Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 11,026–11,050 of 27,380 studies, newest first · page 442 of 1096.
October 2020 25
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2020-10-30
Age- and Sex-Specific Prevalence and Modifiable Risk Factors of Mild Cognitive Impairment Among Older Adults in China: A Population-Based Observational Study
50/100 ✓ Peer-reviewed Risk factors Frontiers in Aging Neuroscience
Key finding: The mean (SD) age of the 4,631 participants was 67.6 (4.89) years, and 2579 (55.7%) were women. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-10-30
Alzheimer's Disease Detection Through Whole-Brain 3D-CNN MRI
51/100 ✓ Peer-reviewed Digital health tools Frontiers in bioengineering and biotechnology
Key finding: Contributions of our study include devising a deep learning system that is entirely automatic and comparatively fast, presenting competitive results without using any patient's domain-specific knowledge about the disease.
Full summary, score breakdown and related studies → Original source
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2020-10-30
Effect of 1 Year of Qigong Exercise on Cognitive Function Among Older Chinese Adults at Risk of Cognitive Decline: A Cluster Randomized Controlled Trial
49/100 ✓ Peer-reviewed Treatments Frontiers in psychology
Key finding: Twenty-five of 33 (75.8%) participants in the qigong group and 26 of 33 (78.8%) participants in the control group completed the 1-year exercise programs. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-10-29
Alogliptin Attenuates Lipopolysaccharide-Induced Neuroinflammation in Mice Through Modulation of TLR4/MYD88/NF-κB and miRNA-155/SOCS-1 Signaling Pathways
41/100 ✓ Peer-reviewed Drug development The International Journal of Neuropsychopharmacology
Key finding: Alogliptin treatment alleviated LPS-induced cognitive impairment as assessed by Morris water maze and novel object recognition tests. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-10-29
Importance of loneliness in behavioral and psychological symptoms of dementia
50/100 ✓ Peer-reviewed Risk factors International journal of geriatric psychiatry
Key finding: The revised UCLA loneliness scale score was not significantly associated with age, years of education, mini-mental state examination (MMSE) score, gender, living status, visual impairment, hearing impairment, and marital status. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-10-29
The risk factors for postoperative delirium in adult patients after hip fracture surgery: a systematic review and meta-analysis
78/100 ✓ Peer-reviewed Clinical safety International journal of geriatric psychiatry
Key finding: Patients possessed above risk factors might be high-risk patients. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-10-29
Racial disparities in medication use: imperatives for managed care pharmacy
36/100 ✓ Peer-reviewed Health systems and care delivery Journal of Managed Care & Specialty Pharmacy
Key finding: The COVID-19 pandemic and the social unrest pervading U.S. cities in response to the killings of George Floyd and other Black citizens at the hands of police are historically significant. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-10-28
Dysregulation of Endothelin-1: Implications for Health Disparities in Alzheimer's Disease
39/100 ✓ Peer-reviewed Disparities Journal of personalized medicine
Key finding: Endothelin-1 (ET-1) is a potent vasoconstrictive peptide that regulates smooth muscle, endothelial cell, and pericyte contractions that may result in cerebral vascular constriction, leading to cerebral hypoperfusion; over time, ET-1 may result in neuronal injury contributing to the pathology of AD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-10-28
Understanding dementia care in care home setting in China: An exploratory qualitative study
41/100 ✓ Peer-reviewed Health systems and care delivery Health & social care in the community
Key finding: Field notes of observations, nursing care records and interviews transcripts were triangulated for qualitative content analysis. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-10-28
Spatial hierarchical Bayes Small Area Model for disaggregated level crop acreage estimation
25/100 ✓ Peer-reviewed Risk factors The Indian Journal of Agricultural Sciences
Key finding: A pilot study conducted by ICAR- Indian Agricultural Statistics Research Institute attempts to estimate disaggregated level crop yield based on reduced number of Crop Cutting Experiments (CCEs) while crop acreage estimation has been done through sample survey approach. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-10-28
Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice
45/100 ✓ Peer-reviewed TREM2 and immune genetics Molecular neurodegeneration
Key finding: The Trem2 variant R47H, confers substantially elevated risk of developing late onset Alzheimer's disease, while NHD-linked Trem2 variants like Y38C, are associated with development of early onset dementia with white matter pathology. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-10-27
Plasma neurofilament light protein correlates with diffusion tensor imaging metrics in frontotemporal dementia
55/100 ✓ Peer-reviewed Biomarkers PloS one
Key finding: The results of both voxel-wise and tract specific analysis showed that increased plasma NfL concentration is associated with a reduction in fractional anisotropy (FA) in a widespread set of white matter tracts including the superior longitudinal fasciculus, the fronto-occipital fasciculus the anterior thalamic radiation and the dorsal cingulum bundle. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-10-27
Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer's Disease Genetics
66/100 ✓ Peer-reviewed Genetics Trends in neurosciences
Key finding: Genetic studies involving genome-wide association studies (GWAS) and meta-analysis have discovered numerous genomic loci associated with AD; however, the causal genes and variants remain unidentified in most loci. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-10-26
Dementia and the Critically Ill Older Adult
41/100 ✓ Peer-reviewed End-of-life care Critical care clinics
Key finding: As the elderly population grows, the incidence of dementia in hospitalized older adults increases and is associated with poor short-term and long-term outcomes. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-10-26
GLP-1 mimetics and cognition
40/100 ✓ Peer-reviewed Drug development Life sciences
Key finding: Recent evidence suggest that they also have additional effects modulating pathophysiologic pathways included in cognitive disorders.
Full summary, score breakdown and related studies → Original source
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2020-10-26
Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases
48/100 ✓ Peer-reviewed Genetics Nature genetics
Key finding: Genome-wide association studies of neurological diseases have identified thousands of variants associated with disease phenotypes.
Full summary, score breakdown and related studies → Original source
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2020-10-26
A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT
67/100 ✓ Peer-reviewed Mild cognitive impairment Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: This kMCT drink improved cognitive outcomes in MCI, at least in part by increasing blood ketone level.
Full summary, score breakdown and related studies → Original source
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2020-10-26
Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative
76/100 ✓ Peer-reviewed Getting a diagnosis Molecular psychiatry
Key finding: Despite being a multicenter study, plasma p-tau181 demonstrated high diagnostic accuracy to identify AD dementia (AUC = 85.3%; 95% CI, 81.4-89.2%), as well as to distinguish between Aβ- and Aβ+ individuals along the Alzheimer's continuum (AUC = 76.9%; 95% CI, 74.0-79.8%). +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-10-24
Neuronal Protein Farnesylation Regulates Hippocampal Synaptic Plasticity and Cognitive Function
41/100 ✓ Peer-reviewed Disease mechanisms Molecular neurobiology
Key finding: A follow-up study showed that systemic or forebrain neuron-specific deficiency of GGT leads to synaptic and cognitive deficits under physiological conditions. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-10-24
Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study
55/100 ✓ Peer-reviewed Long-term cohort studies Brain, behavior, and immunity
Key finding: Our understanding of risk factors for COVID‑19, including pre-existing medical conditions and genetic variations, is limited. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-10-23
Physical exercise protocols in animal models of Alzheimer's disease: a systematic review
73/100 ✓ Peer-reviewed Prevention trials Metabolic brain disease
Key finding: Finally, the main results presented in all studies were capable to reduce significantly AD consequences, such as reducing Aβ or pro-inflammatory proteins levels (100%). +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-10-23
Bi-directional association between epilepsy and dementia: The Framingham Heart Study
66/100 ✓ Peer-reviewed Long-term cohort studies Neurology
Key finding: We analyzed prospectively collected data in the Original and Offspring FHS cohorts. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-10-23
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease
56/100 ✓ Peer-reviewed TREM2 and immune genetics Nature communications
Key finding: While TREM2 mouse models have provided critical insight, the normal and disease-associated functions of TREM2 in human microglia remain unclear. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-10-23
Regional binding of tau and amyloid PET tracers in Down Syndrome autopsy brain tissue
34/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Molecular neurodegeneration
Key finding: Tau pathology is a major age-related event in Down syndrome with Alzheimer’s disease (DS-AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-10-23
Dementia in late-onset epilepsy: The Atherosclerosis Risk in Communities study
61/100 ✓ Peer-reviewed Disparities Neurology
Key finding: Of 9,033 ARIC participants with sufficient Medicare coverage data (4,980 [55.1%] female, 1993 [22.1%] Black), 671 met the definition of LOE. +1 more finding
Full summary, score breakdown and related studies → Original source
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