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Reshaping the Amyloid Buildup Curve in Alzheimer Disease? Partial-Volume Effect Correction of Longitudinal Amyloid PET Data
Rullmann M, McLeod A, Grothe MJ, Sabri O, Barthel H, Alzheimer’s Disease Neuroimaging Initiative.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020-05-01
Topic: Amyloid, tau and blood-test diagnosis
Compared with non-PVE-corrected data, PVE-corrected data yielded significantly higher changes in regional and composite SUV ratio (SUVR) over time ( P = 0.0002 for composite SUVRs). Longitudinal SUVR changes in relation to Mini Mental State Examination decreases showed a significantly higher slope for the regression line in the PVE-corrected than in the non-PVE-corrected PET data ( F 1 = 7.1, P = 0.008). These PVEC results indicate that the β-amyloid buildup curve does not plateau at an early symptomatic disease stage. A further evaluation of the impact of PVEC on the in vivo characterization of time-dependent AD pathology, including the reliable assessment and comparison of other amyloid tracers, is warranted.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Rullmann, M., McLeod, A., Grothe, M. J., Sabri, O., Barthel, H., & Alzheimer’s Disease Neuroimaging Initiative. (2020). Reshaping the Amyloid Buildup Curve in Alzheimer Disease? Partial-Volume Effect Correction of Longitudinal Amyloid PET Data. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. https://doi.org/10.2967/jnumed.119.238477
Vancouver
Rullmann M, McLeod A, Grothe MJ, Sabri O, Barthel H, Alzheimer’s Disease Neuroimaging Initiative. Reshaping the Amyloid Buildup Curve in Alzheimer Disease? Partial-Volume Effect Correction of Longitudinal Amyloid PET Data. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2020. doi:10.2967/jnumed.119.238477. PMID: 32358089.
BibTeX
@article{rullmann2020-32358089,
author = {Rullmann, M. and McLeod, A. and Grothe, M. J. and Sabri, O. and Barthel, H. and {Alzheimer’s Disease Neuroimaging Initiative}},
title = {{Reshaping the Amyloid Buildup Curve in Alzheimer Disease? Partial-Volume Effect Correction of Longitudinal Amyloid PET Data}},
journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
year = {2020},
doi = {10.2967/jnumed.119.238477},
pmid = {32358089},
url = {https://doi.org/10.2967/jnumed.119.238477}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Compared with non-PVE-corrected data, PVE-corrected data yielded significantly higher changes in regional and composite SUV ratio (SUVR) over time ( P = 0.0002 for composite SUVRs).
- Longitudinal SUVR changes in relation to Mini Mental State Examination decreases showed a significantly higher slope for the regression line in the PVE-corrected than in the non-PVE-corrected PET data ( F 1 = 7.1, P = 0.008).
- These PVEC results indicate that the β-amyloid buildup curve does not plateau at an early symptomatic disease stage.
- A further evaluation of the impact of PVEC on the in vivo characterization of time-dependent AD pathology, including the reliable assessment and comparison of other amyloid tracers, is warranted.
Why it matters
Correcting for partial-volume effects changed longitudinal amyloid PET measurements and suggested the amyloid buildup curve does not plateau at an early symptomatic stage. This is a technical imaging analysis and does not test any treatment, cure or prevention.
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Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 46/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of nuclear medicine : official publication, Society of Nuclear Medicine) |
| Journal's citation record | 2 / 4 | Journal of Nuclear Medicine: journal h-index 230 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 12 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.5 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 2 / 6 | Cited 1.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Henryk Barthel: h-index 66 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Leipzig University: institution h-index 763 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32358089) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 46 / 100 | — |
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