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Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease
Wang H, Yang J, Schneider JA, De Jager PL, Bennett DA, Zhang HY.. Neurobiology of aging, 2020-04-29
Topic: Amyloid, tau and blood-test diagnosis
Genome-wide association studies have identified many loci associated with Alzheimer's dementia. However, these variants only explain part of the heritability of Alzheimer's disease (AD). As genetic epistasis can be a major contributor to the "missing heritability" of AD, we conducted genome-wide epistasis screening for AD pathologies in 2 independent cohorts.
Key findings
- However, these variants only explain part of the heritability of Alzheimer's disease (AD).
- As genetic epistasis can be a major contributor to the "missing heritability" of AD, we conducted genome-wide epistasis screening for AD pathologies in 2 independent cohorts.
- First, we performed a genome-wide epistasis study of AD-related brain pathologies (N max = 1318) in ROS/MAP.
- Candidate interactions were validated using cerebrospinal fluid biomarkers of AD in ADNI (N max = 1128).
Why it matters
This study searched for gene-gene interactions related to Alzheimer's disease pathologies in two independent cohorts. It is genetic and observational, so it does not provide a treatment or cure.
Study details
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | 3 / 4 | Neurobiology of Aging: journal h-index 263 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 106 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 13.2 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 7.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 3 / 4 | Cited 51 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Hongyu Zhang: h-index 58 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Broad Institute: institution h-index 2,541 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32450446) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.neurobiolaging.2020.04.025
- PubMed: 32450446
- Original source →
- Free full text: Neurobiology of Aging →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Wang, H., Yang, J., Schneider, J. A., De Jager, P. L., Bennett, D. A., & Zhang, H. Y. (2020). Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2020.04.025
Vancouver
Wang H, Yang J, Schneider JA, De Jager PL, Bennett DA, Zhang HY. Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease. Neurobiology of aging. 2020. doi:10.1016/j.neurobiolaging.2020.04.025. PMID: 32450446.
BibTeX
@article{wang2020-32450446,
author = {Wang, H. and Yang, J. and Schneider, J. A. and De Jager, P. L. and Bennett, D. A. and Zhang, H. Y.},
title = {{Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease}},
journal = {Neurobiology of aging},
year = {2020},
doi = {10.1016/j.neurobiolaging.2020.04.025},
pmid = {32450446},
url = {https://doi.org/10.1016/j.neurobiolaging.2020.04.025}
}
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