finding: Postintervention effects were significant for all outcomes when all interventions are pooled together. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2020-02-01

    Economics and mental health: the current scenario

    ✓ Peer-reviewed Prevention and risk World psychiatry : official journal of the World Psychiatric Association (WPA)

    Key finding: Here we consider how economic evaluation (including cost-effectiveness analysis, cost-utility analysis and related techniques) can contribute evidence to inform the development of mental health policy strategies, and to identify some consequences at the treatment or care level that are of relevance to service providers and funding bodies. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2020-02-01

    Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial

    ✓ Peer-reviewed Treatments JAMA neurology

    Key finding: Despite undetectable TPI-287 levels in CSF, CSF biomarkers demonstrated decreased chitinase-3-like protein-1 (YKL-40) levels in the 4RT treatment arm (mean [SD], -8.4 [26.0] ng/mL) compared with placebo (mean [SD], 10.4 [42.3] ng/mL; median difference, -14.6 [95% CI, -30.0 to 0.2] ng/mL; P = .048, Mann-Whitney test). +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2020-02-01

    Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial

    ✓ Peer-reviewed Treatments JAMA neurology

    Key finding: Of 544 eligible participants (241 women and 303 men), the mean (SD) age was 74.3 (8.2) years, and the mean (SD) sMMSE score was 26.4 (1.9).

    Full summary, score breakdown and related studies → Original source

  21. 2020-02-01

    Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease: The AMARANTH and DAYBREAK-ALZ Randomized Clinical Trials

    ✓ Peer-reviewed Treatments JAMA neurology

    Key finding: Among 2218 AMARANTH patients, the mean (SD) age was 71.3 (7.1) years, and 1177 of 2218 (53.1%) were women. +2 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2020-02-01

    Screening for Cognitive Impairment in Older Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

    ✓ Peer-reviewed Treatments JAMA

    Key finding: One randomized clinical trial (RCT) (n = 4005) examined the direct effect of screening for cognitive impairment on patient outcomes, including potential harms, finding no significant differences in health-related quality of life at 12 months (effect size, 0.009 [95% CI, -0.063 to 0.080]). +1 more finding

    Full summary, score breakdown and related studies → Original source

January 2020 3

  1. 2020-01-31

    “Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain”

    ✓ Peer-reviewed Down syndrome and Alzheimer's Molecular psychiatry

    Key finding: We report AD-like pathology in cerebral organoids grown in vitro from non-invasively sampled strands of hair from 71% of DS donors. +3 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2020-01-31

    Association between socioeconomic status and the development of mental and physical health conditions in adulthood: a multi-cohort study

    ✓ Peer-reviewed Prevention and risk The Lancet. Public health

    Key finding: During 1 110 831 person-years at risk, we recorded 245 573 hospitalisations in the Finnish cohorts; the corresponding numbers in the UK study were 60 946 hospitalisations in 186 572 person-years. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2020-01-30

    Dendritic Spines in Alzheimer's Disease: How the Actin Cytoskeleton Contributes to Synaptic Failure

    ✓ Peer-reviewed Disease mechanisms International journal of molecular sciences

    Key finding: These functional and structural modifications are considered the biological basis of learning and memory processes. +4 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →