Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 11,901–11,925 of 27,380 studies, newest first · page 477 of 1096.
February 2020 25
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2020-02-12
Insights into Systemic Disease through Retinal Imaging-Based Oculomics
50/100 ✓ Peer-reviewed Digital health tools Translational vision science & technology
Key finding: Population-based analyses have demonstrated the predictive value of retinal microvascular indices, as measured through fundus photography, in screening for heart attack and stroke.
Full summary, score breakdown and related studies → Original source
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2020-02-12
Potential Benefits of Physical Activity in MCI and Dementia
49/100 ✓ Peer-reviewed Prevention and risk Behavioural neurology
Key finding: Physical activity improves overall health and reduces the risk of many negative health outcomes and may be effective in improving cognition, independent functioning, and psychological health in older adults.
Full summary, score breakdown and related studies → Original source
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2020-02-11
Cellular Senescence in Neurodegenerative Diseases
41/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Frontiers in cellular neuroscience
Key finding: Another important feature associated with senescence is altered proteostasis.
Full summary, score breakdown and related studies → Original source
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2020-02-11
Alzheimer's disease: targeting the glutamatergic system
41/100 ✓ Peer-reviewed Treatments Biogerontology
Key finding: Much work has focussed on the post-synaptic response with little insight into how glutamate is regulated more broadly in the brain and the influence of anaplerotic pathways that finely tune these mechanisms. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-02-11
Biological subtypes of Alzheimer disease: A systematic review and meta-analysis
74/100 ✓ Peer-reviewed Genetics Neurology
Key finding: We identified 2 core dimensions of heterogeneity: typicality and severity. +1 more finding
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2020-02-10
Is Sleep Disruption a Cause or Consequence of Alzheimer's Disease? Reviewing Its Possible Role as a Biomarker
39/100 ✓ Peer-reviewed Tau biomarkers International journal of molecular sciences
Key finding: Nowadays, we know that sleep is crucial to consolidate memory and to remove the excess of beta-amyloid and hyperphosphorilated tau accumulated in AD patients' brains. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-02-10
Identification of early pericyte loss and vascular amyloidosis in Alzheimer's disease retina
48/100 ✓ Peer-reviewed Brain scans and imaging Acta neuropathologica
Key finding: Here, by modifying a method of enzymatically clearing non-vascular retinal tissue and fluorescent immunolabeling of the isolated blood vessel network, we identified substantial pericyte loss together with significant Aβ deposition in retinal microvasculature and pericytes in AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-02-08
An evaluation of hydromethylthionine as a treatment option for Alzheimer's disease
46/100 ✓ Peer-reviewed Drug development Expert opinion on pharmacotherapy
Key finding: Alzheimer's disease (AD) is a major cause of morbidity worldwide and its prevalence is expected to rise.
Full summary, score breakdown and related studies → Original source
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2020-02-07
Small Vessel Disease-Related Dementia: An Invalid Neurovascular Coupling?
39/100 ✓ Peer-reviewed Vascular contributions International journal of molecular sciences
Key finding: The apparent consequence (or a first event, too) is the macroscopic alteration of the neurovascular coupling. +4 more findings
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2020-02-07
Natural and synthetic drugs used for the treatment of the dementia
39/100 ✓ Peer-reviewed Treatments Biochemical and biophysical research communications
Key finding: This review is devoted to comparative pharmacological analysis of synthetic drugs such as memantine and its isomers, as well as tacrine, velnacrine, rivastigmine, and donepezil, with natural alkaloids, terpenoids, and triterpenoid peroxides, which are used to treat dementia, Alzheimer's and Parkinson's diseases, myasthenia gravis and other neurodegenerative diseases. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-02-07
Validation of a novel and accurate ApoE4 assay for automated chemistry analyzers
39/100 ✓ Peer-reviewed Genetics Scientific reports
Key finding: Furthermore, we demonstrated that the e4Risk test can be adapted to any clinical chemistry analyzer, including the high throughput analyzers present in most hospitals and clinical laboratories.
Full summary, score breakdown and related studies → Original source
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2020-02-07
Impact of HMGB1, RAGE, and TLR4 in Alzheimer's Disease (AD): From Risk Factors to Therapeutic Targeting
48/100 ✓ Peer-reviewed Inflammation and the immune system Cells
Key finding: AD presents a serious global health concern with no cure to date, reflecting the complexity of its pathogenesis. +3 more findings
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2020-02-07
Associations of cigarette smoking with gray and white matter in the UK Biobank
51/100 ✓ Peer-reviewed Long-term cohort studies Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Key finding: In the current study, we assessed the relationship of cigarette smoking with gray matter (GM) and white matter (WM) in the UK Biobank, controlling for numerous confounding demographic and health variables. +3 more findings
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2020-02-06
Interaction between APOE genotype and diabetes in cognitive decline
43/100 ✓ Peer-reviewed Genetics Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: A significant interaction between diabetes and APOE genotype exists, where diabetes affected cognitive decline in APOE3 carriers and APOE2 carriers, but not APOE4 carriers. +2 more findings
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2020-02-06
Neuroanatomical spread of amyloid β and tau in Alzheimer's disease: implications for primary prevention
65/100 ✓ Peer-reviewed Mild cognitive impairment Brain communications
Key finding: Regions with early signs of elevated amyloid β uptake were used to form an early, focal composite and compared to a commonly used global composite, in a separate validation sample. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-02-06
Down syndrome
56/100 ✓ Peer-reviewed How common it is Nature reviews. Disease primers
Key finding: Trisomy 21, the presence of a supernumerary chromosome 21, results in a collection of clinical features commonly known as Down syndrome (DS).
Full summary, score breakdown and related studies → Original source
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2020-02-06
Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease
49/100 ✓ Peer-reviewed Genetics Neurobiology of disease
Key finding: Moreover, AD brain is under a high degree of oxidative stress, including that associated with amyloid β-peptide (Aβ) oligomers. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-02-05
Management of mild cognitive impairment (MCI): The need for national and international guidelines
41/100 ✓ Peer-reviewed Prevention trials The World Journal of Biological Psychiatry
Key finding: Consensus diagnostic criteria for MCI are available, making early recognition and accurate classification of MCI subtypes possible. +4 more findings
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2020-02-05
Therapy for Insomnia and Circadian Rhythm Disorder in Alzheimer Disease
39/100 ✓ Peer-reviewed Risk factors Current treatment options in neurology
Key finding: RECENT FINDINGS: Some studies investigated the efficacy and safety of hypnotic agents as ramelteon and mirtazapine to treat sleep disorders in AD but no significant therapeutic effects have been observed. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-02-05
A Deep Siamese Convolution Neural Network for Multi-Class Classification of Alzheimer Disease
49/100 ✓ Peer-reviewed Brain scans and imaging Brain sciences
Key finding: Alzheimer's disease (AD) may cause damage to the memory cells permanently, which results in the form of dementia.
Full summary, score breakdown and related studies → Original source
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2020-02-05
Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy
61/100 ✓ Peer-reviewed Getting a diagnosis Nature
Key finding: Synucleinopathies are neurodegenerative diseases that are associated with the misfolding and aggregation of α-synuclein, including Parkinson's disease, dementia with Lewy bodies and multiple system atrophy 1 . +3 more findings
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2020-02-04
Hypertension, Antihypertensive Use and the Delayed-Onset of Huntington's Disease
68/100 ✓ Peer-reviewed Risk factors Movement disorders : official journal of the Movement Disorder Society
Key finding: Huntington's disease patients had a lower prevalence of hypertension compared with age-matched gene-negative controls. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-02-04
New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota
38/100 ✓ Peer-reviewed Disease mechanisms Progress in neuro-psychopharmacology & biological psychiatry
Key finding: As a result, the expression of NLRP3 was increased in the intestinal tract of mice, and the expression levels of inflammatory factors in peripheral blood were also increased. +2 more findings
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2020-02-04
Reduced repressive epigenetic marks, increased DNA damage and Alzheimer's disease hallmarks in the brain of humans and mice exposed to particulate urban air pollution
40/100 ✓ Peer-reviewed Risk factors Environmental research
Key finding: Exposure to air pollutants is associated with an increased risk of developing Alzheimer's disease (AD). +3 more findings
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2020-02-04
Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease
41/100 ✓ Peer-reviewed Drug development Acta neuropathologica communications
Key finding: E2814 and its murine precursor, 7G6, as revealed by epitope mapping, are antibodies bi-epitopic for 4R and mono-epitopic for 3R tau isoforms because they bind to sequence motif HVPGG. +2 more findings
Full summary, score breakdown and related studies → Original source
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