Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 11,776–11,800 of 27,380 studies, newest first · page 472 of 1096.
April 2020 4
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2020-04-01
The consistent burden in published estimates of delirium occurrence in medical inpatients over four decades: a systematic review and meta-analysis study
67/100 ✓ Peer-reviewed Caregiving Age and ageing
Key finding: The incidence and prevalence of delirium in hospitals appears to be stable, though publication bias may have masked true changes. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-04-01
Plasma tau, neurofilament light chain and amyloid-β levels and risk of dementia; a population-based cohort study
68/100 ✓ Peer-reviewed Getting a diagnosis Brain : a journal of neurology
Key finding: Moreover, biomarker plasma levels and rates of change over time of participants who developed Alzheimer's disease dementia during follow-up were compared with age and sex-matched dementia-free control subjects. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-04-01
Association of Neighborhood-Level Disadvantage With Cerebral and Hippocampal Volume
68/100 ✓ Peer-reviewed Prevention and risk JAMA neurology
Key finding: For cognitively unimpaired individuals, living in the most disadvantaged neighborhoods was associated with significantly lower cerebral volumes, after controlling for maximal premorbid (total intracranial) volume. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-04-01
Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β
64/100 ✓ Peer-reviewed Biomarkers JAMA neurology
Key finding: While APOEε4 is associated with increased amyloid-β burden, its association with cerebral tau pathology has been controversial. +4 more findings
Full summary, score breakdown and related studies → Original source
March 2020 21
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2020-03-31
Scalable diagnostic screening of mild cognitive impairment using AI dialogue agent
55/100 ✓ Peer-reviewed Cognitive tests and assessment Scientific reports
Key finding: To identify MCI status at the earliest possible point, recent studies have shown that linguistic markers such as word choice, utterance and sentence structures can potentially serve as preclinical behavioral markers.
Full summary, score breakdown and related studies → Original source
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2020-03-31
Elecsys CSF biomarker immunoassays demonstrate concordance with amyloid-PET imaging
53/100 ✓ Peer-reviewed Biomarkers Alzheimer's research & therapy
Key finding: Strong concordance between CSF biomarkers and Aβ-PET status was observed overall, including for cognitively normal participants, further strengthening the association between these markers of AD neuropathological burden for both developmental research studies and for use in clinical trials. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-03-31
Neurodegenerative Diseases - Is Metabolic Deficiency the Root Cause?
46/100 ✓ Peer-reviewed Inflammation and the immune system Frontiers in neuroscience
Key finding: They are characterized by an inexorable loss of a specific type of neurons. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-31
A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease
72/100 ✓ Peer-reviewed TREM2 and immune genetics Frontiers in immunology
Key finding: Large-scale genome-wide association studies point out several genetic variants- TREM2, CD33, PILRA, CR1, MS4A, CLU, ABCA7, EPHA1 , and HLA-DRB5-HLA-DRB1 -potentially linked to neuroinflammation. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-31
Cognitive impairment in the U.S.: Lifetime risk, age at onset, and years impaired
56/100 ✓ Peer-reviewed Disparities SSM - population health
Key finding: Our results paint a multi-dimensional picture of cognitive health, presenting the first comprehensive analysis of the burden of cognitive impairment for the U.S. population age 50 and older. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-31
Mechanisms of cognitive dysfunction in CKD
51/100 ✓ Peer-reviewed Prevention and risk Nature reviews. Nephrology
Key finding: Patients with CKD are at an increased risk (compared with the general population) of both dementia and its prodrome, mild cognitive impairment (MCI), which are characterized by deficits in executive functions, memory and attention. +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-30
The Genetics of Alzheimer's Disease in the Chinese Population
39/100 ✓ Peer-reviewed Risk genes beyond APOE International journal of molecular sciences
Key finding: In recent years, through the advancement of genome-wide association studies, second-generation gene sequencing technology, and their application in AD genetic research, more genetic loci associated with the risk for AD have been discovered, including KCNJ15, TREM2, and GCH1, which provides new ideas for the etiology and treatment of AD.
Full summary, score breakdown and related studies → Original source
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2020-03-30
Implications of Medicare Advantage for Patients With Alzheimer Disease and Related Dementias
37/100 ✓ Peer-reviewed Health systems and care delivery JAMA Network Open
Key finding: fewer functional limitations in the MA population, perhaps explaining why those patients had fewer health care visits.
Full summary, score breakdown and related studies → Original source
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2020-03-30
Health Care Utilization, Care Satisfaction, and Health Status for Medicare Advantage and Traditional Medicare Beneficiaries With and Without Alzheimer Disease and Related Dementias
64/100 ✓ Peer-reviewed Health systems and care delivery JAMA Network Open
Key finding: The sample included 47 100 Medicare beneficiaries (25 900 women [54.9%]; mean [SD] age, 72.2 [11.4] years). +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-27
Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress
39/100 ✓ Peer-reviewed Disease mechanisms Oxidative medicine and cellular longevity
Key finding: Furthermore, protein misfolding and/or alterations during protein synthesis results in inactive or toxic proteins, which may overload the degradation mechanisms. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-03-26
Relationship Between Exercise and Alzheimer's Disease: A Narrative Literature Review
41/100 ✓ Peer-reviewed Hippocampus size on brain scans Frontiers in neuroscience
Key finding: Most prospective studies have proven that physical inactivity is one of the most common preventable risk factors for developing AD and that higher physical activity levels are associated with a reduced risk of AD development. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-03-26
Augmenting Computerized Cognitive Training With Vortioxetine for Age-Related Cognitive Decline: A Randomized Controlled Trial
69/100 ✓ Peer-reviewed Prevention trials The American journal of psychiatry
Key finding: Vortioxetine may be beneficial for age-related cognitive decline when combined with cognitive training. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-26
Machine learning prediction of incidence of Alzheimer's disease using large-scale administrative health data
59/100 ✓ Peer-reviewed Digital health tools NPJ digital medicine
Key finding: The results were similar when the entire (unbalanced) samples were used.
Full summary, score breakdown and related studies → Original source
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2020-03-25
Neuropathological Mechanisms Associated with Pesticides in Alzheimer’s Disease
41/100 ✓ Peer-reviewed Risk factors Toxics
Key finding: Meanwhile, in vitro and animal models of AD have shed light on potential neuropathological mechanisms. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-25
Randomized placebo-controlled trial of the effects of aspirin on dementia and cognitive decline
78/100 ✓ Peer-reviewed Treatments Neurology
Key finding: There was no evidence that aspirin was effective in reducing risk of dementia, MCI, or cognitive decline. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-03-24
Fecal Microbiota Transplantation in Neurological Disorders
48/100 ✓ Peer-reviewed Disease mechanisms Frontiers in cellular and infection microbiology
Key finding: Of 541 identified studies, 34 were included in the analysis. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-24
Motoric Cognitive Risk Syndrome: A Risk Factor for Cognitive Impairment and Dementia in Different Populations
45/100 ✓ Peer-reviewed Clinical safety Annals of geriatric medicine and research
Key finding: The mean prevalence of MCR worldwide, including in a Korean cohort, was around 10%. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-24
Prevalence, Risk Factors, and Complications of Oropharyngeal Dysphagia in Older Patients with Dementia
69/100 ✓ Peer-reviewed Clinical safety Nutrients
Key finding: These results show that OD is very prevalent among patients with dementia and is associated with impaired functionality, malnutrition, respiratory infections, and increased mortality.
Full summary, score breakdown and related studies → Original source
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2020-03-24
Cognition Deficits in Parkinson's Disease: Mechanisms and Treatment
42/100 ✓ Peer-reviewed Mild cognitive impairment Parkinson's disease
Key finding: Of note, a patient with PD who suffers from cognitive impairment may harbour a statistically significantly higher risk of progressing toward dementia, which negatively affects their life expectancy and daily functioning and overall lowers the global quality of life.
Full summary, score breakdown and related studies → Original source
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2020-03-23
Emerging risk of environmental factors: insight mechanisms of Alzheimer's diseases
38/100 ✓ Peer-reviewed Risk factors Environmental science and pollution research international
Key finding: Environmental risk factors might play an important role in decelerating or accelerating AD progression. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-03-23
The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin
41/100 ✓ Peer-reviewed Brain scans and imaging Foods (Basel, Switzerland)
Key finding: Pharmacologically, quercetin has been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium , Babesia, and Theileria parasites. +4 more findings
Full summary, score breakdown and related studies → Original source
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