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43/100

✓ Peer-reviewed alzhub usefulness score 43 out of 100. Biomarkers

Topic: Amyloid, tau and blood-test diagnosis

Of the 1,193 CI patients, 860 (72.1%) were amyloid-positive. The prevalence of amyloid positivity in AD and MCI patients was 86.8% (833/960) and 9.7% (14/144), respectively. In FTD patients, the prevalence of β-amyloid deposits was 5.6% (2/36). In the 4 corticobasal syndrome patients, 2 were amyloid-positive. Three of the 5 patients with dementia with Lewy bodies showed amyloid positivity, as did 6 of the 29 vascular dementia (20.7%) patients. The ApoEε4 allele frequency was significantly increased in amyloid-positive CI patients (30.5%) as compared with other amyloid-negative CI patients (14%) or controls (7.3%). Amyloid imaging may potentially be the most helpful parameter for differential diagnosis in dementia, particularly to distinguish between AD and FTD. Amyloid PET can be used in conjunction with the ApoEε4 allele genetic risk test for amyloid deposits.

Key findings

Of the 1,193 CI patients, 860 (72.1%) were amyloid-positive.
The prevalence of amyloid positivity in AD and MCI patients was 86.8% (833/960) and 9.7% (14/144), respectively.
In FTD patients, the prevalence of β-amyloid deposits was 5.6% (2/36).
In the 4 corticobasal syndrome patients, 2 were amyloid-positive.
Three of the 5 patients with dementia with Lewy bodies showed amyloid positivity, as did 6 of the 29 vascular dementia (20.7%) patients.

Why it matters

In 1,193 people with cognitive impairment, amyloid PET was positive in 86.8% of those with Alzheimer's disease and in only 5.6% of those with frontotemporal dementia, and the APOE ε4 allele was more frequent in amyloid-positive cases. This supports amyloid imaging for differential diagnosis, not for treating, curing or preventing Alzheimer's disease.

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Study details

Effect size72.1%; 86.8%; 9.7%
Evidence strengthLow

How this study scored 43/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
Journal's citation record	2 / 4	Journal of Nuclear Medicine: journal h-index 230 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2020 — within 10 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	3 / 7	Cited 31 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	3.9 citations a year over 8 year(s) since 2020
Impact for its field and year	3 / 6	Cited 3.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 4 other studies in this library
Still being cited	1 / 4	Cited 11 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Yong Ji: h-index 28 (OpenAlex, whole career)
Institution's track record	1 / 3	Fudan University: institution h-index 954 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 10 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 32385166)
Free to read	0 / 2	Behind a paywall — scores zero
Total	43 / 100	—

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APA 7th

Shi, Z., Fu, L. P., Zhang, N., Zhao, X., Liu, S., Zuo, C., et al. (2020). Amyloid PET in Dementia Syndromes: A Chinese Multicenter Study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. https://doi.org/10.2967/jnumed.119.240325

Vancouver

Shi Z, Fu LP, Zhang N, Zhao X, Liu S, Zuo C, et al. Amyloid PET in Dementia Syndromes: A Chinese Multicenter Study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2020. doi:10.2967/jnumed.119.240325. PMID: 32385166.

BibTeX

@article{shi2020-32385166,
  author  = {Shi, Z. and Fu, L. P. and Zhang, N. and Zhao, X. and Liu, S. and Zuo, C. and Cai, L. and Wang, Y. and others},
  title   = {{Amyloid PET in Dementia Syndromes: A Chinese Multicenter Study}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2020},
  doi     = {10.2967/jnumed.119.240325},
  pmid    = {32385166},
  url     = {https://doi.org/10.2967/jnumed.119.240325}
}

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