Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 11,626–11,650 of 27,380 studies, newest first · page 466 of 1096.
May 2020 25
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2020-05-16
Albuminuria and Estimated GFR as Risk Factors for Dementia in Midlife and Older Age: Findings From the ARIC Study
57/100 ✓ Peer-reviewed Long-term cohort studies American journal of kidney diseases : the official journal of the National Kidney Foundation
Key finding: & objective Evidence is limited on how estimated glomerular filtration rate (eGFR) and urinary albumin-creatinine ratio (UACR) relate to dementia at different ages. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-16
IoT Wearable Sensors and Devices in Elderly Care: A Literature Review
49/100 ✓ Peer-reviewed Digital health tools Sensors (Basel, Switzerland)
Key finding: In turn, there is a need for constant monitoring and assistance, intervention, and support, causing a considerable financial and human burden on individuals and their caregivers. +4 more findings
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2020-05-15
Cerebral amyloid angiopathy with focal presentation-about 3 cases
45/100 ✓ Peer-reviewed Vascular contributions Neuroradiology
Key finding: Cerebral amyloid angiopathy (CAA) is a common cerebrovascular disease involved in ischemic and hemorrhagic strokes, and its progression is correlated to cognitive decline. +4 more findings
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2020-05-15
Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer's Disease
39/100 ✓ Peer-reviewed Genetics Oxidative medicine and cellular longevity
Key finding: Research data suggest that APOE4 leads to the pathogenesis of AD through various processes such as accelerated beta-amyloid aggregations that raised neurofibrillary tangle formation, cerebrovascular diseases, aggravated neuroinflammation, and synaptic loss.
Full summary, score breakdown and related studies → Original source
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2020-05-15
Commentary: Composite cognitive and functional measures for early stage Alzheimer's disease trials
43/100 ✓ Peer-reviewed Cognitive tests and assessment Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: I suggest that the results of exploratory studies be used to help identify target domains for confirmatory studies.
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2020-05-15
Advance care planning: the future
40/100 ✓ Peer-reviewed End-of-life care BMJ supportive & palliative care
Key finding: ACP practices are evolving.
Full summary, score breakdown and related studies → Original source
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2020-05-14
Mechanisms of neurodegeneration - Insights from familial Alzheimer's disease
39/100 ✓ Peer-reviewed Risk genes beyond APOE Seminars in cell & developmental biology
Key finding: Genetics has provided invaluable clues to the genesis of the disease by revealing deterministic genes - Presenilins (PSENs) and the Amyloid Precursor Protein (APP) - that, when affected, lead in an autosomal dominant manner to early-onset, familial AD (FAD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-14
SCAI expert consensus statement on out of hospital cardiac arrest
68/100 ✓ Peer-reviewed Risk factors Catheterization and Cardiovascular Interventions
Key finding: Out of hospital cardiac arrest (OHCA) remains a significant public health problem with high mortality and morbidity. +4 more findings
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2020-05-14
Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer's Disease
45/100 ✓ Peer-reviewed Prevention and risk Trends in molecular medicine
Key finding: No effective drug is available to treat AD and about one-third of depressive patients show treatment resistance. +4 more findings
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2020-05-13
Understanding the Pathophysiology of Cerebral Amyloid Angiopathy
39/100 ✓ Peer-reviewed Vascular contributions International journal of molecular sciences
Key finding: Cerebral amyloid angiopathy (CAA), one of the main types of cerebral small vessel disease, is a major cause of spontaneous intracerebral haemorrhage and an important contributor to cognitive decline in elderly patients. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-13
MAPT haplotype-stratified GWAS reveals differential association for AD risk variants
55/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: We identified 11 loci-5 in H2-non-carriers and 6 in H2-carriers-although none of the MAPT haplotype-specific associations achieved genome-wide significance. +4 more findings
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2020-05-13
Early Detection of Alzheimer's Disease Using Magnetic Resonance Imaging: A Novel Approach Combining Convolutional Neural Networks and Ensemble Learning
41/100 ✓ Peer-reviewed Digital health tools Frontiers in neuroscience
Key finding: The result revealed an accuracy rate of 0.84 ± 0.05, 0.79 ± 0.04, and 0.62 ± 0.06, respectively, for classifying AD vs. +1 more finding
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2020-05-13
Neuron tau-targeting biomimetic nanoparticles for curcumin delivery to delay progression of Alzheimer's disease
15/100 ⚠ Retracted — do not rely on it Drug development Journal of nanobiotechnology
Key finding: Intravenous neuronal tau-targeted T807-modified novel biomimetic nanosystems are a promising clinical candidate for the treatment of AD. +2 more findings
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2020-05-13
TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling
43/100 ✓ Peer-reviewed TREM2 and immune genetics PLoS pathogens
Key finding: TREM2 is mainly expressed on dendritic cells and macrophages, the target cells of porcine reproductive and respiratory syndrome virus (PRRSV). +3 more findings
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2020-05-13
C9orf72 suppresses systemic and neural inflammation induced by gut bacteria
56/100 ✓ Peer-reviewed Caregiving Nature
Key finding: Here we report that an environment with reduced abundance of immune-stimulating bacteria 10,11 protects C9orf72-mutant mice from premature mortality and significantly ameliorates their underlying systemic inflammation and autoimmunity. +1 more finding
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2020-05-12
Telehealth Home Support During COVID-19 Confinement for Community-Dwelling Older Adults With Mild Cognitive Impairment or Mild Dementia: Survey Study
52/100 ✓ Peer-reviewed Risk factors Journal of Medical Internet Research
Key finding: Of the respondents, 60/93 (65%) were women. +4 more findings
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2020-05-12
Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula
43/100 ✓ Peer-reviewed TREM2 and immune genetics Brain, behavior, and immunity
Key finding: The ketogenic diet (KD) has been reported to exhibit preventative effects on depressive-like behaviors in rodents. +3 more findings
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2020-05-12
Effects of physical exercise on cognitive function of older adults with mild cognitive impairment: A systematic review and meta-analysis
64/100 ✓ Peer-reviewed Prevention and risk Archives of gerontology and geriatrics
Key finding: PE improves global cognitive function (SMD = 0.348 [95 % CI 0.166 to 0.529]; p = 0.0001), executive function (SMD = 0.213 [95 % CI 0.026 to 0.400]; p = 0.026) and delayed recall (SMD = 0.180 [95 % CI 0.002 to 0.358]; p = 0.047). +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-12
The implications of different approaches to define AT(N) in Alzheimer disease
67/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: Our findings show that different AT(N) variants are not interchangeable, and that optimal variants differ by clinical stage. +3 more findings
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2020-05-11
Prevalence and geographical variation of dementia in New Zealand from 2012 to 2015: Brief report utilising routinely collected data within the Integrated Data Infrastructure
47/100 ✓ Peer-reviewed Risk factors Australasian Journal on Ageing
Key finding: Approximately 2% of those aged ≥60 years had dementia, lower than published estimates. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-11
Longitudinal trajectories of Alzheimer's ATN biomarkers in elderly persons without dementia
59/100 ✓ Peer-reviewed Long-term cohort studies Alzheimer's research & therapy
Key finding: Models of Alzheimer's disease (AD) pathophysiology posit that amyloidosis [A] precedes and accelerates tau pathology [T] that leads to neurodegeneration [N]. +3 more findings
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2020-05-09
Medical Ethics Issues in Dementia and End of Life
39/100 ✓ Peer-reviewed End-of-life care Current psychiatry reports
Key finding: I review ethical and legal challenges for end of life (EOL) care in dementia. +4 more findings
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2020-05-09
Obesity and Age-Related Changes in the Brain of the Zucker Lepr fa/fa Rats
39/100 ✓ Peer-reviewed Risk factors Nutrients
Key finding: The purpose of this work is to investigate brain microanatomy alterations in obese Zucker rats (OZRs), as a model of MetS, compared to their counterparts lean Zucker rats (LZRs). 12-, 16-, and 20-weeks-old male OZRs and LZRs were studied. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-08
Short-term associations between ambient air pollution and acute atrial fibrillation episodes
54/100 ✓ Peer-reviewed Risk factors Environment international
Key finding: Among 218 participants with 469 AF episodes we observed higher odds of AF following higher 24-hour mean levels of PM10 and O3, reaching statistical significance for PM10 levels averaged over the previous 12-24-hours [OR 1.10 (95%CI 1.01-1.19) per IQR of PM10 (7.8 µg/m3)]. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-05-08
Clinical significance of fluid biomarkers in Alzheimer's Disease
39/100 ✓ Peer-reviewed Biomarkers Pharmacological reports : PR
Key finding: Upper panel: Aβ peptides are released from transmembrane Amyloid Precursor Protein (APP) under physiological conditions (blue arrow). +4 more findings
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