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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 11,301–11,325 of 27,380 studies, newest first · page 453 of 1096.

August 2020 25

  1. 2020-08-16

    Erythrocytes as markers of oxidative stress related pathologies

    ✓ Peer-reviewed Down syndrome and Alzheimer's Mechanisms of ageing and development

    Key finding: During inflammatory response RBC, as a part of haematological system, are exposed to circulating inflammatory mediators and related oxidative stress. +4 more findings

    Full summary, score breakdown and related studies → Original source

  2. 2020-08-14

    Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy

    ✓ Peer-reviewed Long-term cohort studies Acta neuropathologica

    Key finding: All subjects (n = 495) had autopsy-proven TDP-43 proteinopathy as an inclusion criterion. +3 more findings

    Full summary, score breakdown and related studies → Original source

  3. 2020-08-14

    Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition

    ✓ Peer-reviewed TREM2 and immune genetics Journal of neuroinflammation

    Key finding: Triggering receptor expressed on myeloid cell-2 (TREM2) is a lipid and lipoprotein binding receptor expressed by cells of myeloid origin. +3 more findings

    Full summary, score breakdown and related studies → Original source

  4. 2020-08-13

    Education and Cognitive Decline: An Integrative Analysis of Global Longitudinal Studies of Cognitive Aging

    ✓ Peer-reviewed Risk factors The journals of gerontology. Series B, Psychological sciences and social sciences

    Key finding: This study replicated research showing that education was positively associated with cognition at baseline. +4 more findings

    Full summary, score breakdown and related studies → Original source

  5. 2020-08-13

    ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

    ✓ Peer-reviewed Inflammation and the immune system Antioxidants (Basel, Switzerland)

    Key finding: Protein aggregation and neuronal damage result in the activation of disease-associated microglia (DAM) via damage-associated molecular patterns (DAMPs). +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2020-08-13

    Microglia Gone Awry: Linking Immunometabolism to Neurodegeneration

    ✓ Peer-reviewed TREM2 and immune genetics Frontiers in cellular neuroscience

    Key finding: The housekeeping and defensive functions of microglia, such as surveying the brain parenchyma and phagocytosis of neuronal debris after injury, are important for brain homeostasis and immunity. +3 more findings

    Full summary, score breakdown and related studies → Original source

  7. 2020-08-12

    A Comprehensive Evaluation of the Process of Copying a Complex Figure in Early- and Late-Onset Alzheimer Disease: A Quantitative Analysis of Digital Pen Data

    ✓ Peer-reviewed Cognitive tests and assessment Journal of medical Internet research

    Key finding: The digitalized complex figure test evaluated copying performance quantitatively and further elucidated the patients' ongoing process during copying.

    Full summary, score breakdown and related studies → Original source

  8. 2020-08-12

    Discontinuation of Statins in Veterans Admitted to Nursing Homes near the End of Life

    ✓ Peer-reviewed End-of-life care Journal of the American Geriatrics Society

    Key finding: Most veterans with LLE/AD taking statins for secondary prevention do not discontinue statins following CLC admission. +1 more finding

    Full summary, score breakdown and related studies → Original source

  9. 2020-08-12

    Aducanumab, gantenerumab, BAN2401, and ALZ-801-the first wave of amyloid-targeting drugs for Alzheimer's disease with potential for near term approval

    ✓ Peer-reviewed Hippocampus size on brain scans Alzheimer's research & therapy

    Key finding: Aducanumab and BAN2401 showed significant efficacy on both clinical and biomarker outcomes; gantenerumab showed significant biomarker effects, with no clinical efficacy reported to date; and ALZ-801 showed significant clinical effects in the high-risk population of patients homozygous for the ε4 allele of apolipoprotein E gene (APOE4) and a dose-dependent preservation of hippocampal volume. +3 more findings

    Full summary, score breakdown and related studies → Original source

  10. 2020-08-12

    The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment: A Pilot Feasibility Study

    ✓ Peer-reviewed Prevention trials Clinical interventions in aging

    Key finding: MBSR is well-accepted potentially promising intervention with positive effect on cognition, depressive symptoms and immunological profile. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2020-08-12

    Profile of MIF in Developing Hippocampus: Association With Cell Proliferation and Neurite Outgrowth

    ✓ Peer-reviewed Biomarkers Frontiers in molecular neuroscience

    Key finding: Previous studies have shown that MIF is expressed in neocortex, hippocampus, hypothalamus, cerebellum, and spinal cord in adult mice. +4 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2020-08-11

    Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme

    ✓ Peer-reviewed Disease mechanisms Acta neuropathologica

    Key finding: Chronic traumatic encephalopathy (CTE) is a tauopathy associated with repetitive head impacts (RHI) that has been neuropathologically diagnosed in American football players and other contact sport athletes. +4 more findings

    Full summary, score breakdown and related studies → Original source

  13. 2020-08-11

    Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer

    ✓ Peer-reviewed TREM2 and immune genetics Cell

    Key finding: Here, we introduce INs-seq, an integrated technology for massively parallel recording of single-cell RNA sequencing (scRNA-seq) and intracellular protein activity. +3 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2020-08-11

    TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

    ✓ Peer-reviewed TREM2 and immune genetics Cell

    Key finding: TREM2 is a myeloid receptor that transmits intracellular signals that sustain microglial responses during Alzheimer's disease. +3 more findings

    Full summary, score breakdown and related studies → Original source

  15. 2020-08-11

    Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention

    ✓ Peer-reviewed Down syndrome and Alzheimer's Progress in neurobiology

    Key finding: By investigating human DS frontal cortices, we found early and sustained PERK activation associated with the induction of eIF2α and ATF4 downstream signals. +1 more finding

    Full summary, score breakdown and related studies → Original source

  16. 2020-08-11

    Sex differences in CSF biomarkers vary by Alzheimer disease stage and APOE ε4 genotype

    ✓ Peer-reviewed Genetics Neurology

    Key finding: Within APOE ε4 carriers, sex differences in CSF p-Tau are more evident in early disease stages, whereas for APOE ε4 noncarriers, sex differences are more evident in advanced disease stages. +2 more findings

    Full summary, score breakdown and related studies → Original source

  17. 2020-08-10

    Epigenome-wide analyses identify DNA methylation signatures of dementia risk

    ✓ Peer-reviewed Genetics Alzheimer's & dementia (Amsterdam, Netherlands)

    Key finding: AD genetic risk and two dementia risk scores were associated with differential methylation. +3 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2020-08-10

    Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation

    ✓ Peer-reviewed TREM2 and immune genetics EMBO molecular medicine

    Key finding: Both cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2), a biomarker of microglia activation, and microglia PET are increased in AD; however, whether an increase in these biomarkers is associated with reduced amyloid-beta (Aβ) accumulation remains unclear. +3 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2020-08-10

    Study protocol: pragmatic randomized control trial of my tools 4 care- in care (MT4C-in care) a web-based tool for family Carers of persons with dementia residing in long term care

    ✓ Peer-reviewed Treatments BMC geriatrics

    Key finding: Data collection will begin in four Canadian provinces (Alberta, Manitoba, Ontario and Saskatchewan) in February 2020 and is expected to be completed in June 2021. +2 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2020-08-09

    Post-mortem analyses of PiB and flutemetamol in diffuse and cored amyloid-β plaques in Alzheimer's disease

    ✓ Peer-reviewed Brain scans and imaging Acta neuropathologica

    Key finding: Fixed tissue sections of frontal cortex and caudate from 10 of the AD cases were processed for microscopy using fluorescent derivatives of flutemetamol (cyano-flutemetamol) and PiB (cyano-PiB) and compared to Aβ immunohistochemistry and pan-amyloid (X-34) histology. +3 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2020-08-09

    Role of tau protein in Alzheimer's disease: The prime pathological player

    ✓ Peer-reviewed Disease mechanisms International journal of biological macromolecules

    Key finding: With population aging worldwide, there is an indispensable need for treatment strategies that can potentially manage this developing dementia. +4 more findings

    Full summary, score breakdown and related studies → Original source

  22. 2020-08-09

    Cuing Prospective Memory With Smartphone-Based Calendars in Alzheimer's Disease

    ✓ Peer-reviewed Risk factors Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

    Key finding: Events were cued either by the paper- or smartphone-based calendar. we observed fewer omissions of prospective events in the smartphone-based calendar group than in the paper-based calendar group. our study suggests positive effects of smartphone calendar applications on prospective memory in AD.

    Full summary, score breakdown and related studies → Original source

  23. 2020-08-09

    TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

    ✓ Peer-reviewed TREM2 and immune genetics Acta neuropathologica

    Key finding: Microglia are critical for the clearance of myelin debris in areas of demyelination, a key step to allow remyelination. +3 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2020-08-08

    Estrogen-dependent hippocampal wiring as a risk factor for age-related dementia in women

    ✓ Peer-reviewed Prevention trials Progress in neurobiology

    Key finding: The hippocampus of cognitively impaired subjects tends to shrink with age; however, in many cases, this can be prevented by exercise or cognitive training, suggesting that if you do not use the hippocampus you lose it. +2 more findings

    Full summary, score breakdown and related studies → Original source

  25. 2020-08-06

    Direct Medical Costs of Dementia With Lewy Bodies by Disease Complexity

    ✓ Peer-reviewed Costs and economics Journal of the American Medical Directors Association

    Key finding: In both databases, total healthcare resource utilization and costs increased with number of core features. +3 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →