Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 9,151–9,175 of 27,380 studies, newest first · page 367 of 1096.
February 2022 25
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2022-02-26
"Aducanumab" making a comeback in Alzheimer's disease: An old wine in a new bottle
40/100 ✓ Peer-reviewed Treatments Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Key finding: The manuscript discusses the failure of anti-amyloid therapies in AD, that have accelerated the need to find a suitable therapeutic approach, followed by the discussion of timeline and impact of aducanumab in AD models, alongside the controversial judgement raising significant question. +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-02-25
Cohort Profile Update: The Study of Health in Pomerania (SHIP)
62/100 ✓ Peer-reviewed Drug development International Journal of Epidemiology
Key finding: Therefore, respective software was developed in-house.8,9 Segmentation results are then analysed for potential associations with disease risks and to establish reference intervals of organ size and function.10 SHIP is also used as a basis for meta-research with a particular focus on incidental MRI findings and their effects on study participants.11,12 With its large amount of standardized data and the option to internally replicate findings from SHIP-START using data of the independent SHIP-TREND, the project offers good opportunities to apply new bioinformatical tools to mine the data and gain new insights into risk factors and pathomechanisms. +3 more findings
Full summary, score breakdown and related studies → Original source
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2022-02-25
Racial/ethnic disparities in initiation and persistent use of anti-dementia medications
61/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Outcomes for acetylcholinesterase inhibitor (AChEI) treatment included (1) any new AChEI treatment during follow-up, and (2) persistence of treatment during follow-up categorized into: intermittent treatment (< 50% follow-ups reporting treatment), persistent (≥50% follow-ups), and always treated. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-02-25
Biofluid-based biomarkers for Alzheimer's disease-related pathologies: An update and synthesis of the literature
43/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The past few years have seen an explosion in sensitive and specific assays for cerebrospinal fluid (CSF) and blood biomarkers for Alzheimer's disease (AD) and related disorders, as well as some novel assays based on pathological seed-induced protein misfolding in patient samples. +3 more findings
Full summary, score breakdown and related studies → Original source
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2022-02-25
Racial differences in longitudinal Alzheimer's disease biomarkers among cognitively normal adults
58/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: Longitudinal racial differences in amyloid biomarkers are observed.
Full summary, score breakdown and related studies → Original source
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2022-02-24
Alzheimer's Disease Seen through the Eye: Ocular Alterations and Neurodegeneration
41/100 ✓ Peer-reviewed Brain scans and imaging International journal of molecular sciences
Key finding: There is increasing scientific evidence highlighting the similarities between the eye and other structures of the CNS, suggesting that knowledge acquired in eye research could be useful for research and diagnosis of AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2022-02-24
Identification of cognitively impaired patients at risk for development of Alzheimer’s disease dementia: an analysis of US Medicare claims data
32/100 ✓ Peer-reviewed Health systems and care delivery Expert Review of Pharmacoeconomics & Outcomes Research
Key finding: Predictors of an AD dementia diagnosis included age (odds ratio [OR], 1.71) and use of antipsychotics (OR, 2.50) and hypertension medication (OR, 1.25). +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-02-24
Allostatic-Interoceptive Overload in Frontotemporal Dementia
56/100 ✓ Peer-reviewed Digital health tools Biological psychiatry
Key finding: These results suggest that bvFTD may be characterized by an allostatic-interoceptive overload manifested in ongoing electrophysiological markers, brain atrophy, functional networks, and cognition. +3 more findings
Full summary, score breakdown and related studies → Original source
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2022-02-24
Addressing the disparities in dementia risk, early detection and care in Latino populations: Highlights from the second Latinos & Alzheimer's Symposium
53/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The Latino population in the United States is projected to have the steepest increase in Alzheimer's disease (AD) in the next 40 years, compared to other ethnic groups. +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-02-23
National General Health Screening Program in Korea: history, current status, and future direction
41/100 ✓ Peer-reviewed Disparities Precision and Future Medicine
Key finding: The main target diseases are cerebroand cardiovascular diseases, including hypertension, diabetes mellitus, dyslipidemia, obesity, and related health behaviors. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-02-23
Association Between Egg Consumption and Dementia Risk in the EPIC-Spain Dementia Cohort
57/100 ✓ Peer-reviewed Prevention and risk Frontiers in nutrition
Key finding: A total of 774 incident dementia cases were diagnosed and validated, of which 518 were Alzheimer's disease (AD). +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-02-23
Population attributable fraction of modifiable risk factors for dementia in Chile
48/100 ✓ Peer-reviewed Risk factors Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: The overall weighted PAF for modifiable risk factors was 45.8% (42.2% to 49.3%). +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-02-23
Diabetes: Risk factor and translational therapeutic implications for Alzheimer's disease
41/100 ✓ Peer-reviewed Drug development The European journal of neuroscience
Key finding: Animal models show that persistent hyperglycaemia results in chronic low-grade inflammation that may contribute to the development of neuroinflammation and accelerate the pathobiology of AD. +2 more findings
Full summary, score breakdown and related studies → Original source
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2022-02-23
Treatment with glucagon-like peptide-1 receptor agonists and incidence of dementia: Data from pooled double-blind randomized controlled trials and nationwide disease and prescription registers
74/100 ✓ Peer-reviewed Drug development Alzheimer's & dementia (New York, N. Y.)
Key finding: Treatment with GLP-1 RAs may provide a new opportunity to reduce the incidence of dementia in patients with type 2 diabetes. +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-02-23
Plasma biomarkers for Alzheimer's Disease in relation to neuropathology and cognitive change
52/100 ✓ Peer-reviewed Biomarkers Acta neuropathologica
Key finding: Comparing plasma biomarkers with pathology diagnoses and ratings, we found that P-tau181 (AUC = 0.856) and P-tau231 (AUC = 0.773) showed the strongest overall sensitivity and specificity for AD neuropathological change (ADNC). +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-02-23
Association of social isolation, loneliness and genetic risk with incidence of dementia: UK Biobank Cohort Study
55/100 ✓ Peer-reviewed Long-term cohort studies BMJ open
Key finding: Social isolation and loneliness have been associated with increased risk of dementia, but it is not known whether this risk is modified or confounded by genetic risk of dementia. +3 more findings
Full summary, score breakdown and related studies → Original source
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2022-02-23
Aducanumab Use in Symptomatic Alzheimer Disease Evidence in Focus [RETIRED]: A Report of the AAN Guidelines Subcommittee
16/100 ⚠ Retracted — do not rely on it Drug development Neurology
Key finding: The author panel systematically reviewed available clinical trial data detailing aducanumab use in individuals with early symptomatic Alzheimer disease. +3 more findings
Scored 26 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.
Full summary, score breakdown and related studies → Original source
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2022-02-23
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
64/100 ✓ Peer-reviewed Lewy body dementia Nature
Key finding: Two common intronic UNC13A polymorphisms strongly associated with amyotrophic lateral sclerosis and frontotemporal dementia risk overlap with TDP-43 binding sites. +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-02-23
TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A
64/100 ✓ Peer-reviewed Lewy body dementia Nature
Key finding: Single nucleotide polymorphisms in UNC13A are among the strongest hits associated with FTD and ALS in human genome-wide association studies 5,6 , but how those variants increase risk for disease is unknown. +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-02-23
Wearable and implantable devices for drug delivery: Applications and challenges
44/100 ✓ Peer-reviewed Digital health tools Biomaterials
Key finding: Microneedle-skin patches, wound healing patches, drug-eluting contact lenses, mouth guards, intra-vaginal rings, pharmaceutical jewelry, and drug-loaded self-care textiles are popular WDs explored in drug delivery. +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-02-23
Associations of Stages of Objective Memory Impairment With Amyloid PET and Structural MRI: The A4 Study
49/100 ✓ Peer-reviewed Biomarkers Neurology
Key finding: Participants had a mean age of 71.3 (SD 4.6) years; 40.6% were male; and 34.6% were APOE ε4 positive. +3 more findings
Full summary, score breakdown and related studies → Original source
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2022-02-22
Social Isolation and Nursing Leadership in Long-Term Care: Moving Forward After COVID-19
41/100 ✓ Peer-reviewed Risk factors The Nursing clinics of North America
Key finding: Nursing leaders have a responsibility to promote and facilitate social engagement and connectedness to mitigate social isolation in long-term care (LTC). +4 more findings
Full summary, score breakdown and related studies → Original source
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2022-02-22
Air Pollution, Ultrafine Particles, and Your Brain: Are Combustion Nanoparticle Emissions and Engineered Nanoparticles Causing Preventable Fatal Neurodegenerative Diseases and Common Neuropsychiatric Outcomes?
40/100 ✓ Peer-reviewed Risk factors Environmental science & technology
Key finding: Fossil fuel burning for transportation energy accounts for a significant fraction of urban air and climate pollution. +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-02-22
The pathogenic effects of particulate matter on neurodegeneration: a review
43/100 ✓ Peer-reviewed Risk factors Journal of biomedical science
Key finding: Epidemiological studies involving data from millions of patients or volunteers have associated PM with increased risk of dementia and Alzheimer's disease in the elderly and cognitive dysfunction and neurodegenerative pathology across all age groups, suggesting that PM may be a risk factor for neurodegenerative diseases. +1 more finding
Full summary, score breakdown and related studies → Original source
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2022-02-22
The Impact of COVID-19 Confinement on Cognition and Mental Health and Technology Use Among Socially Vulnerable Older People: Retrospective Cohort Study
81/100 ✓ Peer-reviewed Cognitive tests and assessment Journal of medical Internet research
Key finding: Our findings show that the first months of the outbreak did not significantly impact the cognition, quality of life, perceived health status, and depression of our study population when making comparisons with baseline assessments prior to the outbreak. +4 more findings
Full summary, score breakdown and related studies → Original source
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