Newest studies

Interactions Between Weight Loss and Plasma Neurodegenerative Markers for Determining Cognitive Decline Among Community-Dwelling Older Adults

54/100 ✓ Peer-reviewed Biomarkers The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: In adjusted analyses, combined WL + lower Aβ 42/40 (≤0.103, lowest quartile) was related with more pronounced 4-year cognitive decline according to CDR-SB (p < .0001) and MMSEO (p = .021), compared with non-WL + higher Aβ 42/40. +3 more findings

• Biomarkers

Full summary, score breakdown and related studies → Original source

Identification of Dementia in Recent Medicare Claims Data, Compared With Rigorous Clinical Assessments

50/100 ✓ Peer-reviewed Costs and economics The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: Recent Medicare claims perform reasonably well in identifying dementia; however, there are consistent differences in cases of dementia identified through claims than in rigorous cohort evaluations. +4 more findings

• Policy

Full summary, score breakdown and related studies → Original source

Validation of Claims Algorithms to Identify Alzheimer's Disease and Related Dementias

43/100 ✓ Peer-reviewed Costs and economics The journals of gerontology. Series A, Biological sciences and medical sciences

Key finding: Revised algorithms for dementia diagnosis using Medicare administrative data have reasonable accuracy for research purposes, but investigators should be cognizant of the tradeoffs in accuracy among the approaches they consider.

Full summary, score breakdown and related studies → Original source

Therapeutic Potential of Semaglutide, a Newer GLP-1 Receptor Agonist, in Abating Obesity, Non-Alcoholic Steatohepatitis and Neurodegenerative diseases: A Narrative Review

43/100 ✓ Peer-reviewed Drug development Pharmaceutical research

Key finding: Significant weight reduction ability of semaglutide has been demonstrated in various phase-3 clinical trials, for which recently semaglutide became the first long-acting GLP-1 receptor agonist to be approved by the United States Food and Drug Administration for management of obesity. +1 more finding

• Treatments
• Risk Factors

Full summary, score breakdown and related studies → Original source

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

40/100 ✓ Peer-reviewed Genetics Cell

Key finding: Further, matrisome dysregulation is associated with upregulated chemotaxis, glial activation, and lipid biosynthesis in astrocytes co-cultured with neurons, which recapitulates altered astrocyte matrisome signaling in human brain.

• Brain Biology
• Genetics
• Risk Factors

Full summary, score breakdown and related studies → Original source

Hospice Improves Care Quality For Older Adults With Dementia In Their Last Month Of Life

40/100 ✓ Peer-reviewed End-of-life care Health affairs (Project Hope)

Key finding: We asked whether and how the perceived quality of last-month-of-life care differed between people with and without dementia and whether hospice use among people living with dementia was associated with perceived quality of care compared with the quality of care for those who did not use hospice. +1 more finding

• End-of-Life Care
• Care Services
• Policy

Full summary, score breakdown and related studies → Original source

Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial

84/100 ✓ Peer-reviewed Prevention trials European heart journal

Key finding: A 2-year multi-domain lifestyle intervention among older adults was effective in preventing cerebrovascular events and also total CVD events among those who had history of CVD. +1 more finding

• Risk Factors
• Clinical Trials
• Lifestyle

Full summary, score breakdown and related studies → Original source

Imaging of Synaptic Density in Neurodegenerative Disorders

40/100 ✓ Peer-reviewed Disease mechanisms Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: Next, we review human PET imaging results in multiple neurodegenerative disorders. +3 more findings

• Brain Biology
• Brain Scans

Full summary, score breakdown and related studies → Original source

Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q

40/100 ✓ Peer-reviewed Disease mechanisms Science translational medicine

Key finding: Single-nuclei transcriptomics demonstrated that SAM treatment in both models normalized expression patterns to a far greater extent in neurons than glia.

• Brain Biology
• Treatments
• Prevention

Full summary, score breakdown and related studies → Original source

18F-FDG PET Imaging in Neurodegenerative Dementing Disorders: Insights into Subtype Classification, Emerging Disease Categories, and Mixed Dementia with Copathologies

40/100 ✓ Peer-reviewed Disease mechanisms Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: Each of these subtypes is associated with differential 18 F-FDG PET findings. +3 more findings

• Brain Scans
• Other Dementias

Full summary, score breakdown and related studies → Original source

Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study

60/100 ✓ Peer-reviewed Long-term cohort studies The lancet. Healthy longevity

Key finding: Individual cardiometabolic disorders and genetic factors are associated with an increased dementia risk; however, the relationship between dementia and cardiometabolic multimorbidity is unclear. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

The Medicolegal and Ethical Dimensions of Physician Prescription Reluctance

28/100 ✓ Peer-reviewed Drug development Continuum (Minneapolis, Minn.)

Key finding: This article addresses the potential legal ramifications for neurologists caring for patients with Alzheimer disease (AD) who elect neither to prescribe aducanumab nor to refer patients with AD for treatment with aducanumab. +3 more findings

• Treatments

Full summary, score breakdown and related studies → Original source

Biomarkers with Plasma Amyloid β and Tau Protein Assayed by Immunomagnetic Reduction in Patients with Amnestic Mild Cognitive Impairment and Alzheimer's Disease

34/100 ✓ Peer-reviewed Tau biomarkers Acta neurologica Taiwanica

Key finding: Recent studies have focused on the differential diagnosis of normal controls (NCs) with aMCI or AD. +3 more findings

• Biomarkers
• Brain Biology
• Early Stage

Full summary, score breakdown and related studies → Original source

Genetics of Alzheimer's disease: an East Asian perspective

50/100 ✓ Peer-reviewed TREM2 and immune genetics Journal of human genetics

Key finding: Advances in genome technology, including next generation sequencing have uncovered complex genetic effects in AD by analyzing both common and rare functional variants. +3 more findings

• Genetics

Full summary, score breakdown and related studies → Original source

Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice

53/100 ✓ Peer-reviewed TREM2 and immune genetics Cell reports

Key finding: Here we utilize a CSF1R hypomorphic mouse to generate a model of AD that genetically lacks microglia. +3 more findings

• Brain Biology

Full summary, score breakdown and related studies → Original source

A systematic literature review and meta-analysis on digital health interventions for people living with dementia and Mild Cognitive Impairment

63/100 ✓ Peer-reviewed Digital health tools International journal of geriatric psychiatry

Key finding: Supervised intervention delivery is linked to greatest benefits. +1 more finding

• Digital Tools
• Early Stage

Full summary, score breakdown and related studies → Original source

Neuropathological fingerprints of survival, atrophy and language in primary progressive aphasia

62/100 ✓ Peer-reviewed Digital health tools Brain : a journal of neurology

Key finding: Comparisons of ADNC in typical amnestic versus atypical aphasic dementia and of TDP in type A versus type C revealed fundamental biological and clinical differences, suggesting that members of each pair may constitute distinct clinicopathologic entities despite identical downstream proteinopathies.

Full summary, score breakdown and related studies → Original source

Addition of Vision Impairment to a Life-Course Model of Potentially Modifiable Dementia Risk Factors in the US

58/100 ✓ Peer-reviewed Disparities JAMA neurology

Key finding: The number of older adults with dementia in the US and globally is projected to increase as a result of population aging and growth. +4 more findings

• Risk Factors
• Prevention

Full summary, score breakdown and related studies → Original source

Racial and Ethnic Differences in Hospice Use and Hospitalizations at End-of-Life Among Medicare Beneficiaries With Dementia

69/100 ✓ Peer-reviewed Disparities JAMA network open

Key finding: The cohort sample included 5058 beneficiaries with dementia (mean [SD] age, 85.5 [8.0] years; 3038 women [60.1%]; 809 [16.0%] non-Hispanic Black, 357 [7.1%] Hispanic, and 3892 non-Hispanic White respondents [76.9%]). +3 more findings

• Health Equity
• End-of-Life Care
• Care Services

Full summary, score breakdown and related studies → Original source

Tau PET Imaging in Neurodegenerative Disorders

55/100 ✓ Peer-reviewed Brain scans and imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: Although an increased neocortical tau PET signal is rare in cognitively unimpaired individuals, even in amyloid-β-positive cases, such a signal holds important prognostic information because preliminary data suggest that an elevated tau PET signal predicts cognitive decline over time. +1 more finding

• Brain Scans

Full summary, score breakdown and related studies → Original source

Risk Factors Associated With Alzheimer Disease and Related Dementias by Sex and Race and Ethnicity in the US

79/100 ✓ Peer-reviewed Prevention and risk JAMA neurology

Key finding: The findings suggest that risk factors associated with ADRDs have changed over the past decade and differ based on sex and race and ethnicity. +4 more findings

• Risk Factors
• Health Equity

Full summary, score breakdown and related studies → Original source

Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial

71/100 ✓ Peer-reviewed Treatments JAMA neurology

Key finding: Among 16 enrolled participants, the mean (SD) age was 32.6 (4.4) years; 9 participants were women, and 7 were men. +4 more findings

• Clinical Trials
• Side Effects
• Prevention

Full summary, score breakdown and related studies → Original source

Associations Between Handgrip Strength and Dementia Risk, Cognition, and Neuroimaging Outcomes in the UK Biobank Cohort Study

61/100 ✓ Peer-reviewed Genetics JAMA network open

Key finding: To evaluate reverse causation, we assessed whether a polygenic risk score for AD is associated with HGS. +4 more findings

• Genetics
• Risk Factors
• Brain Scans

Full summary, score breakdown and related studies → Original source

Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease

63/100 ✓ Peer-reviewed Biomarkers JAMA neurology

Key finding: This study suggests that early tau deposition may follow multiple trajectories during preclinical AD and may involve several cortical regions. +2 more findings

• Brain Scans
• Early Stage

Full summary, score breakdown and related studies → Original source

The Role of Amyloid PET in Imaging Neurodegenerative Disorders: A Review

52/100 ✓ Peer-reviewed Biomarkers Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Key finding: Amyloid PET is a crucial tool for the diagnosis of Alzheimer disease, as it allows the noninvasive detection of amyloid plaques, a core neuropathologic feature that defines the disease. +4 more findings

• Brain Scans
• Treatments
• Brain Biology

Full summary, score breakdown and related studies → Original source