Newest studies
Every summary in our library, newest first, as a dated timeline.
Showing 11,276–11,300 of 27,380 studies, newest first · page 452 of 1096.
August 2020 25
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2020-08-21
Multimodal in vivo and postmortem assessments of tau in Lewy body disorders
50/100 ✓ Peer-reviewed Brain scans and imaging Neurobiology of aging
Key finding: Higher retention was associated with higher CSF total-tau levels (p = 0.04), poorer domain-specific cognitive performance (p = 0.02-0.04), and greater severity of neuropathological tau in corresponding regions.
Full summary, score breakdown and related studies → Original source
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2020-08-21
A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders
45/100 ✓ Peer-reviewed Genetics Nature communications
Key finding: We show that the common genetic risk for Parkinson's disease (PD) is associated with dopaminergic neuron (DaN)-specific gene expression, including mitochondrial functioning, protein folding and ubiquitination pathways. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-08-21
The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia
43/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Antioxidants (Basel, Switzerland)
Key finding: Down syndrome (DS) is the most common genetic cause of intellectual disability that is associated with an increased risk to develop early-onset Alzheimer-like dementia (AD). +2 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-20
Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study
66/100 ✓ Peer-reviewed Tau biomarkers PLoS medicine
Key finding: The ε4 allele of apolipoprotein E (APOE) gene and increasing age are two of the most important known risk factors for developing Alzheimer disease (AD). +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-20
Mitochondrial Dysfunction and Alzheimer's Disease: Role of Microglia
46/100 ✓ Peer-reviewed Risk genes beyond APOE Frontiers in aging neuroscience
Key finding: The neurodegenerative disease became known as Alzheimer's disease (AD) and is the most common cause of dementia worldwide. +3 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-20
The Role of EEG in the Diagnosis, Prognosis and Clinical Correlations of Dementia with Lewy Bodies-A Systematic Review
63/100 ✓ Peer-reviewed Digital health tools Diagnostics (Basel, Switzerland)
Key finding: We included 43 studies comparing EEG in DLB with other diagnoses, 42 of them included a comparison of DLB with AD, 10 studies compared DLB with Parkinson's disease dementia, and 6 studies compared DLB with other dementias. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-19
Continuity of care and health care cost among community-dwelling older adult veterans living with dementia
50/100 ✓ Peer-reviewed Costs and economics Health services research
Key finding: Mean BBC in FY 2014 was 0.32; mean total cost in FY 2015 was $35 425. +3 more findings
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2020-08-19
User-Centered Design and Evaluation of a Web-Based Decision Aid for Older Adults Living With Mild Cognitive Impairment and Their Health Care Providers: Mixed Methods Study
44/100 ✓ Peer-reviewed Digital health tools Journal of medical Internet research
Key finding: The thematic analysis revealed 3 major issues. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-08-19
Digital biomarker-based individualized prognosis for people at risk of dementia
55/100 ✓ Peer-reviewed Digital health tools Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: Digital biomarker prognostic models can be a useful tool to assist large-scale population screening for the early detection of cognitive impairment and patient monitoring over time.
Full summary, score breakdown and related studies → Original source
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2020-08-19
The Effects of Age-Related Hearing Loss on the Brain and Cognitive Function
47/100 ✓ Peer-reviewed Prevention and risk Trends in neurosciences
Key finding: Recently, hearing loss has been identified as potentially the most modifiable risk factor for dementia. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-18
Informal and formal care among persons with dementia immediately before nursing home admission
59/100 ✓ Peer-reviewed Caregiving BMC geriatrics
Key finding: A total of 395 persons with dementia were included. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-18
Education, intelligence, and amyotrophic lateral sclerosis: A Mendelian randomization study
39/100 ✓ Peer-reviewed Risk factors Annals of clinical and translational neurology
Key finding: Genetically predisposition to longer educational attainment and harder math class taken were associated with significantly lower statistical odds ratio of ALS. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-18
Galantamine-Memantine combination in the treatment of Alzheimer's disease and beyond
46/100 ✓ Peer-reviewed Treatments Psychiatry research
Key finding: The objective of this review is to highlight the potential of the galantamine-memantine combination to conduct randomized controlled trials (RCTs) in AD. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-18
Disease duration in autosomal dominant familial Alzheimer disease: A survival analysis
39/100 ✓ Peer-reviewed Risk genes beyond APOE Neurology. Genetics
Key finding: Estimated mean survival was 11.6 (10.4-12.9) years and was similar for APP and PSEN1 mutations. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-18
Blood-based biomarkers for Alzheimer's pathology and the diagnostic process for a disease-modifying treatment: Projecting the impact on the cost and wait times
45/100 ✓ Peer-reviewed Biomarkers Alzheimer's & dementia (Amsterdam, Netherlands)
Key finding: The combination BBBM with MMSE is projected to increase the efficiency and value of the triage process for DMT eligibility.
Full summary, score breakdown and related studies → Original source
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2020-08-18
P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice
41/100 ✓ Peer-reviewed Disease mechanisms Molecular neurodegeneration
Key finding: The oral administration of P2RX7 inhibition mitigates disease phenotypes in P301S mice, likely by suppressing release of microglial exosomes. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-18
Device-assessed physical activity and sedentary behavior in a community-based cohort of older adults
56/100 ✓ Peer-reviewed Disparities BMC public health
Key finding: Our recruitment rate demonstrates the feasibility of cohort participants to wear two devices that measure sedentary time and physical activity.
Full summary, score breakdown and related studies → Original source
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2020-08-18
Towards early disease modification of Parkinson's disease: a review of lessons learned in the Alzheimer field
45/100 ✓ Peer-reviewed Treatments Journal of neurology
Key finding: To identify people in this early disease stage, criteria for 'prodromal PD' have been proposed-describing people with one or more specific features that jointly constitute a variably increased risk of developing clinically manifest PD. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-08-18
Evaluating resting-state BOLD variability in relation to biomarkers of preclinical Alzheimer's disease
44/100 ✓ Peer-reviewed Biomarkers Neurobiology of aging
Key finding: Recent functional magnetic resonance imaging studies have demonstrated that moment-to-moment variability in the blood oxygen level-dependent (BOLD) signal is related to age differences, cognition, and symptomatic Alzheimer's disease (AD).
Full summary, score breakdown and related studies → Original source
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2020-08-17
Perspective on the "African American participation in Alzheimer disease research: Effective strategies" workshop, 2018
43/100 ✓ Peer-reviewed Disparities Alzheimer's & dementia : the journal of the Alzheimer's Association
Key finding: The Washington University School of Medicine Knight Alzheimer Disease Research Center's "African American Participation in Alzheimer Disease Research: Effective Strategies" Workshop convened to address a major limitation of the ongoing scientific progress regarding Alzheimer's disease and related dementias (ADRD): participants in most ADRD research programs overwhelmingly have been limited to non-Hispanic white persons, thus precluding knowledge as to how ADRD may be represented in non-white individuals. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-08-17
Repurposed agents in the Alzheimer's disease drug development pipeline
39/100 ✓ Peer-reviewed Drug development Alzheimer's research & therapy
Key finding: We identified 53 clinical trials involving 58 FDA-approved agents. +4 more findings
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2020-08-17
QT interval prolongation and Torsades de Pointes with donepezil, rivastigmine and galantamine
46/100 ✓ Peer-reviewed Treatments Therapeutic advances in drug safety
Key finding: A total of 13 case reports were found (10 for donepezil, 2 for galantamine and 1 for rivastigmine) with rate corrected QT interval (QTc) prolongation. +4 more findings
Full summary, score breakdown and related studies → Original source
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2020-08-17
The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability
41/100 ✓ Peer-reviewed Disease mechanisms Cells
Key finding: An altered intestinal permeability, a sign of a perturbed barrier function, has during the last decade been associated with several chronic conditions, including diseases originating in the gastrointestinal tract but also diseases such as Alzheimer and Parkinson disease.
Full summary, score breakdown and related studies → Original source
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2020-08-17
Using the COM-B model to identify barriers and facilitators towards adoption of a diet associated with cognitive function (MIND diet)
43/100 ✓ Peer-reviewed Prevention trials Public health nutrition
Key finding: This study provides insight into the personal, social and environmental factors that participants report as barriers and facilitators to the adoption of the MIND diet among middle-aged adults living in the UK. +1 more finding
Full summary, score breakdown and related studies → Original source
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2020-08-17
Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer's disease-related inhibitory circuit dysfunction in adults with Down syndrome
53/100 ✓ Peer-reviewed Down syndrome and Alzheimer's Molecular neurodegeneration
Key finding: Compared to controls, mean CSF NPTX2 levels were lower in DS at all AD stages; aDS (0.6-fold, adj.p 0.07). +1 more finding
Full summary, score breakdown and related studies → Original source
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