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Newest studies

Every summary in our library, newest first, as a dated timeline.

What "newest" means here

The most recent study in this library is dated 2026-11-01 (Paths of Aging Minds: Health Journeys of Older Adults with Mild Cognitive Impairment). This is our summary library, not a news wire — it is added to in batches, so the newest entry may not be the newest paper published anywhere.

Entries are sorted strictly by publication date, newest first. 26489 of the 27380 entries carry a full day-level date. 65 have no date recorded at all and are placed by publication year, at the start of that year; those are marked "no date recorded" below so you can see where the ordering is a best effort rather than a fact.

Prefer a reader? Subscribe to the Atom feed. Want them sorted by subject or by score instead? Browse the research library.

Showing 10,051–10,075 of 27,380 studies, newest first · page 403 of 1096.

June 2021 25

  1. 2021-06-30

    Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

    ✓ Peer-reviewed Disease mechanisms Nature reviews. Drug discovery

    Key finding: Although numerous small molecules evaluated as antioxidants have exhibited therapeutic potential in preclinical studies, clinical trial results have been disappointing.

    Full summary, score breakdown and related studies → Original source

  2. 2021-06-30

    Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

    ✓ Peer-reviewed Disease mechanisms Ageing research reviews

    Key finding: We conclude that WD can trigger AD by acceleration of inflammaging, and that BBB impairment induced by metabolic and systemic inflammation play the central role in this process.

    Full summary, score breakdown and related studies → Original source

  3. 2021-06-30

    A Critical Review of the Study of Neuroprotective Diets to Reduce Cognitive Decline

    ✓ Peer-reviewed Prevention trials Nutrients

    Key finding: This paper analyzed five Randomized Clinical Trials (RCTs) (from 2000 to 2021) and 27 observational studies (from 2010 to 2021) focused on the link between cognitive health and the Mediterranean/DASH/MIND diets to identify gaps and challenges that could lead to inconsistent results.

    Full summary, score breakdown and related studies → Original source

  4. 2021-06-29

    NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration

    ✓ Peer-reviewed Inflammation and the immune system International journal of molecular sciences

    Key finding: Amyloid beta (Aβ)-induced abnormal neuroinflammation is recognized as a major pathological feature of Alzheimer's disease (AD), which results in memory impairment.

    Full summary, score breakdown and related studies → Original source

  5. 2021-06-29

    Improving the Utility of Polygenic Risk Scores as a Biomarker for Alzheimer's Disease

    ✓ Peer-reviewed Genetics Cells

    Key finding: Significant research and investment focuses on state-of-the-art genomic and metagenomic analyses in the burgeoning field of Precision (or Personalized) Medicine with genome-wide-association-studies (GWAS) helping in this direction by linking patient genotypes at specific polymorphic sites (single-nucleotide polymorphisms, SNPs) to the specific phenotype. +2 more findings

    Full summary, score breakdown and related studies → Original source

  6. 2021-06-29

    Interactions between Apolipoprotein E Metabolism and Retinal Inflammation in Age-Related Macular Degeneration

    ✓ Peer-reviewed Genetics Life (Basel, Switzerland)

    Key finding: The APOE gene, encoding apolipoprotein E (APOE), is a major genetic risk factor for AMD, with the APOE2 allele conferring increased risk and APOE4 conferring reduced risk, in comparison to the wildtype APOE3.

    Full summary, score breakdown and related studies → Original source

  7. 2021-06-29

    A tablet-based intervention for activating nursing home residents with dementia: results from a cluster-randomized controlled trial

    ✓ Peer-reviewed Cognitive tests and assessment International psychogeriatrics

    Key finding: Levels of apathy decreased slightly in both groups (mean decrease in AES-I of .61 points, 95% CI -3.54, 2.33 for TBI and .36 points, 95% CI -3.27, 2.55 for CAS). +4 more findings

    Full summary, score breakdown and related studies → Original source

  8. 2021-06-29

    Associations of longitudinal plasma p-tau181 and NfL with tau-PET, Aβ-PET and cognition

    ✓ Peer-reviewed Biomarkers Journal of neurology, neurosurgery, and psychiatry

    Key finding: P-tau and NfL behave differently within the same individuals over time and may therefore offer complementary diagnostic information.

    Full summary, score breakdown and related studies → Original source

  9. 2021-06-29

    Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature

    ✓ Peer-reviewed Disease mechanisms Acta neuropathologica communications

    Key finding: Histological analyses (AT8, TDP-43, pTDP-43, NeuN, GFAP, Iba-1, MBP, SMI-312, Prussian blue, IgG, βAPP, alpha-synuclein) were conducted at 1 week, 4 weeks, and 24 weeks after rTBI and compared to sham operated controls.

    Full summary, score breakdown and related studies → Original source

  10. 2021-06-28

    Effects of restriction of activities and social isolation on risk of dementia in the community

    ✓ Peer-reviewed Risk factors International psychogeriatrics

    Key finding: Both Restriction (HR = 2.22, 95% CI [1.42, 3.47], P < .001) and Isolation (HR = 1.78, 95% CI [1.17, 2.70], P = 0.007) were associated with episodic memory and incident dementia, controlling for age, sex, and education. +4 more findings

    Full summary, score breakdown and related studies → Original source

  11. 2021-06-28

    Plasma neurofilament light chain is associated with cognitive decline in non-dementia older adults

    ✓ Peer-reviewed Biomarkers Scientific reports

    Key finding: Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. +3 more findings

    Full summary, score breakdown and related studies → Original source

  12. 2021-06-28

    Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease

    ✓ Peer-reviewed Treatments Molecular biology reports

    Key finding: Hence, it is concluded that novel therapeutic strategies are required to discover and develop therapeutic agents to fight against the century old AD.

    Full summary, score breakdown and related studies → Original source

  13. 2021-06-28

    Associations of GP practice characteristics with the rate of ambulatory care sensitive conditions in people living with dementia in England: an ecological analysis of routine data

    ✓ Peer-reviewed Risk factors BMC Health Services Research

    Key finding: The rate of hospital admissions are variable between GP practices, with deprivation and being admitted from home as risk factors for admission for ACSC and non-ACSC admissions. +4 more findings

    Full summary, score breakdown and related studies → Original source

  14. 2021-06-28

    VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome

    ✓ Peer-reviewed Down syndrome and Alzheimer's Alzheimer's research & therapy

    Key finding: There is an urgent need for objective markers of Alzheimer's disease (AD)-related cognitive impairment in people with Down syndrome (DS) to improve diagnosis, monitor disease progression, and assess response to disease-modifying therapies.

    Full summary, score breakdown and related studies → Original source

  15. 2021-06-25

    The Effectiveness of Computerized Cognitive Training Combined With Whole Body Cryotherapy in Improving Cognitive Functions in Older Adults. A Case Control Study

    ✓ Peer-reviewed Cognitive tests and assessment Frontiers in psychiatry

    Key finding: The results show evidence for increased performance in the assessment of general cognitive functioning in both EGs (p ≤ 0.05). +4 more findings

    Full summary, score breakdown and related studies → Original source

  16. 2021-06-25

    Feasibility of Repeated Assessment of Cognitive Function in Older Adults Using a Wireless, Mobile, Dry-EEG Headset and Tablet-Based Games

    ✓ Peer-reviewed Cognitive tests and assessment Frontiers in psychiatry

    Key finding: Electroencephalography (EEG) recordings, both resting and in combination with targeted cognitive tasks, have demonstrated utility in tracking disease state and therapy response in a range of conditions from schizophrenia to Alzheimer's disease. +1 more finding

    Full summary, score breakdown and related studies → Original source

  17. 2021-06-25

    Histological and imunohistochemical alterations of hippocampus and prefrontal cortex in a rat model of Alzheimer like-disease with a preferential role of the flavonoid "hesperidin"

    ✓ Peer-reviewed Biomarkers Journal of molecular histology

    Key finding: AD rats displayed memory impairment in the behavioural paradigm with a concomitant increase of serum TNF-α and IL-1β, while IL-10 decreased significantly. +2 more findings

    Full summary, score breakdown and related studies → Original source

  18. 2021-06-24

    Maintaining and improving mouth care for care home residents: A participatory research project

    ✓ Peer-reviewed Health systems and care delivery International journal of older people nursing

    Key finding: We conducted a participatory research project to address this important area of care. +4 more findings

    Full summary, score breakdown and related studies → Original source

  19. 2021-06-24

    Chemical-Mediated Targeted Protein Degradation in Neurodegenerative Diseases

    ✓ Peer-reviewed Disease mechanisms Life (Basel, Switzerland)

    Key finding: Recently, the degradation of target proteins by small molecules has emerged as a new therapeutic modality and has garnered the interest of the researchers in the pharmaceutical industry. +4 more findings

    Full summary, score breakdown and related studies → Original source

  20. 2021-06-24

    White matter plasticity in healthy older adults: The effects of aerobic exercise

    ✓ Peer-reviewed Prevention trials NeuroImage

    Key finding: White matter deterioration is associated with cognitive impairment in healthy aging and Alzheimer's disease. +2 more findings

    Full summary, score breakdown and related studies → Original source

  21. 2021-06-24

    The Air We Breathe: Air Pollution as a Prevalent Proinflammatory Stimulus Contributing to Neurodegeneration

    ✓ Peer-reviewed Risk factors Frontiers in cellular neuroscience

    Key finding: To date, accumulating reports have noted that particulate matter (PM) is closely associated with the course of cardiopulmonary disorders.

    Full summary, score breakdown and related studies → Original source

  22. 2021-06-24

    Using a Digital Neuro Signature to measure longitudinal individual-level change in Alzheimer's disease: the Altoida large cohort study

    ✓ Peer-reviewed Cognitive tests and assessment NPJ digital medicine

    Key finding: By comparison to conventional neuropsychological assessments, DNS results in faster evaluations (10 min vs 45-120 min), and generates higher test-retest in intraindividual assessment, as well as higher accuracy at detecting abnormal cognition. +2 more findings

    Full summary, score breakdown and related studies → Original source

  23. 2021-06-23

    Factors Associated With Hearing Aid Use Among Medicare Beneficiaries

    ✓ Peer-reviewed Risk factors Innovation in aging

    Key finding: Overall, 5,146 participants were included. +4 more findings

    Full summary, score breakdown and related studies → Original source

  24. 2021-06-23

    Alzheimer's and Aducanumab: Unjust Profits and False Hopes

    ⚠ Report — not peer-reviewed Health systems and care delivery The Hastings Center report

    Key finding: That approval was contrary to the nearly unanimous judgment of the FDA's Advisory Committee that little reliable evidence existed of significant benefit, even though the drug did reduce β-amyloid.

    Scored 25 on our rubric, shown as 16: non-peer-reviewed sources are capped at 16. See the breakdown.

    Full summary, score breakdown and related studies → Original source

  25. 2021-06-23

    Exploring hospital-based health information technology functions for patients with Alzheimer’s Disease and related Dementias

    ✓ Peer-reviewed Risk factors Preventive Medicine Reports

    Key finding: This study investigated whether hospital-adopted health information technology (HIT) is associated with a reduction in the frequency of preventable emergency department (ED) visits for patients with Alzheimer's Disease and Related Dementias (ADRD). +2 more findings

    Full summary, score breakdown and related studies → Original source

Browse the library by subject, with the full score breakdown →