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Cerebral Microhemorrhage at MRI in Mild Cognitive Impairment and Early Alzheimer Disease: Association with Tau and Amyloid β at PET Imaging
Rauchmann BS, Ghaseminejad F, Mekala S, Perneczky R, Alzheimer’s Disease Neuroimaging Initiative.. Radiology, 2020-05-05
Topic: Amyloid, tau and blood-test diagnosis
Background Growing evidence indicates an association between cerebral microhemorrhages (MHs) and amyloid β accumulation in Alzheimer disease (AD), but to the knowledge of the authors the association with tau burden is unknown. Purpose To investigate the association between cerebral MH load and tau pathologic structure measured in healthy older individuals and individuals along the AD spectrum, stratified by using the A (amyloid β)/T (tau)/N (neurodegeneration) biomarker classification system. Materials and methods In this prospective cohort study, participants from the AD Neuroimaging Initiative were included (healthy control participants, participants with mild cognitive impairment, and participants with AD dementia; data from October 2005 to January 2019).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Rauchmann, B. S., Ghaseminejad, F., Mekala, S., Perneczky, R., & Alzheimer’s Disease Neuroimaging Initiative. (2020). Cerebral Microhemorrhage at MRI in Mild Cognitive Impairment and Early Alzheimer Disease: Association with Tau and Amyloid β at PET Imaging. Radiology. https://doi.org/10.1148/radiol.2020191904
Vancouver
Rauchmann BS, Ghaseminejad F, Mekala S, Perneczky R, Alzheimer’s Disease Neuroimaging Initiative. Cerebral Microhemorrhage at MRI in Mild Cognitive Impairment and Early Alzheimer Disease: Association with Tau and Amyloid β at PET Imaging. Radiology. 2020. doi:10.1148/radiol.2020191904. PMID: 32368960.
BibTeX
@article{rauchmann2020-32368960,
author = {Rauchmann, B. S. and Ghaseminejad, F. and Mekala, S. and Perneczky, R. and {Alzheimer’s Disease Neuroimaging Initiative}},
title = {{Cerebral Microhemorrhage at MRI in Mild Cognitive Impairment and Early Alzheimer Disease: Association with Tau and Amyloid β at PET Imaging}},
journal = {Radiology},
year = {2020},
doi = {10.1148/radiol.2020191904},
pmid = {32368960},
url = {https://doi.org/10.1148/radiol.2020191904}
}
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Key findings
- Purpose To investigate the association between cerebral MH load and tau pathologic structure measured in healthy older individuals and individuals along the AD spectrum, stratified by using the A (amyloid β)/T (tau)/N (neurodegeneration) biomarker classification system.
- Materials and methods In this prospective cohort study, participants from the AD Neuroimaging Initiative were included (healthy control participants, participants with mild cognitive impairment, and participants with AD dementia; data from October 2005 to January 2019).
- T2*-weighted gradient-echo MRI was performed to quantify MH, fluorine 18 ( 18 F) flortaucipir (AV-1451) PET was performed to quantify tau, and 18 F-florbetaben/ 18 F- florbetapir (AV45) PET was performed to quantify amyloid β to study associations of MH with regional and global tau and amyloid β load.
- Associations with cerebrospinal fluid (CSF) biomarkers (amyloid β1-42, total tau, phosphorylated tau 181) were also assessed.
Why it matters
This study looked at whether small bleeds in the brain, seen on MRI, are related to tau and amyloid buildup seen on PET scans in people across the Alzheimer's spectrum. It is an observational study and does not test any treatment or prevention.
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Study details
- Study designcohort study
- Evidence strengthModerate
How this study scored 48/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 46 of the 96 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Radiology) |
| Journal's citation record | 3 / 4 | Radiology: journal h-index 431 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 15 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.9 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 2 / 6 | Cited 1.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 1 / 4 | Cited 6 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 2 / 3 | Imperial College London: institution h-index 1,744 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32368960) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 46 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 46 of the 96 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
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