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Protocol of Aerobic Exercise and Cognitive Health (REACH): A Pilot Study
Julian M Gaitán, Elizabeth A Boots, Ryan J Dougherty, Yue Ma, Dorothy F Edwards, Carol C Mitchell, Bradley T Christian, Dane B Cook et al.. Journal of Alzheimer's disease reports, 2020-05-02
Topic: Brain imaging, connectivity and assessment
A growing body of evidence supports that aerobic exercise can decrease the risk of future cognitive impairment and Alzheimer's disease (AD). There is a pressing need to rigorously determine whether cognitively normal yet at-risk individuals stand to benefit from the protective effects of exercise. The present study will test the feasibility of an aerobic exercise intervention in such a population and inform the design of a larger-scale randomized, controlled trial examining the effect of aerobic exercise on biomarkers of AD in late-middle-aged, at-risk individuals. This was a single-site, 1 : 1 block-randomized, parallel, two-arm trial. Cognitively normal participants aged 45-80 with documentation of familial and genetic AD risk factors were randomly assigned to one of two interventions. The Usual Physical Activity group was provided educational materials about exercise. The Enhanced Physical Activity intervention delivered 26 weeks of individualized and supervised aerobic exercise. Exercise duration and intensity were incrementally increased to 150 min/week and 70-80% of heart rate reserve, respectively. Retention and adherence were measured to assess study feasibility. In addition, pre- and post- intervention differences between the two arms were evaluated for cardiorespiratory fitness, physical activity, brain glucose metabolism, cerebral structure, vascular health, memory, executive function, and mood. Data from randomized controlled trials of exercise training are needed to identify the proper exercise prescription for reducing accumulation of AD biomarkers in cognitively normal individuals. The current trial will contribute to filling that gap while informing the design of large-scale trials.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Gaitán, J. M., Boots, E. A., Dougherty, R. J., Ma, Y., Edwards, D. F., Mitchell, C. C., et al. (2020). Protocol of Aerobic Exercise and Cognitive Health (REACH): A Pilot Study. Journal of Alzheimer's disease reports. https://doi.org/10.3233/adr-200180
Vancouver
Gaitán JM, Boots EA, Dougherty RJ, Ma Y, Edwards DF, Mitchell CC, et al. Protocol of Aerobic Exercise and Cognitive Health (REACH): A Pilot Study. Journal of Alzheimer's disease reports. 2020. doi:10.3233/adr-200180. PMID: 32587945.
BibTeX
@article{gaitan2020-32587945,
author = {Gaitán, Julian M and Boots, Elizabeth A and Dougherty, Ryan J and Ma, Yue and Edwards, Dorothy F and Mitchell, Carol C and Christian, Bradley T and Cook, Dane B and others},
title = {{Protocol of Aerobic Exercise and Cognitive Health (REACH): A Pilot Study}},
journal = {Journal of Alzheimer's disease reports},
year = {2020},
doi = {10.3233/adr-200180},
pmid = {32587945},
url = {https://doi.org/10.3233/adr-200180}
}
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Key findings
- Exercise duration and intensity were incrementally increased to 150 min/week and 70-80% of heart rate reserve, respectively.
- Retention and adherence were measured to assess study feasibility.
- In addition, pre- and post- intervention differences between the two arms were evaluated for cardiorespiratory fitness, physical activity, brain glucose metabolism, cerebral structure, vascular health, memory, executive function, and mood.
- Data from randomized controlled trials of exercise training are needed to identify the proper exercise prescription for reducing accumulation of AD biomarkers in cognitively normal individuals.
- The current trial will contribute to filling that gap while informing the design of large-scale trials.
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Study details
- Evidence strengthHigh
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and studied in people because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 27 of the 56 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease reports) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32587945) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 27 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 27 of the 56 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
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