Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 24,176–24,200 of 27,380 studies, newest first · page 968 of 1096.
March 2004 25
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2004-03-03
Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia
51/100 ✓ Peer-reviewed Risk factors Brain : a journal of neurology
Key finding: Salivary cortisol levels tended to be higher in the moderately demented subjects in the afternoon, but this effect was not specific to those with abnormal activity/rest patterns. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Development and preliminary validation of the pain assessment checklist for seniors with limited ability to communicate (PACSLAC)
36/100 ✓ Peer-reviewed Health systems and care delivery Pain management nursing : official journal of the American Society of Pain Management Nurses
Key finding: Analyses suggest that the PACSLAC discriminated among pain events (during which there was a clear and recognizable cause for the patients' pain), events during which patients were experiencing nonpainful distress, and situations during which patients were calm.
Full summary, score breakdown and related studies → Original source
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2004-03-01
Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics
40/100 ✓ Peer-reviewed Vascular contributions The Lancet. Neurology
Key finding: A bare-bones survey of the published research reveals no compelling evidence that amyloid deposition is neurotoxic in human beings or that it results in neurodegenerative changes involving synaptic, metabolic, or neuronal loss in human or transgenic-mouse brains. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-03-01
Glutathione metabolism and its implications for health
36/100 ✓ Peer-reviewed Risk factors The Journal of nutrition
Key finding: Animal and human studies demonstrate that adequate protein nutrition is crucial for the maintenance of GSH homeostasis. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Taurine prevents the neurotoxicity of beta-amyloid and glutamate receptor agonists: activation of GABA receptors and possible implications for Alzheimer's disease and other neurological disorders
36/100 ✓ Peer-reviewed Brain scans and imaging FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Key finding: The beta-amyloid peptide (Abeta) is centrally related to the pathogenesis of AD, and previous reports have demonstrated that the blockade of glutamate receptors prevents Abeta-induced neuronal death. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice
36/100 ✓ Peer-reviewed Biomarkers The Journal of neuroscience : the official journal of the Society for Neuroscience
Key finding: Previously, we found C-terminal-truncated fragments of apoE in AD brains and showed that such fragments can cause neurodegeneration and can induce NFT-like inclusions in cultured neuronal cells and in transgenic mice. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Magnetic resonance imaging of the brain in diabetes: the Cardiovascular Determinants of Dementia (CASCADE) Study
48/100 ✓ Peer-reviewed Vascular contributions Diabetes
Key finding: Diabetic patients are at increased risk for stroke, but little is known about the presence of other brain lesions. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
The neuropsychological profile of vascular cognitive impairment in stroke and TIA patients
52/100 ✓ Peer-reviewed Vascular contributions Neurology
Key finding: The cognitive deficits in VaD and VCI are characterized by disturbance of frontal functions, with less verbal memory impairment. +1 more finding
Full summary, score breakdown and related studies → Original source
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2004-03-01
Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis
43/100 ✓ Peer-reviewed Vascular contributions Journal of neurology, neurosurgery, and psychiatry
Key finding: Diffusion tensor measurements correlate better with cognition than conventional MRI measures. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Hippocampal volume, spectroscopy, cognition, and mood in patients receiving corticosteroid therapy
41/100 ✓ Peer-reviewed Hippocampus size on brain scans Biological psychiatry
Key finding: Patients receiving chronic corticosteroid therapy have smaller hippocampal volumes, lower N-acetyl aspartate ratios, and declarative memory deficits compared with controls. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Hippocampus and entorhinal cortex in mild cognitive impairment and early AD
47/100 ✓ Peer-reviewed Hippocampus size on brain scans Neurobiology of aging
Key finding: Volumes of the hippocampus and ERC were significantly reduced in the following order: control > MCI > AD. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Mitochondriopathies
36/100 ✓ Peer-reviewed Clinical safety European journal of neurology
Key finding: MCPs represent a diagnostic challenge because of their wide variation in presentation and course. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia
41/100 ✓ Peer-reviewed Inflammation and the immune system Neuropharmacology
Key finding: We examined the neuroprotective role of ibudilast in neuron and microglia co-cultures. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study
64/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology
Key finding: In cell culture experiments, flupirtine maleate (FLU), a triaminopyridine compound, was able to protect neuronal cells from apoptotic cell death induced by prion protein fragments and beta-amyloid peptides. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Effect of smoking on global cognitive function in nondemented elderly
64/100 ✓ Peer-reviewed Cognitive tests and assessment Neurology
Key finding: Contrary to early case-control studies that suggested smoking protects against Alzheimer disease (AD), recent prospective studies have shown that elderly who smoke may be at increased risk for dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Declining executive control in normal aging predicts change in functional status: the Freedom House Study
53/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of the American Geriatrics Society
Key finding: Three-year longitudinal cohort study. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Neurochemical diagnosis of Alzheimer's dementia by CSF Abeta42, Abeta42/Abeta40 ratio and total tau
52/100 ✓ Peer-reviewed Tau biomarkers Neurobiology of aging
Key finding: As compared to the other groups, the concentrations of Abeta42 and tTau were decreased (P<0.001) and increased (P<0.001) in AD, respectively, while Abeta40 did not differ significantly among the groups. +3 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Insulin and neurodegenerative disease: shared and specific mechanisms
51/100 ✓ Peer-reviewed Lewy body dementia The Lancet. Neurology
Key finding: We conclude by considering whether insulin dysregulation contributes to neurodegenerative disorders through disease-specific or general mechanisms.
Full summary, score breakdown and related studies → Original source
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2004-03-01
Risk factors for dementia in people with down syndrome: issues in assessment and diagnosis
38/100 ✓ Peer-reviewed Down syndrome and Alzheimer's American journal of mental retardation : AJMR
Key finding: It has been clearly established that there is an increased incidence of early onset dementia of the Alzheimer type (DAT) in people who have Down syndrome. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms?
41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Clinica chimica acta; international journal of clinical chemistry
Key finding: Our data supported the presumption of increased oxidative stress in DS. +4 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Predictors of cognitive decline and mortality of aged people over a 10-year period
55/100 ✓ Peer-reviewed Risk factors The journals of gerontology. Series A, Biological sciences and medical sciences
Key finding: Long follow-up of a general aged population explains several inconsistencies of earlier reports. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Huntington's disease: present treatments and future therapeutic modalities
35/100 ✓ Peer-reviewed Digital health tools International clinical psychopharmacology
Key finding: We conclude that there is definitely poor evidence in management of HD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Cognition and anatomy in three variants of primary progressive aphasia
62/100 ✓ Peer-reviewed Digital health tools Annals of neurology
Key finding: Voxel-based morphometry (VBM) on MRIs showed that, when all 31 PPA patients were analyzed together, the left perisylvian region and the anterior temporal lobes were atrophied. +2 more findings
Full summary, score breakdown and related studies → Original source
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2004-03-01
Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function
57/100 ✓ Peer-reviewed How common it is Archives of neurology
Key finding: Longitudinal clinicopathologic cohort study.
Full summary, score breakdown and related studies → Original source
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2004-03-01
Predictors of nursing facility admission: a 12-year epidemiological study in the United States
62/100 ✓ Peer-reviewed Disparities Journal of the American Geriatrics Society
Key finding: Dementia emerged as the most potent risk factor for institutionalization in this 12-year community-based epidemiological study. +2 more findings
Full summary, score breakdown and related studies → Original source
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