Newest studies

Assessment of changes in place of death of older adults who died from dementia in the United States, 2000–2014: a time-series cross-sectional analysis

42/100 ✓ Peer-reviewed Health systems and care delivery BMC Public Health

Key finding: Dementia decedents were more likely to die at home and other places and less likely to die at institutional settings over the study period. +4 more findings

• Care Services
• End-of-Life Care

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Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities

71/100 ✓ Peer-reviewed Long-term cohort studies Stroke

Key finding: Periventricular white matter hyperintensities (WMH; PVWMH) and deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in cause. +3 more findings

• Genetics
• Brain Scans

Full summary, score breakdown and related studies → Original source

ATN classification and clinical progression in subjective cognitive decline: The SCIENCe project

64/100 ✓ Peer-reviewed Biomarkers Neurology

Key finding: Among individuals presenting with SCD at a memory clinic, those with a biomarker profile A-T+N+, A+T-N-, A+T+N-, and A+T+N+ were at increased risk of dementia, and showed steeper cognitive decline compared to A-T-N- individuals. +3 more findings

• Biomarkers
• Early Stage

Full summary, score breakdown and related studies → Original source

TDP-1/TDP-43 potentiates human α-Synuclein (HASN) neurodegeneration in Caenorhabditis elegans

39/100 ✓ Peer-reviewed Brain tissue and pathology Biochimica et biophysica acta. Molecular basis of disease

Key finding: RNA-seq studies suggested that tdp-1 supports expression of lysosomal genes and decreases expression of genes involved in heat shock. +3 more findings

• Brain Biology
• Other Dementias

Full summary, score breakdown and related studies → Original source

Frailty and Mortality in Hospitalized Older Adults With COVID-19: Retrospective Observational Study

48/100 ✓ Peer-reviewed Clinical safety Journal of the American Medical Directors Association

Key finding: Although their prognosis is worse, even the oldest and most severely frail patients may benefit from hospitalization for COVID-19, if sufficient resources are available. +4 more findings

• Care Services

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Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration

46/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in cellular neuroscience

Key finding: The terminal sugar residue of all glycoproteins and glycolipids on the surface of mammalian cells is normally sialic acid, and addition of this negatively charged residue is known as "sialylation," whereas removal by sialidases is known as "desialylation." +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

Generalizable, Reproducible, and Neuroscientifically Interpretable Imaging Biomarkers for Alzheimer's Disease

55/100 ✓ Peer-reviewed Digital health tools Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Key finding: Significant associations between the classification output and clinical characteristics of AD and mild cognitive impairment (MCI, a middle stage of dementia) groups provide solid neurobiological support for the 3DAN model.

• Brain Scans
• Digital Tools
• Biomarkers

Full summary, score breakdown and related studies → Original source

Effects of Physical Activity on Brain Energy Biomarkers in Alzheimer's Diseases

39/100 ✓ Peer-reviewed Prevention trials Diseases (Basel, Switzerland)

Key finding: In this review, examine the risk factors associated with AD and the effects physical activity may play in the prevention of the degenerative process of this disease, loss of memory and cognitive performance in the elderly. +1 more finding

• Prevention
• Lifestyle

Full summary, score breakdown and related studies → Original source

Autonomic flexibility reflects learning and associated neuroplasticity in old age

67/100 ✓ Peer-reviewed Prevention trials Human brain mapping

Key finding: Furthermore, the revealed ANS shapelet significantly predicted training-induced neuroplasticity in the dorsal anterior cingulate cortex and select frontal regions during task fMRI. +1 more finding

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Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

49/100 ✓ Peer-reviewed TREM2 and immune genetics Nature neuroscience

Key finding: Although studies in mouse models have implicated specific Trem2-dependent microglial functions in AD, the underlying molecular mechanisms and translatability to human disease remain poorly defined. +3 more findings

• Genetics
• Brain Biology

Full summary, score breakdown and related studies → Original source

FastSurfer - A fast and accurate deep learning based neuroimaging pipeline

67/100 ✓ Peer-reviewed How common it is NeuroImage

Key finding: To this end, we introduce an advanced deep learning architecture capable of whole-brain segmentation into 95 classes. +4 more findings

• Brain Scans
• Digital Tools

Full summary, score breakdown and related studies → Original source

Differential levels of Neurofilament Light protein in cerebrospinal fluid in patients with a wide range of neurodegenerative disorders

59/100 ✓ Peer-reviewed Biomarkers Scientific reports

Key finding: Furthermore, we found an association of CSF NfL levels with cognitive impairment in patients within the AD and FTD spectrum and with AD pathology in DLB and DS patients. +1 more finding

• Biomarkers
• Other Dementias

Full summary, score breakdown and related studies → Original source

A Mobile Application for Smart Computer-Aided Self-Administered Testing of Cognition, Speech, and Motor Impairment

45/100 ✓ Peer-reviewed Cognitive tests and assessment Sensors

Key finding: The best results were achieved using a fusion of 13 classifiers for combined finger tapping and SAGE features (96.12% accuracy), and using bidirectional long short-term memory (BiLSTM) (94.29% accuracy) for speech analysis features.

• Diagnosis
• Digital Tools

Full summary, score breakdown and related studies → Original source

Patient and caregiver outcomes at the integrated memory care clinic

55/100 ✓ Peer-reviewed Health systems and care delivery Geriatric nursing (New York, N.Y.)

Key finding: Statistically significant improvements in 5 sub-scales of the Neuropsychiatric Inventory were observed: caregivers' distress regarding their PLWDs' delusions and anxiety, and PLWDs' severity of delusions, depression, and total symptom severity.

• Caregiving

Full summary, score breakdown and related studies → Original source

Optical coherence tomography reveals light-dependent retinal responses in Alzheimer's disease

39/100 ✓ Peer-reviewed Brain scans and imaging NeuroImage

Key finding: In eight healthy young adults, light-dependent increases in reflectivity were easily demonstrated at photoreceptor inner and outer segments, changing by ~7% in bright light and ~3% in dim light.

Full summary, score breakdown and related studies → Original source

Small RNA fingerprinting of Alzheimer's disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles

41/100 ✓ Peer-reviewed Biomarkers Journal of extracellular vesicles

Key finding: These results provide a blueprint into the biological pathways potentially effected during disease that may be assisted by brain-derived EV RNA horizontal transfer. +1 more finding

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Opioid system influences gut-brain axis: Dysbiosis and related alterations

39/100 ✓ Peer-reviewed Disease mechanisms Pharmacological research

Key finding: Opioid drugs are widely used to treat chronic pain, but their misuse can lead to tolerance, dependence, and addiction and have created a significant public health problem. +1 more finding

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MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy

38/100 ✓ Peer-reviewed Disease mechanisms The Journal of pharmacology and experimental therapeutics

Key finding: In the rTg4510 mouse model of human tauopathy, MK-8719 significantly increases brain O -GlcNAc levels and reduces pathologic tau. +3 more findings

• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

Optical Coherence Tomography Angiography in Neurodegenerative Disorders

39/100 ✓ Peer-reviewed Brain scans and imaging Journal of clinical medicine

Key finding: Retinal microcirculation shares similar features with cerebral small blood vessels. +4 more findings

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Mediterranean diet adherence is associated with better cognitive status and less depressive symptoms in a Greek elderly population

43/100 ✓ Peer-reviewed Prevention trials Aging clinical and experimental research

Key finding: Higher MD adherence is strongly associated with better cognitive status and less depressive symptomatology. +4 more findings

• Lifestyle

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The Role of Nutrition in Individualized Alzheimer's Risk Reduction

39/100 ✓ Peer-reviewed Prevention and risk Current nutrition reports

Key finding: RECENT FINDINGS: Specific dietary patterns and varied nutrient combinations can have a protective effect on brain health, promote cognitive function, and mediate the comorbidity of chronic conditions associated with increased AD risk.

• Prevention
• Lifestyle
• Risk Factors

Full summary, score breakdown and related studies → Original source

The role of GLP-1/GIP receptor agonists in Alzheimer's disease

39/100 ✓ Peer-reviewed Drug development Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Key finding: Different concentrations of OA were able to induce apoptosis of SH-SY5Y cells in a dose-dependent manner. +4 more findings

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Clinical and public health implications of periodontal and systemic diseases: An overview

41/100 ✓ Peer-reviewed Costs and economics Periodontology 2000

Key finding: It is the sixth most common human disease and is estimated to affect 11.2% of the global adult population, hence representing a significant healthcare, social, and economic burden. +1 more finding

• Risk Factors

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Rapid improvement in Alzheimer's disease symptoms following fecal microbiota transplantation: a case report

47/100 ✓ Peer-reviewed Disease mechanisms The Journal of international medical research

Key finding: Given the health and economic impacts of AD, treatments that target the underlying etiology of AD or modify the course of the disease are of significant interest. +1 more finding

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Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease

50/100 ✓ Peer-reviewed Genetics Molecular systems biology

Key finding: From three independent studies (197 individuals), we characterize differences in proteins by AD status (> 1,000 proteins, CV < 20%). +4 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source